Rapid Cycling and Exceptional Yield in a Metal-Organic Framework Water Harvester.

Sorbent-assisted water harvesting from air represents an attractive way to address water scarcity in arid climates. Hitherto, sorbents developed for this technology have exclusively been designed to perform one water harvesting cycle (WHC) per day, but the productivities attained with this approach cannot reasonably meet the rising demand for drinking water. This work shows that a microporous aluminum-based metal-organic framework, MOF-303, can perform an adsorption-desorption cycle within minutes under a mild temperature swing, which opens the way for high-productivity water harvesting through rapid, continuous WHCs. Additionally, the favorable dynamic water sorption properties of MOF-303 allow it to outperform other commercial sorbents displaying excellent steady-state characteristics under similar experimental conditions. Finally, these findings are implemented in a new water harvester capable of generating 1.3 L kgMOF -1 day-1 in an indoor arid environment (32% relative humidity, 27 °C) and 0.7 L kgMOF -1 day-1 in the Mojave Desert (in conditions as extreme as 10% RH, 27 °C), representing an improvement by 1 order of magnitude over previously reported devices. This study demonstrates that creating sorbents capable of rapid water sorption dynamics, rather than merely focusing on high water capacities, is crucial to reach water production on a scale matching human consumption

Autoantibody detection for diagnosis in direct immunofluorescence negative mucous membrane pemphigoid: ocular and other sites compared

Objective: To assess whether a panel of serum pemphigoid autoantibody tests could be used to confirm an immunopathological diagnosis of mucous membrane pemphigoid (MMP) in direct immunofluorescent negative (DIF-) MMP patients. / Design: Prospective cross-sectional study. / Subjects and controls: 76 patients with MMP involving ocular and non-ocular sites with 45 matched controls. / Tests: Enzyme linked immunosorbent assays (ELISA) for BP180 and BP230 (MBL International®), IgA and IgG indirect immunofluorescence on human salt-split skin (IIF SSS) and the keratinocyte footprint assay for anti-laminin 332 antibodies. / Main outcome measures: Sensitivity and specificity of autoantibody detection; significant differences for individual tests and test combinations for MMP involving different sites. / Results: All DIF- Cases (24/76, 31.8%) had either ocular only disease or ocular involvement in multi-site disease. Serum pemphigoid autoantibodies were detected in 29/76 (38.2%) of all MMP patients compared to 3/45 (6.7%) of controls. Autoantibody reactivity detected by any one or more of the tests was present in 6/24 (25%) DIF- cases compared to 22/49 (44.9%) in DIF positive (DIF+). Compared to controls ocular only MMP serum reactivity was not significantly different for any test or test combination whereas DIF- multisite ocular MMP differed for one ELISA and 3/7 test combinations. By contrast, for DIF+ non ocular MMP all the individual tests, apart from IgA IIF, and all test combinations were significantly different compared to controls. For the whole MMP cohort the sensitivity of all tests was low having a maximum of 21.05% for BP180 reactivity, increasing to 38.16% for an optimal test combination. Disease activity was strongly associated with positive serology findings. / Conclusions: Pemphigoid serum autoantibody tests did not provide alternative immunopathological evidence of MMP in ocular only MMP patients but had limited value in DIF- multisite ocular MMP. The requirement for immunopathological confirmation of MMP by autoantibody detection is inappropriate for DIF- ocular only MMP resulting in missed diagnoses, delayed therapy and poor outcomes. Alternative diagnostic criteria for MMP with ocular involvement are required, to exclude the other causes of scarring conjunctivitis, until more sensitive and specific immunopathology tests become available

Hidradenitis suppurativa:The third cause of vulva carcinoma

The development of squamous cell carcinoma (SCC) is a severe complication of chronic HS (HS). HS associated SCC can present as a painful, persistent tumour or ulcer without typical HS characteristics such as sinus formation and inflammation. Especially male patients with prolonged HS in extra-axillary areas are at risk for this complication. This case of HS associated vulvar SCC emphasizes that also women can develop this complication. In addition to lichen sclerosus vulvae (via dVIN) and high risk HPV (via uVIN) there is a third disease that can lead to vulvar cancer; chronic HS. The clinician should be vigilant for the development of malignant transformation in cases of severe, chronic HS, and should have a low threshold for biopsy. Staging, therapy and follow-up should be performed by gynecologic oncologists in an academic center.</p

