Resolution of inflammation: a new therapeutic frontier

Dysregulated inflammation is a central pathological process in diverse disease states. Traditionally, therapeutic approaches have sought to modulate the pro- or anti-inflammatory limbs of inflammation, with mixed success. However, insight into the pathways by which inflammation is resolved has highlighted novel opportunities to pharmacologically manipulate these processes — a strategy that might represent a complementary (and perhaps even superior) therapeutic approach. This Review discusses the state of the art in the biology of resolution of inflammation, highlighting the opportunities and challenges for translational research in this field

H2S biosynthesis and catabolism: new insights from molecular studies

Hydrogen sulfide (H2S) has profound biological effects within living organisms and is now increasingly being considered alongside other gaseous signalling molecules, such as nitric oxide (NO) and carbon monoxide (CO). Conventional use of pharmacological and molecular approaches has spawned a rapidly growing research field that has identified H2S as playing a functional role in cell-signalling and post-translational modifications. Recently, a number of laboratories have reported the use of siRNA methodologies and genetic mouse models to mimic the loss of function of genes involved in the biosynthesis and degradation of H2S within tissues. Studies utilising these systems are revealing new insights into the biology of H2S within the cardiovascular system, inflammatory disease, and in cell signalling. In light of this work, the current review will describe recent advances in H2S research made possible by the use of molecular approaches and genetic mouse models with perturbed capacities to generate or detoxify physiological levels of H2S gas within tissue

Risk of diabetes after para-aortic radiation for testicular cancer

Background: While the risk of diabetes is increased following radiation exposure to the pancreas among childhood cancer survivors, its association among testicular cancer (TC) survivors has not been investigated. Methods: Diabetes risk was studied in 2998 1-year TC survivors treated before 50 years of age with orchidectomy with/without radiotherapy between 1976 and 2007. Diabetes incidence was compared with general population rates. Treatment-specific risk of diabetes was assessed using a case–cohort design. Results: With a median follow-up of 13.4 years, 161 TC survivors were diagnosed with diabetes. Diabetes risk was not increased compared to general population rates (standardised incidence ratios (SIR): 0.9; 95% confidence interval (95% CI): 0.7–1.1). Adjusted for age, para-aortic radiotherapy was associated with a 1.66-fold (95% CI: 1.05–2.62) increased diabetes risk compared to no radiotherapy. The excess hazard increased with 0.31 with every 10 Gy increase in the prescribed radiation dose (95% CI: 0.11–0.51, P = 0.003, adjusted for age and BMI); restricted to irradiated patients the excess hazard increased with 0.33 (95% CI: −0.14 to 0.81, P = 0.169) with every 10 Gy increase in radiation dose. Conclusion: Compared to surgery only, para-aortic irradiation is associated with increased diabetes risk among TC survivors

Transport sector transformation: integrating electric vehicles in Turkey's distribution grids

This study investigates the impacts of integrating electrical vehicles to pilot distribution grids in Turkey to quantify technical concerns and solutions for the year 2030. Different charging loads that discern home, workplace and public charging are considered under two different cases; “home-charging-support” and “public-charging-support.” Random variables describing arrival time of electrical vehicles to the charging stations and associated state of charge at arrival time are modeled with a stochastic approach. Dependencies of electrical vehicle integration capacities of the pilot regions are investigated quantitatively based on several key performance indices. The study also analyzes effects on key performance indicators of demand response by electrical vehicle users, defined as smart charging. Key results show that there is sufficient capacity in the four selected Turkish distribution grids to integrate almost 10% electrical vehicles in the vehicle stock by 2030. Based on the results, priority areas are outlined for stakeholders including energy policymakers

De delectu oblectamentorum recreationis, dissertatio; quam suffrag. ampliss. facult. philos. Ups. sub moderamine doct. Dan. Boëthii ... publico examini modeste subjicit Daniel Hvasser, alumnus regius, Westmannus. In audit. Gust. maj. die XX Maji MDCCI. h. c.

This chapter details the findings from a national project that investigated the efficacy of the enabling program pathway into higher education for disadvantaged student groups. Enabling programs are not-for-degree programs designed to provide the necessary academic and cultural scaffolding for students who do not meet the institution's usual admissions criteria. The brief given to the project team was to undertake a review of current enabling programs offered by Australian higher education providers and report on the extent to which these courses were effective in increasing access and participation to, and subsequent success in, undergraduate courses for domestic students from disadvantaged groups. This chapter focuses specifically on the findings relevant to Indigenous students, who represent one of six officially recognised equity groups of students in Australian higher education policy. In this chapter the authors detail and discuss the nature and design of enabling programs for Indigenous students, and then provide a detailed analysis of the first year retention and success rates for Indigenous students who transitioned to undergraduate studies via these enabling programs. The evidence from the study indicates that Indigenous enabling pathways provide an important and effective environment in which the students develop a sense of belonging in higher education and develop the necessary resilience to persist in their subsequent studies. However, it is less clear whether Indigenous students are receiving the academic skills development necessary to succeed in their studies at rates similar to other students