Resilience markers for safer systems and organisations

If computer systems are to be designed to foster resilient performance it is important to be able to identify contributors to resilience. The emerging practice of Resilience Engineering has identified that people are still a primary source of resilience, and that the design of distributed systems should provide ways of helping people and organisations to cope with complexity. Although resilience has been identified as a desired property, researchers and practitioners do not have a clear understanding of what manifestations of resilience look like. This paper discusses some examples of strategies that people can adopt that improve the resilience of a system. Critically, analysis reveals that the generation of these strategies is only possible if the system facilitates them. As an example, this paper discusses practices, such as reflection, that are known to encourage resilient behavior in people. Reflection allows systems to better prepare for oncoming demands. We show that contributors to the practice of reflection manifest themselves at different levels of abstraction: from individual strategies to practices in, for example, control room environments. The analysis of interaction at these levels enables resilient properties of a system to be ‘seen’, so that systems can be designed to explicitly support them. We then present an analysis of resilience at an organisational level within the nuclear domain. This highlights some of the challenges facing the Resilience Engineering approach and the need for using a collective language to articulate knowledge of resilient practices across domains

GaBoDS: The Garching-Bonn Deep Survey VIII. Lyman-break galaxies in the ESO Deep Public Survey

Aims. The clustering properties of a large sample of U-dropouts are investigated and compared to very precise results for B-dropouts from other studies to identify a possible evolution from z=4 to z=3. Methods. A population of ~8800 candidates for star-forming galaxies at z=3 is selected via the well-known Lyman-break technique from a large optical multicolour survey (the ESO Deep Public Survey). The selection efficiency, contamination rate, and redshift distribution of this population are investigated by means of extensive simulations. Photometric redshifts are estimated for every Lyman-break galaxy (LBG) candidate from its UBVRI photometry yielding an empirical redshift distribution. The measured angular correlation function is deprojected and the resulting spatial correlation lengths and slopes of the correlation function of different subsamples are compared to previous studies. Results. By fitting a simple power law to the correlation function we do not see an evolution in the correlation length and the slope from other studies at z=4 to our study at z=3. In particular, the dependence of the slope on UV-luminosity similar to that recently detected for a sample of B-dropouts is confirmed also for our U-dropouts. For the first time number statistics for U-dropouts are sufficient to clearly detect a departure from a pure power law on small scales down to ~2" reported by other groups for B-dropouts.Comment: 10 pages, 11 figures, accepted by A&A, full resolution version available at http://www.astro.uni-bonn.de/~hendrik/5880.pd

Impact of tumor-specific targeting on the biodistribution and efficacy of siRNA nanoparticles measured by multimodality in vivo imaging

Targeted delivery represents a promising approach for the development of safer and more effective therapeutics for oncology applications. Although macromolecules accumulate nonspecifically in tumors through the enhanced permeability and retention (EPR) effect, previous studies using nanoparticles to deliver chemotherapeutics or siRNA demonstrated that attachment of cell-specific targeting ligands to the surface of nanoparticles leads to enhanced potency relative to nontargeted formulations. Here, we use positron emission tomography (PET) and bioluminescent imaging to quantify the in vivo biodistribution and function of nanoparticles formed with cyclodextrin-containing polycations and siRNA. Conjugation of 1,4,7,10-tetraazacyclododecane-1,4,7,10-tetraacetic acid to the 5' end of the siRNA molecules allows labeling with 64Cu for PET imaging. Bioluminescent imaging of mice bearing luciferase-expressing Neuro2A s.c. tumors before and after PET imaging enables correlation of functional efficacy with biodistribution data. Although both nontargeted and transferrin-targeted siRNA nanoparticles exhibit similar biodistribution and tumor localization by PET, transferrin-targeted siRNA nanoparticles reduce tumor luciferase activity by {approx}50% relative to nontargeted siRNA nanoparticles 1 d after injection. Compartmental modeling is used to show that the primary advantage of targeted nanoparticles is associated with processes involved in cellular uptake in tumor cells rather than overall tumor localization. Optimization of internalization may therefore be key for the development of effective nanoparticle-based targeted therapeutics

Regional variation in digital cushion pressure in the forefeet of horses and elephants

In this study, we seek to understand how the digital cushion morphologies evident in horse and elephant feet influence internal and external foot pressures. Our novel use of invasive blood pressure monitoring equipment, combined with a pressure pad and force plate, enabled measurements of (ex vivo) digital cushion pressure under increasing axial loads in seven horse and six elephant forefeet. Linear mixed effects models (LMER) revealed that internal digital cushion pressures increase under load and differ depending on region; elephant feet experienced higher magnitudes of medial digital cushion pressure, whereas horse feet experienced higher magnitudes of centralised digital cushion pressure. Direct comparison of digital cushion pressure magnitudes in both species, at equivalent loads relative to body weight, revealed that medial and lateral pressures increased more rapidly with load in elephant limbs. Within the same approximate region, internal pressures exceeded external, palmar pressures (on the sole of the foot), supporting previous Finite Element (FE) predictions. High pressures and large variations in pressure may relate to the development of foot pathology, which is a major concern in horses and elephants in a captive/domestic environment

Evaluation of two thermal neutron detection units consisting of ZnS/6{}^6LiF scintillating layers with embedded WLS fibers read out with a SiPM

Two single channel detection units for thermal neutron detection are investigated in a neutron beam. They consist of two ZnS/${}^6$LiF scintillating layers sandwiching an array of WLS fibers. The pattern of this units can be repeated laterally and vertically in order to build up a one dimensional position sensitive multi-channel detector with the needed sensitive surface and with the required neutron absorption probability. The originality of this work arises from the fact that the WLS fibers are read out with SiPMs instead of the traditionally used PMTs or MaPMTs. The signal processing system is based on a photon counting approach. For SiPMs with a dark count rate as high as 0.7 MHz, a trigger efficiency of 80% is achieved together with a system background rate lower than ${10}^{-3}$ Hz and a dead time of 30 $\mu$s. No change of performance is observed for neutron count rates of up to 3.6 kHz.Comment: Submitted to Nuclear Instruments and Methods