Melodic Voicing: How to Have a Professional Sounding Melody in Seven Weeks

This presentation will show the first chapter of a method that will help piano teachers teach melodic voicing to a wide range of piano students. This is the first time that these concepts have been packaged as a method

Developing a mobile audiometric sound booth application for Apple IOS devices

Hearing loss in Australian children, particularly those in rural and remote areas, is a growing health concern. Resultant deafness has significant impact on the educational and social development of such children. Whilst telehealth had provided other benefits for rural and remote areas, the absence of suitable testing equipment and associated healthcare specialists has meant that there is a gap in this area of child health that could be addressed using a mobile solution. This paper discusses the research and development of a mobile application for testing and diagnosis of hearing loss in children. It is unique in its ability to be able to function in uncontrolled test environments, and conforms to current hearing assessment standards. The application also produces an audiogram that can be immediately electronically transferred to the relevant healthcare provider. The application is specifically designed for young children to use and is designed to be used in collaboration with healthcare specialist audiologists and paediatricians. The prototype is currently undergoing testing at the Telethon Speech and Hearing institute, Perth, Western Australia. The results are expected to deliver crucial quantitative data to determine the accuracy of the application, as well as qualitative data from healthcare professionals and consumers

Purinergic receptor mediated calcium signalling in urothelial cells

Non-neuronal ATP released from the urothelium in response to bladder stretch is a key modulator of bladder mechanosensation. Whilst non-neuronal ATP acts on the underlying bladder afferent nerves to facilitate sensation, there is also the potential for ATP to act in an autocrine manner, modulating urothelial cell function. The aim of this study was to systematically characterise the functional response of primary mouse urothelial cells (PMUCs) to ATP. PMUCs isolated from male mice (14-16 weeks) were used for live-cell fluorescent calcium imaging and qRT-PCR to determine the expression profile of P2X and P2Y receptors. The majority of PMUCs (74-92%) responded to ATP (1 μM-1 mM), as indicted by an increase in intracellular calcium (iCa2+). PMUCs exhibited dose-dependent responses to ATP (10 nM-1 mM) in both calcium containing (2 mM, EC50 = 3.49 ± 0.77 μM) or calcium free (0 mM, EC50 = 9.5 ± 1.5 μM) buffers. However, maximum iCa2+ responses to ATP were significantly attenuated upon repetitive applications in calcium containing but not in calcium free buffer. qRT-PCR revealed expression of P2X1-6, and P2Y1-2, P2Y4, P2Y6, P2Y11-14, but not P2X7 in PMUCs. These findings suggest the major component of ATP induced increases in iCa2+ are mediated via the liberation of calcium from intracellular stores, implicating functional P2Y receptors that are ubiquitously expressed on PMUCs.Russell Chess-Williams, Donna J. Sellers, Stuart M. Brierley, David Grundy, Luke Grund

Developing a Mobile Audiometric Sound Booth Application for Apple IOS Devices

Hearing loss in Australian children, particularly those in rural and remote areas, is a growing health concern. Resultant deafness has significant impact on the educational and social development of such children. Whilst telehealth had provided other benefits for rural and remote areas, the absence of suitable testing equipment and associated healthcare specialists has meant that there is a gap in this area of child health that could be addressed using a mobile solution. This paper discusses the research and development of a mobile application for testing and diagnosis of hearing loss in children. It is unique in its ability to be able to function in uncontrolled test environments, and conforms to current hearing assessment standards. The application also produces an audiogram that can be immediately electronically transferred to the relevant healthcare provider. The application is specifically designed for young children to use and is designed to be used in collaboration with healthcare specialist audiologists and paediatricians. The prototype is currently undergoing testing at the Telethon Speech and Hearing institute, Perth, Western Australia. The results are expected to deliver crucial quantitative data to determine the accuracy of the application, as well as qualitative data from healthcare professionals and consumers