Language effects in trilinguals: An ERP study.

International audienceEvent-related potentials were recorded during the visual presentation of words in the three languages of French-English-Spanish trilinguals. Participants monitored a mixed list of unrelated non-cognate words in the three languages while performing a semantic categorization task.Words in L1 generated earlier N400 peak amplitudes than both L2 and L3 words, which peaked together. On the other hand, L2 and L3 words did differ significantly in terms of N400 amplitude, with L3 words generating greater mean amplitudes compared with L2 words. We interpret the effects of peak N400 latency as reflecting the special status of the L1 relative to later acquired languages, rather than proficiency in that language per se. On the other hand, the mean amplitude difference between L2 and L3 is thought to reflect different levels of fluency in these two languages

The Neurotensin Receptor-1 Pathway Contributes to Human Ductal Breast Cancer Progression

BACKGROUND: The neurotensin (NTS) and its specific high affinity G protein coupled receptor, the NT1 receptor (NTSR1), are considered to be a good candidate for one of the factors implicated in neoplastic progression. In breast cancer cells, functionally expressed NT1 receptor coordinates a series of transforming functions including cellular migration and invasion. METHODS AND RESULTS: we investigated the expression of NTS and NTSR1 in normal human breast tissue and in invasive ductal breast carcinomas (IDCs) by immunohistochemistry and RT-PCR. NTS is expressed and up-regulated by estrogen in normal epithelial breast cells. NTS is also found expressed in the ductal and invasive components of IDCs. The high expression of NTSR1 is associated with the SBR grade, the size of the tumor, and the number of metastatic lymph nodes. Furthermore, the NTSR1 high expression is an independent factor of prognosis associated with the death of patients. CONCLUSION: these data support the activation of neurotensinergic deleterious pathways in breast cancer progression

El fin del imperio alemán : pronosticado por varias profecías célebres, precisas y concordantes : profecías de Hermann (monje de la Orden del Císter), profecías de Maguncia (del arvchivo del Monasterio de Santa Hildegarda), profecías de Fiensberg

Precede ao tít.: "Cómo llega en los actuales momentos"Data tomada da p.5: 191

Effets de la fréquence du voisinage orthographique interlangue lors de la reconnaissance visuelle de mots chez les bilingues

Summary : Interlingual neighborhood frequency effects in bilingual visual word recognition Interlingual orthographic neighborhood frequency was manipulated in a monolingual lexical decision task and a language decision task. The material was composed of words that are specific to a language (French or Spanish) and words of a target language that have an orthographic neighbor that is more frequent in the other language. Concerning the lexical decision task, bilinguals process interlingual neighbors more slowly than specific words, for the French lists (dominant language) as well as for the Spanish lists (non-dominant language). For both languages, similar interferences were observed for interlingual orthographic neighbors in the language decision task. These results are discussed with reference to the bilingual interactive activation model (BIA) that proposes the existence of a non-selective initial access to two integrated lexicons. Key words : bilingualism, visual word recognition, interlingual orthographic neighbors, specific words.Résumé Nous avons manipulé la fréquence du voisinage orthographique interlangue dans une tâche de décision lexicale monolingue et de décision de langue. Dans la décision lexicale, les bilingues français/espagnol traitent plus lentement des mots qui possèdent un voisin orthographique plus fréquent dans l'autre langue (voisins orthographiques interlangues) que des mots spécifiques à une seule langue, à la fois dans les listes françaises et espagnoles. Pour les deux langues, nous obtenons des ralentissements similaires pour les voisins orthographiques interlangues dans la tâche de décision de langue. Les résultats sont interprétés dans le cadre du modèle d'Activation Interactive Bilingue (BIA). Mots clés : bilinguisme, reconnaissance visuelle de mots, voisins orthographiques interlangues, mots spécifiques.Font Noëlle, Lavaur J.-M. Effets de la fréquence du voisinage orthographique interlangue lors de la reconnaissance visuelle de mots chez les bilingues. In: L'année psychologique. 2004 vol. 104, n°3. pp. 377-405

Etude de la distribution et de la persistance post mortem du carbofuran chez la caille japonaise (Coturnix japonica)

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Surveillance de la pollution en milieu dulcaquicole etude de la contamination des oeufs d'oiseaux aquatiques dans les etangs de la Brenne

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Glutamate induces histone H3 phosphorylation but not acetylation in striatal neurons: role of mitogen- and stress-activated kinase-1.

Chromatin remodelling is thought to play a key role in gene regulation that underlies long-term synaptic plasticity and memory formation. The dynamic process of chromatin remodelling requires post-translational modifications of histones, a group of highly basic proteins that are tightly linked to DNA. In the present study, we investigated histone H3 modifications in response to glutamate stimulation leading to c-Fos and c-Jun induction in an in vitro model system of striatal neurons in culture. Intracellular signalling pathways implicated in these modifications were analysed. Histone H3 acetylation was strong in basal conditions and unmodified by glutamate treatment. By contrast, glutamate induced a strong phosphorylation of histone H3 that was inhibited by selective inhibitors of the extracellular signal-regulated kinase (ERK) and p38 mitogen-activated protein kinase (p38 MAPK) pathways, U0126 and SB203580, respectively. Blocking activation of mitogen- and stress-activated kinase 1 (MSK1), a kinase downstream ERK and p38 MAPK, by pharmacological approach or using striatal cells from MSK1 deficient mice, totally abolished H3 phosphorylation, as well as c-Fos and c-Jun induction. Chromatin immunoprecipitation assays confirmed increased levels of phosphorylated H3 at the c-jun promoter. Altogether, our data highlight the crucial role of MSK1 in the nucleosomal response necessary for gene induction in neuronal cells

Recognising words in three languages: effects of language dominance and language switching

International audienc

A TAT DEF Elk-1 Peptide Regulates the Cytonuclear Trafficking of Elk-1 and Controls Cytoskeleton Dynamics

International audienc

Etude de la toxicite de l'Ioxynil et de sa localisation tissulaire chez le Lapin

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