10 research outputs found
Effects of resveratrol, curcumin, berberine and other nutraceuticals on aging, cancer development, cancer stem cells and microRNAs.
Natural products or nutraceuticals have been shown to elicit antiâaging, antiâcancer and other healthâenhancing
effects. A key target of the effects of natural products may be the regulation of microRNA (miR) expression
which results in cell death or prevents aging, diabetes, cardiovascular and other diseases. This review will focus
on a few natural products, especially on resveratrol (RES), curcumin (CUR) and berberine (BBR). RES is obtained
from the skins of grapes and other fruits and berries. RES may extend human lifespan by activating the sirtuins
and SIRT1 molecules. CUR is isolated from the root of turmeric (Curcuma longa). CUR is currently used in the treatment of many disorders, especially in those involving an inflammatory process. CUR and modified
derivatives have been shown to have potent antiâcancer effects, especially on cancer stem cells (CSC). BBR is
also isolated from various plants (e.g., Coptis chinensis) and has been used for centuries in traditional medicine
to treat diseases such as adultâ onset diabetes. Understanding the benefits of these and other nutraceuticals
may result in approaches to improve human health