The afterglows of gamma-ray bursts

Gamma-ray burst astronomy has undergone a revolution in the last three years, spurred by the discovery of fading long-wavelength counterparts. We now know that at least the long-duration GRBs lie at cosmological distances with estimated electromagnetic energy release of 10^51–10^53 erg, making these the brightest explosions in the Universe. In this article we review the current observational state, beginning with the statistics of X-ray, optical, and radio afterglow detections. We then discuss the insights these observations have given to the progenitor population, the energetics of the GRB events, and the physics of the afterglow emission. We focus particular attention on the evidence linking GRBs to the explosion of massive stars. Throughout, we identify remaining puzzles and uncertainties, and emphasize promising observational tools for addressing them. The imminent launch of HETE-2 and the increasingly sophisticated and coordinated ground-based and space-based observations have primed this field for fantastic growth

The afterglows of gamma-ray bursts

Gamma-ray burst astronomy has undergone a revolution in the last three years, spurred by the discovery of fading long-wavelength counterparts. We now know that at least the long duration GRBs lie at cosmological distances with estimated electromagnetic energy release of 10^51–10^53 erg, making these the brightest explosions in the Universe. In this article we review the current observational state, beginning with the statistics of X-ray, optical, and radio afterglow detections. We then discuss the insights these observations have given to the progenitor population, the energetics of the GRB events, and the physics of the afterglow emission. We focus particular attention on the evidence linking GRBs to the explosion of massive stars. Throughout, we identify remaining puzzles and uncertainties, and emphasize promising observational tools for addressing them. The imminent launch of HETE-2 and the increasingly sophisticated and coordinated ground-based and space-based observations have primed this field for fantastic growth. This overview is a combined write-up of talks given at this conference and in NASA's Goddard Space Flight Center

The afterglows of gamma-ray bursts

Gamma-ray burst astronomy has undergone a revolution in the last three years, spurred by the discovery of fading long-wavelength counterparts. We now know that at least the long duration GRBs lie at cosmological distances with estimated electromagnetic energy release of 10^51–10^53 erg, making these the brightest explosions in the Universe. In this article we review the current observational state, beginning with the statistics of X-ray, optical, and radio afterglow detections. We then discuss the insights these observations have given to the progenitor population, the energetics of the GRB events, and the physics of the afterglow emission. We focus particular attention on the evidence linking GRBs to the explosion of massive stars. Throughout, we identify remaining puzzles and uncertainties, and emphasize promising observational tools for addressing them. The imminent launch of HETE-2 and the increasingly sophisticated and coordinated ground-based and space-based observations have primed this field for fantastic growth

Factors influencing the surgical process during shoulder joint replacement:Time-action analysis of five different prostheses and three different approaches

Background: To evaluate the per-operative process of shoulder joint replacement, time-action analysis can be used.Material/Methods: Forty procedures performed by 7 surgeons with different experience rising 5 different prostheses and 3 different Surgical approaches were analyzed.Results: The surgical procedures showed a large variation in, for example, duration, tasks of team members, and protocol used. The surgical procedure was influenced by several factors, such as the prosthesis used, the surgical approach, the patient's condition, and the experience of the surgeon. Exposure of the glenoid was difficult and several retractors were needed, which were held by an extra assistant or clamped to the table or the surgeon. Two main limitations were seen in all procedures: repeated actions and waiting. Also, five errors could be identified. None of the alignment instruments was completely reliable and they allowed the surgeon to make major errors.Conclusions: Better alignment instruments, pre-operative planning techniques, and operation protocols are needed for shoulder prostheses. The training of resident surgeons should be focused on the exposure phase, the alignment of the humeral head, the exposure of the glenoid, and the alignment of the glenoid. Evaluating the surgical process using time-action analysis can be used to determine the limitations during surgical procedures. Furthermore, it shows the large variation in factors affecting surgical performance, indicating that a system approach is needed to improve surgical outcome.</p