394 research outputs found
A cross-sectional study about socio-demographic factors and clinical characteristics of male patients with alcohol dependence syndrome
Background: Alcohol abuse is one of the major causes of death and disability globally; and a key risk factor for health, social, and economic problems in the communities. Consumption of alcohol by Indians has increased drastically due to various factors and in an unrestricted manner; and the age of initiation of drinking is progressively coming down. Objective: To determine the socio-demographic and clinical profile of the patients coming for treatment of alcohol dependence syndrome in the psychiatry department. Methods: A cross-sectional study was conducted on 50 male outpatients of alcohol dependence syndrome attending the department of psychiatry at a tertiary care hospital. Sociodemographic data and clinical details were recorded with the help of a pre-designed questionnaire. Results: Nuclear family, family history of alcoholism, unmarried status, higher educational level, unemployment, and peer pressure are the factors significantly associated with early age at first drink and age of dependence on alcohol (p < 0.05). Conclusion: Adolescents having a family history of alcoholism are a high-risk group for developing alcohol dependence and should be targeted for intervention strategies. Community based-longitudinal studies are needed to understand multiple factors influencing alcohol use and recommend targeted preventive measures.
Keywords: Alcohol, Alcohol dependence syndrome, Peer pressure, Intoxication, Socio-demographic factor
A cross-sectional study about socio-demographic factors and clinical characteristics of male patients with alcohol dependence syndrome
Background: Alcohol abuse is one of the major causes of death and disability globally; and a key risk factor for health, social, and economic problems in the communities. Consumption of alcohol by Indians has increased drastically due to various factors and in an unrestricted manner; and the age of initiation of drinking is progressively coming down. Objective: To determine the socio-demographic and clinical profile of the patients coming for treatment of alcohol dependence syndrome in the psychiatry department. Methods: A cross-sectional study was conducted on 50 male outpatients of alcohol dependence syndrome attending the department of psychiatry at a tertiary care hospital. Sociodemographic data and clinical details were recorded with the help of a pre-designed questionnaire. Results: Nuclear family, family history of alcoholism, unmarried status, higher educational level, unemployment, and peer pressure are the factors significantly associated with early age at first drink and age of dependence on alcohol (p < 0.05). Conclusion: Adolescents having a family history of alcoholism are a high-risk group for developing alcohol dependence and should be targeted for intervention strategies. Community based-longitudinal studies are needed to understand multiple factors influencing alcohol use and recommend targeted preventive measures.
Keywords: Alcohol, Alcohol dependence syndrome, Peer pressure, Intoxication, Socio-demographic factor
Stochastic integration based on simple, symmetric random walks
A new approach to stochastic integration is described, which is based on an
a.s. pathwise approximation of the integrator by simple, symmetric random
walks. Hopefully, this method is didactically more advantageous, more
transparent, and technically less demanding than other existing ones. In a
large part of the theory one has a.s. uniform convergence on compacts. In
particular, it gives a.s. convergence for the stochastic integral of a finite
variation function of the integrator, which is not c\`adl\`ag in general.Comment: 16 pages, some typos correcte
Early IFNÎł-Mediated and Late Perforin-Mediated Suppression of Pathogenic CD4 T Cell Responses Are Both Required for Inhibition of Demyelinating Disease by CNS-Specific Autoregulatory CD8 T Cells
Pathogenesis of immune-mediated demyelinating diseases like multiple sclerosis (MS) is thought to be governed by a complex cellular interplay between immunopathogenic and immunoregulatory responses. We have previously shown that central nervous system (CNS)-specific CD8 T cells have an unexpected protective role in the mouse model of MS, experimental autoimmune encephalomyelitis (EAE). In this study, we interrogated the suppressive potential of PLP178-191-specific CD8 T cells (PLP-CD8). Here, we show that PLP-CD8, when administered post-disease onset, rapidly ameliorated EAE progression, and suppressed PLP178-191-specific CD4 T cell responses as measured by delayed-type hypersensitivity (DTH). To accomplish DTH suppression, PLP-CD8 required differential production of perforin and IFNÎł. Perforin was not required for the rapid suppressive action of these cells, but was critical for maintenance of optimal longer term DTH suppression. Conversely, IFNÎł production by PLP-CD8 was necessary for swift DTH suppression, but was less significant for maintenance of longer term suppression. These data indicate that CNS-specific CD8 T cells employ an ordered regulatory mechanism program over a number of days in vivo during demyelinating disease and have mechanistic implications for this immunotherapeutic approach
