119 research outputs found
Functorial properties of Putnam's homology theory for Smale spaces
We investigate functorial properties of Putnam's homology theory for Smale
spaces. Our analysis shows that the addition of a conjugacy condition is
necessary to ensure functoriality. Several examples are discussed that
elucidate the need for our additional hypotheses. Our second main result is a
natural generalization of Putnam's Pullback Lemma from shifts of finite type to
non-wandering Smale spaces.Comment: Updated to agree with published versio
A Multi-Faceted Approach to Enabling Large-Scale Science in a Microsat Constellation
The Polarimeter to UNify the Corona and Heliosphere (PUNCH) mission is a constellation of microsatellites that combines advances in several areas of technology enabling the use of simple imaging instrumentation to measure, to-date, inaccessible aspects of the outer corona and solar wind. The primary PUNCH measurement is brightness and polarization state of light scattered by electrons entrained in solar wind features. This measurement is made possible in the context of a small explorer budget by leveraging a combination of three key elements: (a) a constellation of four small satellites conducting synchronized observations, (b) availability of low-cost off-the-shelf components, and (c) advanced and rigorous science data processing that enables the four microsats to produce 3D images as a single virtual observatory. This paper will discuss the contribution of each of these key enablers, and present the overall status of this NASA Small Explorer mission scheduled for launch in 2025
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RNA aptamer delivery through intact human skin
It is generally recognised that only relatively small molecular weight (typically 100,000-fold) and aptamer integrity was confirmed using an oligonucleotide precipitation assay. A Th17 response was stimulated in freshly excised human skin resulting in significantly upregulated IL-17f, and 22; topical application of the IL-23 aptamer decreased both IL-17f and IL-22 by approximately 45% but did not result in significant changes to IL-23 mRNA levels, confirming that the aptamer did not globally suppress mRNA levels. This study demonstrates that very large molecular weight RNA aptamers can permeate across the intact human skin barrier to therapeutically relevant levels into both the epidermis and dermis and that the skin penetrating aptamer retains its biologically active conformational structure capable of binding to endogenous IL-23
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