1,569 research outputs found

    Research, action and 'critical' geographies

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    In the 199Os, the notion of ‘doing’ critical geographies has become one of the central themes infusing human geographic study. Eschewing the strictures of radical Marxist approaches (which principally focused on the forms of oppression and inequality wrought by capitalist process), critical geography has consequently sought to examine the diverse sociospatial processes that regulate and reproduce social exclusion. The lens of critical geographers has thus widened from a narrow focus on capital-labour relations to encompass broader processes of social disadvantage and marginalization as they affect women, ethnic minorities, sexual dissidents, disabled people and so on. Simultaneously, this ’critical agenda’ has been accompanied by a heightened concern that the geographer’s research on social oppression and exclusion should be sensitive to the life experiences of marginalized groups. For example, in recent years there have been several papers (eg Keith 7992; Robinson 1994; Rose 1997) and collections (Canadian Geographer 1993; Professional Geographer 1994; Antipode 1995) that have examined issues such as reflexivity, empowerment, emancipation, critical praxis, positionality and power relations. Such writing has generally concentrated on the complex social relations the exist between researcher and researched, with ideas from feminist scholarship (in particular) invoked to dismiss assumptions that research is an objective and ‘value-free’ endeavour

    Predicting protein stability and solubility changes upon mutations: data perspective

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    Understanding mutational effects on protein stability and solubility is of particular importance for creating industrially relevant biocatalysts, resolving mechanisms of many human diseases, and producing efficient biopharmaceuticals, to name a few. Forin silicopredictions, the complexity of the underlying processes and increasing computational capabilities favor the use of machine learning. However, this approach requires sufficient training data of reasonable quality for making precise predictions. This minireview aims to summarize and scrutinize available mutational datasets commonly used for training predictors. We analyze their structure and discuss the possible directions of improvement in terms of data size, quality, and availability. We also present perspectives on the development of mutational data for accelerating the design of efficient predictors, introducing two new manually curated databases FireProt(DB)and SoluProtMut(DB)for protein stability and solubility, respectively

    Female Surfers Riding the Crest of a ‘New Wave’ of Irish National Identity

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    With surfing debuting at the 2021 Tokyo Olympics (postponed from summer 2020 due to the COVID 19 global pandemic) it is timely to consider surfing and the national identifications women in Ireland may have with this sport. As Lee Bush states, 'with so little scholarship on surfing women, descriptive studies are needed as a foundation for launching future interpretive and critical studies.' Twelve women who surf in Ireland spoke about the links their surfing may or may not have with their national identity. Previous academic inquiry on links between national identity and sport on the island of Ireland has almost exclusively focused on men's experiences of team sports and issues of 'Irishness'. 'Irishness' is globally recognised and stereotypically linked to traditional and indigenous Irish sports such as Gaelic football and a range of other cultural activities. Research into women's sport participation has largely been restricted to the study of soccer in the Republic of Ireland, and gendered evaluations of various lifestyle and health surveys. Katie Liston, a key researcher in sport and gender relations in Ireland, highlights that 'there seems to be an increasing diversity in the kinds of activities in which people participate in', and that there is a shift towards 'lifestyle' activities for adults as diversity increases in young people's participation in sports and leisure activities. Against the backdrop of Liston's work, this article delves deeper into data collected as part of a wider research project, discussing whether or not women who surf in Ireland do so as part of a process designed to construct and reflect their national identities related to this arguably 'postmodern' 'lifestyle sport', in which Ireland will be represented on the Olympic stage for the first time in 2021
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