Independent Study: Understanding the Pharmaceutical Industry

An undergraduate Healthcare Sales student wanted to understand the pharmaceutical (pharma) industry better to determine if the industry was a good fit. She approached her professor to gain support for an independent study to understand better the history and challenges of selling in the pharma industry. Once completed, the pair recognized this information\u27s value and collaborated in editing the document to share these findings to provide this entry-level salesperson\u27s guide to understanding the pharma industry. Six semi-structured interviews of pharma professionals showed three primary areas of knowledge and ethics required of the entry-level pharma industry salesperson. These suggestions are for the salesperson to 1) focus on patient safety, 2) establish trust-based relationships, and 3) comply with industry guidelines. The study concludes with an overview of three prominent industry guidelines: the PhRMA Code, the Sunshine Act, and the Fair Balance practices

Alien Registration- Nelsen, Charles J. (Portland, Cumberland County)

https://digitalmaine.com/alien_docs/31190/thumbnail.jp

In Defense of Playfulness

Nelsen argues that the loss of play has unwittingly provoked a loss of critical thinking and civic engagement

Katie’s Closet: An On-campus Experiential Learning Project

Two faculty and one undergraduate student embarked on an applied learning experience to determine the feasibility of starting a free professional clothing shop for University students called Katie\u27s Closet. All aspects of conceptualizing and testing the Katie\u27s Closet pop-up-store concept began from a feasibility study. With the support of faculty mentors, the undergraduate student researched, analyzed, and executed the project. The action research project started with informational interviews and a focus group for gathering qualitative data on the student population\u27s needs. These findings led to more research to explore potential collaborative partnerships with other University departments. Competitive benchmarking also supported developing the entrepreneurial project concept and offered insightful information to help with the start-up. The data provided the foundational knowledge to create and market a Katie\u27s Closet pop-up store on campus. This article is a collaborative effort written by both the undergraduate student intern and her faculty mentors

Asymptotic Conditional Distribution of Exceedance Counts: Fragility Index with Different Margins

Let $\bm X=(X_1,...,X_d)$ be a random vector, whose components are not necessarily independent nor are they required to have identical distribution functions $F_1,...,F_d$. Denote by $N_s$ the number of exceedances among $X_1,...,X_d$ above a high threshold $s$. The fragility index, defined by $FI=\lim_{s\nearrow}E(N_s\mid N_s>0)$ if this limit exists, measures the asymptotic stability of the stochastic system $\bm X$ as the threshold increases. The system is called stable if $FI=1$ and fragile otherwise. In this paper we show that the asymptotic conditional distribution of exceedance counts (ACDEC) $p_k=\lim_{s\nearrow}P(N_s=k\mid N_s>0)$, $1\le k\le d$, exists, if the copula of $\bm X$ is in the domain of attraction of a multivariate extreme value distribution, and if $\lim_{s\nearrow}(1-F_i(s))/(1-F_\kappa(s))=\gamma_i\in[0,\infty)$ exists for $1\le i\le d$ and some $\kappa\in{1,...,d}$. This enables the computation of the FI corresponding to $\bm X$ and of the extended FI as well as of the asymptotic distribution of the exceedance cluster length also in that case, where the components of $\bm X$ are not identically distributed

Letter from the Editors

An introduction from the editors to volume 19, issue 2 of Democracy & Education

Cell Attachment and Mouse Virulence of Echovirus 9 Correlate with an RGD Motif in the Capsid Protein VP1

AbstractThe recently analyzed sequences of the nonpathogenic prototype strain Hill and the mouse-virulent strain Barty of the human echovirus 9 differ particularly in an insertion coding for an RGD motif at the C-terminus of the capsid protein VP1 in the genome of strain Barty. To investigate molecular determinants of virulence, we generated a panel of recombinant viruses derived from cDNA clones of strains Hill and Barty. In this communication, we show that the mouse-pathogenic character of strain Barty correlates with a 310-aa segment including the RGD motif. By mutating the RGD to an RGE tripetide, the infectivity of the resulting echovirus 9 clones for GMK cells is lost. Furthermore, we could show that synthetic peptides containing the RGD sequence influence binding of mouse-virulent echovirus 9 strains to GMK cells, whereas binding of apathogenic strains is not affected. These results suggest that the RGD motif is a significant factor affecting pathogenicity of echovirus 9 strains

Statistical Communication Theory

Contains reports on work completed and one research projects.Joint Services Electronics Programs (U. S. Army, U.S. Navy, and U.S. Air Force) under Contract DA 28-043-AMC-02536(E)National Aeronautics and Space Administration (Grant NsG-496

Statistical Communication Theory

Contains reports on two research projects.National Science Foundation (Grant GP-2495)National Institutes of Health (Grant MH-04737-04),National Aeronautics and Space Administration (Grant NsG-496