99 research outputs found
{Tc(NO)(Cp)(PPh3)}+ – a novel technetium(I) core
Reactions between [TcI(NO)X2(PPh3)2(CH3CN)] complexes (X = Cl, Br) and KCp
form the pseudotetrahedral organotechnetium compounds [TcI(NO)(Cp)(PPh3)X].
The halide ligands can readily be replaced by other halides or organometallic
ligands giving access to a novel family of technetium(I) compounds with the
robust {Tc(NO)(Cp)(PPh3)}+ core
5′′-(4-Chlorobenzylidene)-4′-(4-chlorophenyl)-5-fluoro-1′,1′′-dimethylindoline-3-spiro-2′-pyrrolidine-3′-spiro-3′′-piperidine-2,4′′-dione
The piperidine ring of the title compound, C30H26Cl2FN3O2, adopts a twisted chair conformation. The pyrrolidine ring has a twisted envelope structure with the N atom at the flap [displaced by 0.592 (3) Å]. The fluorooxindole, chlorophenyl and chlorobenzylidene groups are planar with r.m.s. deviations of 0.0348, 0.0048 and 0.0048 Å, respectively. The structure is stabilized by intermolecular N—H⋯O hydrogen bonds
Novel zwitterionic oxorhenium(V) complexes: synthesis, characterization and crystal structure of [ReOX2(Hdhp)(PPh3)] (X = Cl, Br; H2dhp = 2,3-dihydroxypyridine)
Is No News (Perceived as) Bad News? An Experimental Investigation of Information Disclosure
Zur experimentellen Chemotherapie der Isonicotinsäurehydrazid (INH)-resistenten Tuberkulose
Thiourea derivatives as chelating agents for bioconjugation of rhenium and technetium
Potential tetradentate thiocarbamoylbenzamidine derivatives H4L have been synthesized from the corresponding benzimidoyl chlorides and triglycine. They are suitable chelating agents for the oxidotechnetium(V) and oxidorhenium(V) cores and form stable, neutral [MO(HL)] complexes with an equatorial SN3 coordination sphere and an additional, uncoordinated carboxylic group, which can be used for bioconjugation. Representatives of the rhenium and Tc-99 products have been isolated and analyzed with spectroscopic methods and X-ray diffraction. Bioconjugates of these complexes with angiotensin-II have been synthesized and structurally characterized. Analogous (99)mTc complexes have been produced and tested in vitro and in vivo. The experiments confirm a considerable stability for the [(99)mTc(HL)] product as well as for its bioconjugate and recommend this class of compounds for further bioconjugation studies towards clinical applications
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