25 research outputs found
Facile Approach to Covalent Copolypeptide Hydrogels and Hybrid Organohydrogels
Crosslinking
of tryptophan (Trp) containing copolypeptides with
varying ratios of benzyl-l-glutamate (BLG) and Nα-(carbobenzyloxy)-l-lysine (Z-Lys) is achieved by the selective reaction with
hexamethylene-bis-TAD (bisTAD). Conversion of the resulting organogels
into biocompatible hydrogels by full BLG or Z-Lys deprotection is
demonstrated. Moreover, diffusion controlled deprotection allows the
design of macroscopic hybrid organohydrogels comprising hydrophilic
as well as hydrophobic regions at a desired ratio and position. FTIR
and SEM analysis confirm the coexistence of both hydrophilic and hydrophobic
segments in one copolypeptide piece. Selective loading of hydrogel
and organogel segments with hydrophilic and hydrophobic dyes, respectively,
is observed on macroscopic amphiphilic gels and films. These materials
offer significant potential as dual-loaded drug release gels as well
as tissue engineering platforms
Facile Approach to Covalent Copolypeptide Hydrogels and Hybrid Organohydrogels
Crosslinking
of tryptophan (Trp) containing copolypeptides with
varying ratios of benzyl-l-glutamate (BLG) and Nα-(carbobenzyloxy)-l-lysine (Z-Lys) is achieved by the selective reaction with
hexamethylene-bis-TAD (bisTAD). Conversion of the resulting organogels
into biocompatible hydrogels by full BLG or Z-Lys deprotection is
demonstrated. Moreover, diffusion controlled deprotection allows the
design of macroscopic hybrid organohydrogels comprising hydrophilic
as well as hydrophobic regions at a desired ratio and position. FTIR
and SEM analysis confirm the coexistence of both hydrophilic and hydrophobic
segments in one copolypeptide piece. Selective loading of hydrogel
and organogel segments with hydrophilic and hydrophobic dyes, respectively,
is observed on macroscopic amphiphilic gels and films. These materials
offer significant potential as dual-loaded drug release gels as well
as tissue engineering platforms