55 research outputs found

    Risk auto theft: Predicting spatial distributions of crime events

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    Police typically rely on retrospective hotspot maps to informe prevention strategies aimed at reducing future crime. The current study reviews environmental crime theories that help to identify casual factors associated with rish of auto theft. Map layers are created from data that operationalize these risk factors. These layers are combined using spatial analysis techniques to produce a risk density map. Analysis of crime data are used to determing wheter our risk density map better predicts subsequetnt theft events than a traditional retrospective hotspot map

    Effects of Growing-Season Prescribed Burning on Vigor of the Noxious Weed Sericea Lespedeza (Lespedeza cuneata) in the Kansas Flint Hills

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    Sericea lespedeza (SL) was introduced into the United States from Asia in the late 19th century. Early land managers recognized that SL was adaptable; tolerant of shallow, acidic or low-fertility soils; and resistant to insects and disease. This combination of traits made SL a widely-used plant for reseeding strip-mined lands, highway right-ofways, dams, and waterways in the US for nearly a century. Regrettably, SL is highly fecund. Individual plants are capable of producing up to 850 lb of seed per acre annually. Vigorous seed production allows SL to rapidly infiltrate native grasslands that are adjacent to reseeding projects; seed can be transported great distances via the alimentary canal and hair of wild and domestic herbivores. In Kansas alone, SL has infested approximately 980 square miles of pasture, primarily in the Flint Hills region. The resulting damage to native habitats for wildlife and pasture quality for domestic herbivores has been devastating. The predominant grazing management practice in the Kansas Flint Hills involves annual spring burning in March or April, followed by intensive grazing with yearling beef cattle for a relatively short period from April to August. During seasonal grazing, 40 to 60% of annual graminoid production is removed and grazing lands then remain idle for the remainder of the year. Under this prevailing management practice, invasion by SL into the Tallgrass Prairie biome has steadily increased. Oklahoma State University researchers speculated that dormant-season, spring fires may stimulate SL growth by scarifying seeds lying on the surface of the soil. In contrast, plants with robust canopies respond more strongly to growing-season prescribed burns than to dormant-season prescribed burns. Previous research reported that application of growing season fire at 3-yr intervals decreased the rate of SL invasion. Therefore, the objective of our study was to evaluate the effects of growing-season prescribed burning of native tallgrass range on vigor of sericea lespedeza

    Effects of Intensive Late-Season Sheep Grazing Following Early-Season Steer Grazing on Population Dynamics of Sericea Lespedeza in the Kansas Flint Hills

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    Sericea lespedeza (Lespedeza cuneata; SL) is a high-tannin, invasive forb in the Tallgrass Prairie ecosystem. In Kansas, sericea lespedeza infests 980 square miles of pasture, primarily in the Flint Hills region. Sericea lespedeza infestations reduce native grass production by up to 92% through a combination of aggressive growth, prolific reproduction, canopy dominance, and chemical inhibition (allelopathy). Herbicides retard the spread of sericea lespedeza, but application is laborious and expensive; moreover, herbicides are lethal to ecologically-important, non-target plant species. Increased grazing pressure on sericea lespedeza by domestic herbivores may slow its spread and facilitate some measure of biological control. Unfortunately, mature plants contain high levels of condensed tannins, which are a strong deterrent to grazing by beef cattle. Small ruminants have greater tolerance for condensed tannins than beef cattle. Sheep, in particular, appear less susceptible to certain plant toxins than beef cattle and may be useful to selectively pressure noxious weeds like sericea lespedeza. The predominant grazing management practice in the Flint Hills region of Kansas involves annual spring burning followed by intensive grazing with yearling beef cattle from April to August. During seasonal grazing, 40 to 60% of annual graminoid production is removed and pastures remain idle for the remainder of the year. Under this prevailing management practice, invasion by sericea lespedeza into the Tallgrass Prairie biome has steadily increased. Sericea lespedeza flowers and produces seed in late summer from August to September. The absence of grazing pressure during this interval strongly promotes seed production, seed distribution, and continued invasion of the Flint Hills ecoregion by this noxious weed. Therefore, the objective of our study was to evaluate effects of late-season sheep grazing following locally-conventional steer grazing on vigor and reproductive capabilities of sericea lespedeza

    Do all bunions need surgery? An investigation of Google searches for Hallux Valgus

