An experiment to detect gut monopoles

Recent advances in the development of Grand Unification Theories have led to several interesting predictions. One of these states that Grand Unification Monopoles (GUMs) exist as solutions in may nonabelian gauge theories. Another consequence of Unification is the possibility of baryon decay. The efficiency of the water tank detector in registering a Rubakov type decay will vary with both the interaction length and the GUM's velocity, expressed in terms of beta ( 0.01). The efficiency decreases at large values of because of the limited resolving time of the detector (approx. 50 ns). At lower values of Beta the time between interactions is such that the criterion of 4 events in 2 mu s can no longer be satisfied. The Rubakov experiment has now been in operation for almost 2 years with an estimated live time of 80%. During this time no candidate events have been observed leading to an estimated upper limit on the flux of 7.82 x 0.00001 m(-2) d(-1) Sr(-1). The ionization loss detection system has only recently come on line and as yet no results are available from this experiment

Recruiting ethnic minority participants to a clinical trial: a qualitative study

This is an open-access article distributed under the terms of the Creative Commons Attribution Non-commercial License, which permits use, distribution, and reproduction in any medium, provided the original work is properly cited, the use is non-commercial and is otherwise in compliance with the license.To compare the motives and experiences of different ethnic groups participating in a randomised double blind placebo-controlled trial of montelukast in preschool wheeze, and to assess parents' or guardians' understanding of trial procedures and their implications, including the collection of genetic material.National Institute of Health Research Efficacy and Mechanism Evaluation Stream(grant number: 08-43-03)

Emollient satisfaction questionnaire:validation study in children with eczema

BACKGROUND: Emollients are used as maintenance therapy for all severities of eczema but there is a lack of head‐to‐head comparisons of effectiveness and acceptability. AIM: To determine the validity of a self‐report questionnaire designed to assess user satisfaction with a given emollient and to report the findings. METHODS: Data were analysed from the Choice of Moisturiser for Eczema Treatment trial, which compared four emollient types (Aveeno(®) lotion, Diprobase(®) cream, Doublebase(®) gel and Hydromol(®) ointment) in children aged < 5 years with clinically diagnosed eczema. An emollient satisfaction questionnaire was completed after 12 weeks. Responses for individual items were scored from 0 to 4. Total scores ranged from 0 to 28 (low to high satisfaction). Completion rates and distributions of responses for individual items and total scores, categorized by emollient type, were assessed, and two hypotheses were tested to determine the questionnaire's construct validity. RESULTS: Data from 77.2% (152 of 197) of participants were analysed. One item was rejected because of a high rate (44.7%) of ‘don't know’ responses, leaving seven items with high completion rates (98.7%) and weak evidence of floor or ceiling effects. A positive association was observed between total score and overall emollient satisfaction (Spearman correlation 0.78; P < 0.001). Total scores were highest (mean ± SD 23.5 ± 3.9) in the lotion group and lowest (18.4 ± 4.6) in the ointment group. CONCLUSION: The emollient satisfaction questionnaire appears to have good validity. Further work is required to validate the questionnaire in other settings and to assess its reliability