Rationale for tau aggregation inhibitor therapy in Alzheimer's disease and other tauopathies

Preprin

Electron paramagnetic resonance studies of slowly tumbling vanadyl spin probes in nematic liquid crystals

An analysis of EPR line shapes by the method of Polnaszek, Bruno, and Freed is made for slowly tumbling vanadyl spin probes in viscous nematic liquid crystals. The use of typical vanadyl complexes as spin probes for nematic liquid crystals is shown to simplify the theoretical analysis and the subsequent interpretation. Rotational correlation times tau and orientational ordering parameters S sub Z where slow tumbling effects are expected to be observed in vanadyl EPR spectra are indicated in a plot. Analysis of the inertial effects on the probe reorientation, which are induced by slowly fluctuating torque components of the local solvent structure, yield quantitative values for tau and S sub Z. The weakly ordered probe VOAA is in the slow tumbling region and displays these inertial effects throughout the nematic range of BEPC and Phase V. VOAA exhibits different reorientation behavior near the isotropic-nematic transition temperature than that displayed far below this transition temperature

The study of comets, part 1

Papers are presented dealing with observations of comets. Topic discussed include: photometry, polarimetry, and astrometry of comets; detection of water and molecular transitions in comets; ion motions in comet tails; determination of comet brightness and luminosity; and evolution of cometary orbits. Emphasis is placed on analysis of observations of comet Kohoutek

The reduction of magnetite and lean magnetite sinters.

The problems encountered in at tempt.ing to determine the rate controlling step in the reduction of magnetite end sinters to iron are revealed by a survey of the pertinent literature. On the basis of previous work supplemented by the investigations reported in this thesis the probable sequence of rate controlling steps has been determined. Exhaustive metallographic and mathematical studies have been carried out on the hydrogen reduction of magnetite and lean magnetite sinter samples reduced in thermal balances.The existence of rate minima at 650°C and 900°C in the reduction of magnetite has been shown by metallographic techniques. Additionally the extent of chemical reaction and mass transport control has been shown by mathematical studies. Similarly the extent of chemical and transport control in sinter reduction has been shown metallographically and mathematically. The effect of thermal treatment in oxidising and inert atmosphere has been shown. The improvement in reaction rates as a result of particular thermal treatments has been displayed