Spatial market equilibrium for resistive electric networks

Thesis (M.S.)--Massachusetts Institute of Technology, Sloan School of Management, 1995.Includes bibliographical references (p. 50).by Barry J. Kostiner.M.S

Workers in the vanguard: the 1960 Industrial Relations Ordinance and the struggle for independence in Aden

The promulgation in 1960 of a new Industrial Relations Ordinance in Aden was a singular event in the history of British decolonisation because it made many forms of strike action illegal. Earlier initiatives to liberalise trade union law in the colonies were intended to channel and manage the discontent of workers; but for nationalist movements, the new order in industrial relations provided an opportunity to mobilise workers in the cause of independence. Aden, which was the location of a significant British base, a major oil refinery and a key commercial port, became the site of a bitter confrontation between the nascent trade union movement and the colonial administration. Three aspects of the conflict were of particular significance. First, Aden’s unique political status as a British colony in the Arab world and it strategic and economic value, contributed to the fractious industrial relations environment. Secondly, conflicts between workers and the colonial government demonstrate continuity with wider British efforts to suppress anti-colonial dissent and demonstrate that charges of appeasement in the last years of empire are not well founded. Lastly, the exceptional nature of the new legislation attracted the critical attention of the ILO and the major international trade union confederations, which internationalised the dispute over the IRO. An examination of the manner in which the British government sought to regulate its relations with various labour organisations, including the British TUC, the colonial ATUC and the two rival international labour confederations of the WFTU and ICFTU, demonstrates that the conduct of industrial relations in Aden was significant in the context of both the Cold War and decolonisation

Patients' ratings of genetic conditions validate a taxonomy to simplify decisions about preconception carrier screening via genome sequencing

Advances in genome sequencing and gene discovery have created opportunities to efficiently assess more genetic conditions than ever before. Given the large number of conditions that can be screened, the implementation of expanded carrier screening using genome sequencing will require practical methods of simplifying decisions about the conditions for which patients want to be screened. One method to simplify decision making is to generate a taxonomy based on expert judgment. However, expert perceptions of condition attributes used to classify these conditions may differ from those used by patients. To understand whether expert and patient perceptions differ, we asked women who had received preconception genetic carrier screening in the last 3 years to fill out a survey to rate the attributes (predictability, controllability, visibility, and severity) of several autosomal recessive or X-linked genetic conditions. These conditions were classified into one of five taxonomy categories developed by subject experts (significantly shortened lifespan, serious medical problems, mild medical problems, unpredictable medical outcomes, and adult-onset conditions). A total of 193 women provided 739 usable ratings across 20 conditions. The mean ratings and correlations demonstrated that participants made distinctions across both attributes and categories. Aggregated mean attribute ratings across categories demonstrated logical consistency between the key features of each attribute and category, although participants perceived little difference between the mild and serious categories. This study provides empirical evidence for the validity of our proposed taxonomy, which will simplify patient decisions for results they would like to receive from preconception carrier screening via genome sequencing

Generating a taxonomy for genetic conditions relevant to reproductive planning

As genome or exome sequencing (hereafter genome-scale sequencing) becomes more integrated into standard care, carrier testing is an important possible application. Carrier testing using genome-scale sequencing can identify a large number of conditions, but choosing which conditions/genes to evaluate as well as which results to disclose can be complicated. Carrier testing generally occurs in the context of reproductive decision-making and involves patient values in a way that other types of genetic testing may not. The Kaiser Permanente Clinical Sequencing Exploratory Research program is conducting a randomized clinical trial of preconception carrier testing that allows participants to select their preferences for results from among broad descriptive categories rather than selecting individual conditions. This paper describes 1) the criteria developed by the research team, the return of results committee (RORC), and stakeholders for defining the categories; 2) the process of refining the categories based on input from patient focus groups and validation through a patient survey; and, 3) how the RORC then assigned specific gene-condition pairs to taxonomy categories being piloted in the trial. The development of four categories (serious, moderate/mild, unpredictable, late onset) for sharing results allows patients to select results based on their values without separately deciding their interest in knowing their carrier status for hundreds of conditions. A fifth category, lifespan limiting, was always shared. The lessons learned may be applicable in other results disclosure situations, such as incidental findings