Understanding Vehicular Mobility in Network Simulation

Abstract—Within the extent of recent research activity in the field of vehicular networking, notwithstanding the quantity of simulative studies carried out on protocols performance, the impact of vehicular mobility characterization has been often overlooked. Realistic mobility models are seldom employed, and when used, no comment is usually provided on the different effects that such models have on the results with respect to simpler mobility descriptions. In this paper, we address this issue, and analyze the impact that various levels of details in vehicular mobility modeling have on the simulation of networking protocols. I

MAGI1 Prevents Senescence and Promotes the DNA Damage Response in ER+ Breast Cancer.

MAGI1 acts as a tumor suppressor in estrogen receptor-positive (ER <sup>+</sup> ) breast cancer (BC), and its loss correlates with a more aggressive phenotype. To identify the pathways and events affected by MAGI1 loss, we deleted the MAGI1 gene in the ER <sup>+</sup> MCF7 BC cell line and performed RNA sequencing and functional experiments in vitro. Transcriptome analyses revealed gene sets and biological processes related to estrogen signaling, the cell cycle, and DNA damage responses affected by MAGI1 loss. Upon exposure to TNF-α/IFN-γ, MCF7 MAGI1 KO cells entered a deeper level of quiescence/senescence compared with MCF7 control cells and activated the AKT and MAPK signaling pathways. MCF7 MAGI1 KO cells exposed to ionizing radiations or cisplatin had reduced expression of DNA repair proteins and showed increased sensitivity towards PARP1 inhibition using olaparib. Treatment with PI3K and AKT inhibitors (alpelisib and MK-2206) restored the expression of DNA repair proteins and sensitized cells to fulvestrant. An analysis of human BC patients' transcriptomic data revealed that patients with low MAGI1 levels had a higher tumor mutational burden and homologous recombination deficiency. Moreover, MAGI1 expression levels negatively correlated with PI3K/AKT and MAPK signaling, which confirmed our in vitro observations. Pharmacological and genomic evidence indicate HDACs as regulators of MAGI1 expression. Our findings provide a new view on MAGI1 function in cancer and identify potential treatment options to improve the management of ER <sup>+</sup> BC patients with low MAGI1 levels

Contactless power interface for plug-in electric vehicles in V2G systems

In the paper a bi-directional power electronic interface based on an inductive coupled contactless energy transfer system for plug-in vehicles with Vehicle-to-Grid (V2G) capability is presented. To minimize the total losses of the system, a series resonant compensation circuit is applied assuring Near to Zero-Current Switching (N2ZCS) condition for insulated-gate bipolar transistors. The analytical expression of the dc voltage and current gains as well as energy transfer efficiency is given and discussed. The system uses modified FPGA based integral control method adjusting resonant frequency and guarantees very fast and stable operation. Simulation and experimental results illustrating properties of the developed 40-60kHz switching frequency operated 15kW laboratory prototype are presented

On Lightweight Intrusion Detection: Modeling and Detecting Intrusions Dedicated to OLSR Protocol

International audienc