Fluids and barriers of the CNS: a historical viewpoint

Tracing the exact origins of modern science can be a difficult but rewarding pursuit. It is possible for the astute reader to follow the background of any subject through the many important surviving texts from the classical and ancient world. While empirical investigations have been described by many since the time of Aristotle and scientific methods have been employed since the Middle Ages, the beginnings of modern science are generally accepted to have originated during the 'scientific revolution' of the 16th and 17th centuries in Europe. The scientific method is so fundamental to modern science that some philosophers consider earlier investigations as 'pre-science'. Notwithstanding this, the insight that can be gained from the study of the beginnings of a subject can prove important in the understanding of work more recently completed. As this journal undergoes an expansion in focus and nomenclature from cerebrospinal fluid (CSF) into all barriers of the central nervous system (CNS), this review traces the history of both the blood-CSF and blood-brain barriers from as early as it was possible to find references, to the time when modern concepts were established at the beginning of the 20th century

Epilepsy in the Graeco-Roman world: Hippocratic medicine and Asklepian temple medicine compared

The rational system of medicine distinct from magical or religious practices originated with Hippocrates. This revolutionary change established diseases with natural causes and treatments. Epilepsy with its prominent physical and psychic features was regarded in ancient times with superstitious awe and given the name "Sacred Disease." Hippocratic authors distanced themselves from the prevailing supernatural views but were careful not to oppose the traditional medicine especially the cults of Asklepios. This analysis of the practices of Hippocratic and Temple medicine in relation to epilepsy reveals some clear differences and also some overlapping features