Lymph nodes go with the flow

In this issue, Bovay et al. (https://doi.org/10.1084/jem.20180217) invoke a compelling model of interplay between the venous and lymphatic vasculature in regulating the developmental genesis and early expansion of LNs. This work supports an emerging model that lymph-venous crosstalk supports LN functionality at all stages

STARPROBE: Scientific rationale

The scientific rationale and instrumentation problems in the areas of solar internal dynamics and relativity, solar plasma and particle dynamics, and solar atmosphere structure were studied. Current STARPROBE mission and system design concepts are summarized

Computational Fluid Dynamics Applied to Transport Systems in Trees

Our ecosystem is dependent upon the ability of photosynthetic plants to convert solar energy into a form of energy useable to biological organisms. Even so, much remains to become understood about how plants function. With such expansive bodies,how do trees cyclewaterand nutrients throughouttheir bodies

Pyrotechnic shock analysis and testing methods

Pyrotechnic shock analysis and testing methods for Ranger and Mariner spacecraft measurement

Experimental studies of perceptual processes, section two Progress report, Jan. - Sep. 30, 1965

Complex discriminative behavior, fixed ratio reinforcement of large units of behavior and deferred reinforcement studied in chimpanzee

Restoring Functional Status: A Long-Term Case Report of Severe Lung and Ventilatory Muscle Pump Dysfunction Involving Recurrent Bacterial Pneumonias

Background and Purpose: Prolonged mechanical ventilation contributes to immobility and deconditioning making efforts to safely discontinue ventilator support desirable. This case report documents how implementing physical therapy treatment interventions, based on the Guide to Physical Therapist Practice, can help to restore a person’s functional status even after multiple years of mechanical ventilation dependency. Case Description: A patient (female; aged 63 years) with severe restrictive and obstructive ventilatory impairment has survived 34 recurrent pneumonias involving 6 bacterial pathogens while being mechanically ventilated at home. A 3-year study was approved and informed consent obtained for a home exercise program of resistive extremity and inspiratory muscle training along with exercise reconditioning. Tolerable distances walked, maximal inspiratory and expiratory pressures, hours spent on versus off mechanical ventilation, activities performed within and around her home, and community excursions taken were charted. Outcomes: Daily time tolerated off the ventilator improved from less than one to 12 hours, distance walked in 6 minutes increased 33%, and maximal inspiratory and expiratory pressures improved 62% and 9.6% respectively. These improvements made out-of-home social excursions possible. Discussion and Conclusions: This patient’s functional status improved following multiple physical therapy interventions dictated by the evaluation of initial physical therapy examination findings according to the Guide to Physical Therapist Practice. Long term mechanical ventilator dependency in the home environment did not exclude this patient from achieving clinically significant gains in functional status even when having severe restrictive and obstructive ventilator impairment

Stability radius and internal versus external stability in Banach spaces: an evolution semigroup approach

In this paper the theory of evolution semigroups is developed and used to provide a framework to study the stability of general linear control systems. These include time-varying systems modeled with unbounded state-space operators acting on Banach spaces. This approach allows one to apply the classical theory of strongly continuous semigroups to time-varying systems. In particular, the complex stability radius may be expressed explicitly in terms of the generator of a (evolution) semigroup. Examples are given to show that classical formulas for the stability radius of an autonomous Hilbert-space system fail in more general settings. Upper and lower bounds on the stability radius are provided for these general systems. In addition, it is shown that the theory of evolution semigroups allows for a straightforward operator-theoretic analysis of internal stability as determined by classical frequency-domain and input-output operators, even for nonautonomous Banach-space systemsComment: Also at http://www.math.missouri.edu/~stephen/preprint