Tumor Necrosis Factor Receptor 1 Expression Is Upregulated in Dendritic Cells in Patients with Chronic HCV Who Respond to Therapy
The present studies assessed the level of tumor necrosis factor receptor (TNFR) expression in peripheral blood mononuclear cells (PBMCs) subsets from patients with chronic HCV undergoing interferon α/ribavirin-based therapy (Ifn/R). Methods. TNFR family member mRNA expression was determined using quantitative real-time PCR assays (RTPCRs) in PBMC from 39 HCV+ patients and 21 control HCVâ patients. Further subset analysis of HCV + patients (untreated (U), sustained virological responders (SVR), and nonresponders (NR)/relapsers (Rel)) PBMC was performed via staining with anti-CD123, anti-CD33, anti-TNFR1 or via RTPCR for TNFR1 mRNA. Results. A similar level of TNFR1 mRNA in PBMC from untreated HCV+ genotype 1 patients and controls was noted. TNFR1 and TNFR2 mRNA levels in PBMC from HCV+ patients with SVR were statistically different than levels in HCV(â) patients. A significant difference was noted between the peak values of TNFR1 of the CD123+ PBMC isolated from SVR and the NR/Rel. Conclusion. Upregulation of TNFR1 expression, occurring in a specific subset of CD123+ dendritic cells, appeared in HCV+ patients with SVR
The Parametric Ordinal-Recursive Complexity of Post Embedding Problems
Post Embedding Problems are a family of decision problems based on the
interaction of a rational relation with the subword embedding ordering, and are
used in the literature to prove non multiply-recursive complexity lower bounds.
We refine the construction of Chambart and Schnoebelen (LICS 2008) and prove
parametric lower bounds depending on the size of the alphabet.Comment: 16 + vii page
Frequency Dependence of Fatigue Life and Internal Heating of a Fiber-Reinforced/Ceramic-Matrix Composite
Peer Reviewedhttp://deepblue.lib.umich.edu/bitstream/2027.42/65943/1/j.1151-2916.1994.tb04587.x.pd
Integrated engineering environments for large complex products
An introduction is given to the Engineering Design Centre at the University of Newcastle upon Tyne, along with a brief explanation of the main focus towards large made-to-order products. Three key areas of research at the Centre, which have evolved as a result of collaboration with industrial partners from various sectors of industry, are identified as (1) decision support and optimisation, (2) design for lifecycle, and (3) design integration and co-ordination. A summary of the unique features of large made-to-order products is then presented, which includes the need for integration and co-ordination technologies. Thus, an overview of the existing integration and co-ordination technologies is presented followed by a brief explanation of research in these areas at the Engineering Design Centre. A more detailed description is then presented regarding the co-ordination aspect of research being conducted at the Engineering Design Centre, in collaboration with the CAD Centre at the University of Strathclyde. Concurrent Engineering is acknowledged as a strategy for improving the design process, however design coordination is viewed as a principal requirement for its successful implementation. That is, design co-ordination is proposed as being the key to a mechanism that is able to maximise and realise any potential opportunity of concurrency. Thus, an agentoriented approach to co-ordination is presented, which incorporates various types of agents responsible for managing their respective activities. The co-ordinated approach, which is implemented within the Design Co-ordination System, includes features such as resource management and monitoring, dynamic scheduling, activity direction, task enactment, and information management. An application of the Design Co-ordination System, in conjunction with a robust concept exploration tool, shows that the computational design analysis involved in evaluating many design concepts can be performed more efficiently through a co-ordinated approach
PREDICTION OF FATIGUE FAILURES OF ALUMINUM DISC WHEELS USING THE FAILURE PROBABILITY CONTOUR BASED ON HISTORICAL TEST DATA
Computing the -binomial complexity of the Thue--Morse word
Two words are -binomially equivalent whenever they share the same
subwords, i.e., subsequences, of length at most with the same
multiplicities. This is a refinement of both abelian equivalence and the Simon
congruence. The -binomial complexity of an infinite word maps
the integer to the number of classes in the quotient, by this -binomial
equivalence relation, of the set of factors of length occurring in
. This complexity measure has not been investigated very much. In
this paper, we characterize the -binomial complexity of the Thue--Morse
word. The result is striking, compared to more familiar complexity functions.
Although the Thue--Morse word is aperiodic, its -binomial complexity
eventually takes only two values. In this paper, we first obtain general
results about the number of occurrences of subwords appearing in iterates of
the form for an arbitrary morphism . We also thoroughly
describe the factors of the Thue--Morse word by introducing a relevant new
equivalence relation
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