13 research outputs found

    Molecular insights into the premature aging disease progeria

    Get PDF

    Cirrus cloud retrieval with MSG/SEVIRI using artificial neural networks

    No full text
    Cirrus clouds play an important role in climate as they tend to warm the Earth–atmosphere system. Nevertheless their physical properties remain one of the largest sources of uncertainty in atmospheric research. To better understand the physical processes of cirrus clouds and their climate impact, enhanced satellite observations are necessary. In this paper we present a new algorithm, CiPS (Cirrus Properties from SEVIRI), that detects cirrus clouds and retrieves the corresponding cloud top height, ice optical thickness and ice water path using the SEVIRI imager aboard the geostationary Meteosat Second Generation satellites. CiPS utilises a set of artificial neural networks trained with SEVIRI thermal observations, CALIOP backscatter products, the ECMWF surface temperature and auxiliary data. CiPS detects 71 and 95 % of all cirrus clouds with an optical thickness of 0.1 and 1.0, respectively, that are retrieved by CALIOP. Among the cirrus-free pixels, CiPS classifies 96 % correctly. With respect to CALIOP, the cloud top height retrieved by CiPS has a mean absolute percentage error of 10 % or less for cirrus clouds with a top height greater than 8 km. For the ice optical thickness, CiPS has a mean absolute percentage error of 50 % or less for cirrus clouds with an optical thickness between 0.35 and 1.8 and of 100 % or less for cirrus clouds with an optical thickness down to 0.07 with respect to the optical thickness retrieved by CALIOP. The ice water path retrieved by CiPS shows a similar performance, with mean absolute percentage errors of 100 % or less for cirrus clouds with an ice water path down to 1.7 g m−2. Since the training reference data from CALIOP only include ice water path and optical thickness for comparably thin clouds, CiPS also retrieves an opacity flag, which tells us whether a retrieved cirrus is likely to be too thick for CiPS to accurately derive the ice water path and optical thickness. By retrieving CALIOP-like cirrus properties with the large spatial coverage and high temporal resolution of SEVIRI during both day and night, CiPS is a powerful tool for analysing the temporal evolution of cirrus clouds including their optical and physical properties. To demonstrate this, the life cycle of a thin cirrus cloud is analysed

    Expression of progerin in aging mouse brains reveals structural nuclear abnormalities without detectible significant alterations in gene expression, hippocampal stem cells or behavior

    Get PDF
    Hutchinson–Gilford progeria syndrome (HGPS) is a segmental progeroid syndrome with multiple features suggestive of premature accelerated aging. Accumulation of progerin is thought to underlie the pathophysiology of HGPS. However, despite ubiquitous expression of lamin A in all differentiated cells, the HGPS mutation results in organ-specific defects. For example, bone and skin are strongly affected by HGPS, while the brain appears to be unaffected. There are no definite explanations as to the variable sensitivity to progeria disease among different organs. In addition, low levels of progerin have also been found in several tissues from normal individuals, but it is not clear if low levels of progerin contribute to the aging of the brain. In an attempt to clarify the origin of this phenomenon, we have developed an inducible transgenic mouse model with expression of the most common HGPS mutation in brain, skin, bone and heart to investigate how the mutation affects these organs. Ultrastructural analysis of neuronal nuclei after 70 weeks of expression of the LMNA c.1824C>T mutation showed severe distortion with multiple lobulations and irregular extensions. Despite severe distortions in the nuclei of hippocampal neurons of HGPS animals, there were only negligible changes in gene expression after 63 weeks of transgenic expression. Behavioral analysis and neurogenesis assays, following long-term expression of the HGPS mutation, did not reveal significant pathology. Our results suggest that certain tissues are protected from functional deleterious effects of progerin

    PECyT - Plasma Enhanced Cycloidal Thruster

    No full text
    In the following paper we introduce PECyT system for enhancing the aerodynamic efficiency of cycloidal rotors. For that purpose the incorporation of Dielectric Barrier Discharge plasma actuators for active flow control on a pitching airfoil, under deep-stall conditions, will be assessed using a numerical tool. Two different arrangements of DBD actuators will be analysed, namely single- and multi-DBDs configurations. For the single- DBD plasma actuator the effect of different modes of actuation on the lift coefficient will also be studied. We will show that the multi-DBD actuator, in a steady-actuation mode, could delay stall and allows for a faster reattachment of the flow. However during the downstroke phase of the pitching cycle the unsteady operation of a single-DBD gives us the best results in terms of lift coefficient

    The added value of large-eddy and storm-resolving models for simulating clouds and precipitation

    No full text
    This study investigates, if atmospheric models with horizontal resolutions of 100 m to 2 km are able to better simulate key features, like clouds and precipitation, of the climate system than currently used models employing much coarser resolution and parameterized convection. Precipitation characteristics are much more realistic in the simulations with explicitly convection, already at kilometer resolutions. Increasing resolution to hectometer scales improves the simulation of precipitation only modestly, but substantially improves the simulation of clouds. The results suggest that new climate models, which explicitly resolve convection and the interaction with its environment, offer exciting opportunities to learn about the climate system
    corecore