NATURE INSPIRED SYNTHESIS, PHYSICO-CHEMICAL CHARACTERIZATION OF Zn DOPED Fe3O4 NANOPARTICLES USING ANDROGRAPHIS PANICULATA (BURM. F.) NEES LEAF EXTRACT AND ASSESSMENT OF IN VITRO PANCREATIC ALPHA AMYLASE INHIBITORY ACTIVITY

Objective: Magnetite (Fe3O4) nanoparticles (NPs) have gained considerable attention in the Biomedical filed. Evolution of new magnetic material based on the transition metal-doped magnetite has become the subject of increasing research interest. The main aim of the current investigation was to improve the diabetic potential, optical, magnetic, structural properties of magnetite nanoparticles and hence Fe3O4 NPs were doped with a divalent transition element such as Zinc. Methods: Zinc doped magnetite nanoparticles (Zn-Fe3O4 NPs) were obtained through Co-precipitation methods using aqueous plant extract of Andrographis paniculata acted as an efficient stabilizer and a reducing agent. The structure, morphology, crystalline, optical and magnetic property of synthesized Zn-Fe3O4 NPs were evaluated by X-ray diffraction (XRD), Scanning electron microscopy with Energy dispersive x-ray spectroscopy(SEM-EDX), Fourier transform infrared spectroscopy (FTIR), Ultraviolet-Visible (UV-Vis) Spectrophotometer and Vibrating scanning magnetometer (VSM). Results: In XRD analysis, the average crystallite size of the synthesized Zn-Fe3O4 NPs was found to be 5 nm exhibiting super paramagnetic behavior, which composes it an appealing possibility for biomedicines. The Zn-Fe3O4 NPs had strongly inhibited the alpha (α)-amylase enzyme and had proved their therapeutic role. Conclusion: In conclusion, Zn-Fe3O4 NPs is an excellent anti-diabetic agent to control type 2 diabetes mellitus

INTERACTION OF TWO FLAVONOIDS WITH CALF THYMUS DNA: A MULTI - SPECTROSCOPIC, ELECTROCHEMICAL AND MOLECULAR MODELLING APPROACH

Interaction of naturally occurring bioactive flavonoids 5,6,7-trihydroxyflavone (Baicalein) and 7,8-dihydroxyflavone (DHF) binding with calf thymus deoxyribose nucleic acid (dsDNA) was studied by employing UV absorption, fluorescence, circular dichroism, cyclic voltammetric and molecular modeling techniques. All studies were confirmed that the structural changes of DNA binding to the flavonoid. From the CV results positive shift in peak potential and increased peak current of the flavonoid in the presence of DNA and then the fluorescence quenching of DNA-flavonoids system indicated the intercalative mode of binding between flavonoid and DNA. CD studies suggest the conformational changes in DNA upon interaction with the flavonoids. Molecular docking simulation methods are used as tools to delineate the binding mode and probable location of the flavonoids and their effects on the stability and conformation of Ct-(ds) DNA. Furthermore, Baicalein can bind with more potential with Ct-(ds) DNA than DHF. This is helpful to understand the molecular aspects of binding mode and provides direction for the use and the design of new effective therapeutic agents. These results could provide useful information for insight into the pharmacological mechanism of flavonoids

The effect of Zn2+ ion in promoting inhibitive property of phenolphthalein

The inhibition efficiency of phenolphthalein in controlling corrosion of carbon steel immersed in well water has been evaluatedby mass loss method both in absence and presence of zinc ion. A synergistic effect exists between phenolphthalein (PN)and Zn2+. The inhibition efficiency (IE) of the PN – Zn2+ system decreases with increase in immersion period. Addition ofN-Cetyl-N, N, N-Trimethylammlonium bromide (CTAB) sodium dodecyl sulphate (SDS), sodium sulphite (Na2SO3) doesnot change the excellent inhibition efficiency of the PN-Zn2+ system. Polarization study suggests that the Pn-Zn2+ systemfunctions as a mixed inhibitor system. AC impedance spectra reveal the presence of a protective film on the metal surface.FTIR spectra indicate that the protective film consists of Fe2+-PN complex and Zn(OH)2

PORTUGALIAE ELECTROCHIMICA ACTA Inhibition of Corrosion of Carbon Steel in Sea Water by Sodium Gluconate -Zn 2+ System

Abstract The inhibition efficiency of sodium gluconate (SG)-Zn 2+ system in controlling corrosion of carbon steel in sea water has been evaluated by weight-loss method. The formulation consisting of 250 ppm of SG and 75 ppm of Zn 2+ has 98% IE. Influence of duration of immersion on the IE of SG-Zn 2+ has been evaluated. The mechanistic aspects of corrosion inhibition have been investigated by polarization study and AC impedance spectra. The protective film has been analysed by FTIR and luminescence spectra. The surface morphology and the roughness of the metal surface have been analysed by atomic force microscopy. The protective film consists of Fe 2+ -SG complex and Zn(OH) 2 . It is found to be UV -fluorescent