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    Introduction: Hallux valgus (HV) or a bunion is one of the most common forefoot deformities. Approximately one in four adults will develop HV with a higher prevalence in adult females. Given the high prevalence of HV along with the wide variety of non-surgical and surgical treatment options for it, we believe patients are likely turning to internet search engines for questions germane to HV. Previous orthopaedic investigations have used Google’s “People Also Ask” box to characterize frequently asked questions (FAQs) regarding total knee and hip arthroplasty. Yet, no such investigation has been conducted for HV. Using Google’s Frequently Asked Questions (FAQs), we sought to classify these questions as well as assess their levels quality and transparency.Methods: On October 9, 2022, we searched Google using these four phrases: “Hallux Valgus Treatment,” “Hallux Valgus Treatment Surgery,” “Bunion Treatment,” and “Bunion Surgery.” We refreshed search results until a minimum of 100 FAQs were produced; we extracted the sources of these 100 questions for content analysis. Information transparency was assessed using the Journal of the American Medical Association’s (JAMA) Benchmark tool, question classification was defined using the Rothwell Classification of Questions, and information quality was assessed using Brief DISCERN. This study was approved by an IRB.Results section: Our Google search returned 299 unique FAQs after removing duplicates and unrelated FAQs. The majority were classified as fact based questions (149/299, 49.8%), followed by value (92/299, 30.8%) and policy questions (58/299, 19.4%). Overall the most common topic searched was related to the evaluation of treatment or surgery (79/299, 26.4%). The frequent answer sources were medical practices (158/299, 52.8%), followed by commercial (69/299, 23.1%) and academic (38/299, 12.7%). The one-way analysis of variance revealed a significant difference in mean quality scores among the 5 source types (F= 54.49, P<.001) with medical practices averaging the worst score (12.1/30) compared to academic sources which were found to have the highest score (21.8/30).Discussion: Patients seeking online information concerning treatment options for HV appear to search Google for questions related to treatment efficacy and restrictions. The most common source type encountered by patients are small medical practices; these were found to have both poor transparency and poor quality. Our study has several limitations, JAMA benchmark and Brief DISCERN do not assess the accuracy of the information. Secondly, our study is cross-sectional in design limiting the generalizability of our findings to the time when the search was performed.Significance/Clinical Relevance: In order to increase the transparency and quality of online information regarding HV treatment, online sources should refer to established rubrics such as JAMA benchmark and Brief DISCERN when publishing online information. Physicians should be aware that patients are commonly searching for information related to the evaluation of treatments or surgeries for HV

    Upregulation of complement proteins in lung cancer cells mediates tumor progression

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    IntroductionIn vivo, cancer cells respond to signals from the tumor microenvironment resulting in changes in expression of proteins that promote tumor progression and suppress anti-tumor immunity. This study employed an orthotopic immunocompetent model of lung cancer to define pathways that are altered in cancer cells recovered from tumors compared to cells grown in culture.MethodsStudies used four murine cell lines implanted into the lungs of syngeneic mice. Cancer cells were recovered using FACS, and transcriptional changes compared to cells grown in culture were determined by RNA-seq.ResultsChanges in interferon response, antigen presentation and cytokine signaling were observed in all tumors. In addition, we observed induction of the complement pathway. We previously demonstrated that activation of complement is critical for tumor progression in this model. Complement can play both a pro-tumorigenic role through production of anaphylatoxins, and an anti-tumorigenic role by promoting complement-mediated cell killing of cancer cells. While complement proteins are produced by the liver, expression of complement proteins by cancer cells has been described. Silencing cancer cell-specific C3 inhibited tumor growth In vivo. We hypothesized that induction of complement regulatory proteins was critical for blocking the anti-tumor effects of complement activation. Silencing complement regulatory proteins also inhibited tumor growth, with different regulatory proteins acting in a cell-specific manner.DiscussionBased on these data we propose that localized induction of complement in cancer cells is a common feature of lung tumors that promotes tumor progression, with induction of complement regulatory proteins protecting cells from complement mediated-cell killing

    The James Webb Space Telescope Mission

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    Twenty-six years ago a small committee report, building on earlier studies, expounded a compelling and poetic vision for the future of astronomy, calling for an infrared-optimized space telescope with an aperture of at least 4m4m. With the support of their governments in the US, Europe, and Canada, 20,000 people realized that vision as the 6.5m6.5m James Webb Space Telescope. A generation of astronomers will celebrate their accomplishments for the life of the mission, potentially as long as 20 years, and beyond. This report and the scientific discoveries that follow are extended thank-you notes to the 20,000 team members. The telescope is working perfectly, with much better image quality than expected. In this and accompanying papers, we give a brief history, describe the observatory, outline its objectives and current observing program, and discuss the inventions and people who made it possible. We cite detailed reports on the design and the measured performance on orbit.Comment: Accepted by PASP for the special issue on The James Webb Space Telescope Overview, 29 pages, 4 figure

    Criminal and Scientific Evidence: Cases, Materials and Problems. 2nd Edition.

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    https://scholarship.law.nd.edu/law_books/1214/thumbnail.jp

    Criminal and Scientific Evidence: Cases, Materials and Problems. 2nd Edition.

    No full text
    https://scholarship.law.nd.edu/law_books/1214/thumbnail.jp

    Criminal and Forensic Evidence: Cases, Materials, Problems

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    This unique casebook adopts a modern, comprehensive approach to the study of evidence issues that arise in the context of criminal trial litigation. It covers evidentiary issues associated with the admission of forensic evidence, including expert testimony, as well as traditional evidence issues, such as evidence of prior bad acts offered for purposes other than to prove propensity, and evidence of a rape victim\u27s prior sexual behavior. The materials are presented in two parts that allow for a Criminal Evidence course focused solely on forensic science, solely on traditional criminal evidentiary issues, or a combination of both topics. The Third Edition provides students the most current and comprehensive examination of the Supreme Court\u27s Sixth Amendment Confrontation Clause jurisprudence emanating from its recent decisions inCrawford v. Washington, Davis v. Washington, Giles v. California, and Melendez-Diaz v. Massachusetts. The new edition includes an extensive analysis of how federal and state courts post-Crawford have applied the Supreme Court\u27s testimonial evidence and primary purpose tests for determining whether the admission of hearsay statements violates the Sixth Amendment right of confrontation.https://scholarship.law.nd.edu/law_books/1051/thumbnail.jp
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