Neomicin - čest kontaktni alergen

The incidence of allergic contact dermatitis from neomycin evaluated in relation to 1381 verified cases of allergic contact dermatitis showed a progressive increase (5.00,7.69,10.18%) over a three-year period (1990-1992). Sensitivity to neomycin was investigated with special reference to possible cross-reactions between neomycin and the allergens that are commonly used in the manufacture of cosmetic products. Contact sensitivity to neomycin was found to be present with the other diagnoses, such as atopic dermatitis, seborrhoeic dermatitis, hypostasic dermatitis and psoriasis vulgaris.Pratili smo učestalost kontaktnog alergijskog dermatitisa na neomicin u razdoblju od 1990. do 1992. godine (5,00%; 7,69%, 10,18%) s obzirom na 1381 verificiran kontaktni alergijski dermatitis. Istodobno je prikazan kontaktni alergijski dermatitis s pozitivitetom na neomicin u odnosu na alergene s kojima može imati unakrsne reakcije, a rabe se često u kozmetičkim pripravcima. Prikazali smo kontaktnu senzibilizaciju na neomicin i u drugih dermatoza u kojih se češće javlja: neurodermatitis, seboroički dermatitis, hipostazički dermatitis i vulgarna psorijaza

Are Respiratory Allergic Diseases Related to Atopic Dermatitis?

The difference of test results between patients with »pure« atopic dermatitis (AD) and »mixed« AD (with concomitant respiratory allergy, RA) was investigated in 30 AD patients. The results showed the onset of disease that mostly occur in the early infancy _15 (50%) patients had developed the disease under the age of 2 – 2/10 in »pure« AD, and 13/20 in »mixed« AD_. Twenty (66.6%) of them had a history of RA (»mixed« AD) whereas the remaining 10 (33.3%) had »pure« AD. Seventeen (56.6%) AD patients had one concomitant allergic disease, while 3 (10%) patients had two comorhid conditions (AR and AB) each. Family history was positive for atopy in 22 (73.3%) AD patients _in 14 (46.6%) patients in a first-degree relative_. Twenty-four (80%) patients had positive prick test 9/10 (90%) in »pure« AD and 15/20 (75%) in »mixed« AD, mostly for house dust (20). Positive scratch test was observed in 16 (53.3%) patients _4/10 in »pure« AD, and 12/20 in »mixed« AD_. Nineteen (63.3%) AD patients showed positive patch test reaction 5/10 in »pure« AD, and 14/20 in »mixed« AD. AD patients had higher serum IgE (21/30) than non-atopic ones but similar in »pure« AD, and »mixed« AD _7/10 (70%) in »pure« AD, and 14/20 (70%) in »mixed« AD_. Determination of CD23 marker on B-lymphocytes showed normal values in 24, and increased values in six patients 2/10 in »pure« AD, and 4/20 in »mixed« AD. The values of CD21 were decreased in 16 AD patients 6/10 in »pure« AD, and 10/20 in »mixed« AD. HLA-DR expression was normal in almost all patients. There were no statistically significant differences (p<0.05) between the »pure« AD and »mixed« AD patient groups, except for the age at onset, which was younger in the group of patients with concomitant RA. Accordingly, study results pointed to the association between AD and RA

Kontaktna alergija i psorijaza

The study was conducted over a two-year period and included 48 psoriatic patients with palmar and plantar lesions and 61 psoriatic patients without palmar and plantar lesions who served as controls. The objective was to establish the incidence of contact sensitization and its importance as the causative factor in palmar and plantar psoriasis. The most frequent contact allergens were: nickel sulphate, mercapto mix, balsam of Peru, potassium dichromate, mercury mix and fragrance mix. Patch tests were positive in 41.7% psoriatics with palrnar-plantar psoriasis and in only 6.6% of psoriatics without palmar-plantar involvement. The study showed an increased incidence of contact allergy in patients with palmar-planter psoriasis.Istraživanje je provedeno tijekom dvije godine u skupini od 48 pacijenata s palmoplantarnim oblikom psorijaze i u kontrolnoj skupini od 61 pacijenta s psorijazom ali bez oštećenja na dlanovima ili stopalima. Cilj je bio utvrditi učestalost kontaktne senziibilizacije i njeno značenje kao uzročnog faktora u nastanku palmoplanlarne psorijaze. Najčešći kontaktni alergeni bili su nikalj sulfat, smjesa merkapto spojeva, peruvijanski balzam, kalijev bikromat, smjesa živinih spojeva i smjesa mirisa. Epikutani testovi bili su pozitivni u 41,7 % pacijenata s palmoplanlarnom psorijazom i samo u 6,6 % kontrolnih pacijenata. Istraživanje je pokazalo povećanu učestalost kontaktne alergije u pacijenata s palmoplantarnim oblikom psorijaze

A Case of Lichen Ruber Planus in a Patient with Familial Multiple Sclerosis

Multiple sclerosis and lichen ruber planus are clinically and histologically distinct complex disorders of putative autoimmune aetiology that are fairly commonly observed in isolation but rarely found in combination. Only two previous reports have described lichen skin disorders in association with multiple sclerosis. The present report describes the case of a 51-year old Caucasian woman exhibiting both familial multiple sclerosis and lichen ruber planus. This combination may have occurred by chance or it might imply that these disorders share common mechanisms in their pathogenesis