28,158 research outputs found
Reionization of Hydrogen and Helium by Early Stars and Quasars
We compute the reionization histories of hydrogen and helium due to the
ionizing radiation fields produced by stars and quasars. For the quasars we use
a model based on halo-merger rates that reproduces all known properties of the
quasar luminosity function at high redshifts. The less constrained properties
of the ionizing radiation produced by stars are modeled with two free
parameters: (i) a transition redshift, z_tran, above which the stellar
population is dominated by massive, zero-metallicity stars and below which it
is dominated by a Scalo mass function; (ii) the product of the escape fraction
of stellar ionizing photons from their host galaxies and the star-formation
efficiency, f_esc f_*. We constrain the allowed range of these free parameters
at high redshifts based on the lack of the HI Gunn-Peterson trough at z<6 and
the upper limit on the total intergalactic optical depth for electron
scattering, tau_es<0.18, from recent cosmic microwave background (CMB)
experiments. We find that quasars ionize helium by a redshift z~4, but cannot
reionize hydrogen by themselves before z~6. A major fraction of the allowed
combinations of f_esc f_* and z_tran lead to an early peak in the ionized
fraction due to metal-free stars at high redshifts. This sometimes results in
two reionization epochs, namely an early HII or HeIII overlap phase followed by
recombination and a second overlap phase. Even if early overlap is not
achieved, the peak in the visibility function for scattering of the CMB often
coincides with the early ionization phase rather than with the actual
reionization epoch. Consequently, tau_es does not correspond directly to the
reionization redshift. We generically find values of tau_es>7%, that should be
detectable by the MAP satellite.Comment: 33 pages, 10 figures, Accepted for publication in Ap
Are the Earth and the Moon compositionally alike? Inferences on lunar composition and implications for lunar origin and evolution from geophysical modeling
The main objective of the present study is to discuss in detail the results obtained from an inversion of the Apollo lunar seismic data set, lunar mass, and moment of inertia. We inverted directly for lunar chemical composition and temperature using the model system CaO-FeO-MgO-Al2O3-SiO2. Using Gibbs free energy minimization, stable
mineral phases at the temperatures and pressures of interest, their modes and physical properties are calculated. We determine the compositional range of the oxide elements, thermal state, Mg#, mineralogy and physical structure of the lunar interior, as well as constraining core size and density. The results indicate a lunar mantle mineralogy that is dominated by olivine and orthopyroxene ( 80 vol%), with the remainder being composed of clinopyroxene and an aluminous phase (plagioclase, spinel, and garnet present in the depth ranges 0–150 km, 150–200 km, and >200 km, respectively). This model is broadly
consistent with constraints on mantle mineralogy derived from the experimental and
observational study of the phase lationships and trace element compositions of lunar
mare basalts and picritic glasses. In particular, by melting a typical model mantle
composition using the pMELTS algorithm, we found that a range of batch melts generated
from these models have features in common with low Ti mare basalts and picritic glasses. Our results also indicate a bulk lunar composition and Mg# different to that of the Earth’s upper mantle, represented by the pyrolite composition. This difference is reflected in a lower bulk lunar Mg# ( 0.83). Results also indicate a small iron-like core with a radius around 340 km.The Carlsberg Foundation, NER
The plastic limit of clays
The plastic limit of soils was first described by Atterberg in 1911. The thread-rolling test was standardised at the US Public Roads Bureau in the 1920s and 1930s, and has subsequently become one of the standard tests of soil mechanics. This paper reviews the original definitions of plastic limit as proposed by Atterberg, and proposes that the brittle failure observed in the plastic limit test is caused by either air entry or cavitation in the clay. Critical state soil mechanics is used to show that the observed range of undrained shear strengths of soils at plastic limit is consistent with this hypothesis. The fallacy that strength at plastic limit is a constant is highlighted, and the implications for geotechnical practice are discussed. </jats:p
A rule-based kinetic model of RNA polymerase II C-terminal domain phosphorylation
The complexity ofmany RNA processing pathways is such that a conventional systemsmodelling approach is inadequate to represent all themolecular species involved. We demonstrate that rule-based modelling permits a detailed model of a complex RNA signalling pathway to be defined. Phosphorylation of the RNApolymerase II (RNAPII)C-terminal domain (CTD; a flexible tail-like extension of the largest subunit) couples pre-messenger RNA capping, splicing and 30 end maturation to transcriptional elongation and termination, and plays a central role in integrating these processes. The phosphorylation states of the serine residues of many heptapeptide repeats of the CTD alter along the coding region of genes as a function of distance from the promoter. From a mechanistic perspective, both the changes in phosphorylation and the location atwhich they take place on the genes are a function of the time spent byRNAPII in elongation as this interval provides the opportunity for the kinases and phosphatases to interactwith theCTD.On this basis,we synthesize the available data to create a kinetic model of the action of the known kinases and phosphatases to resolve the phosphorylation pathways and their kinetics.</p
Lyophilisation of lentiviral pseudotypes for the development and distribution of virus neutralisation assay kits for rabies, Marburg and influenza viruses
Purpose: Some conventional serological assays can accurately quantify neutralising antibody responses raised against epitopes on virus glycoproteins, enabling mass vaccine evaluation and serosurveillance studies to take place. However, these assays often necessitate the handling of wild-type virus in expensive high biosafety laboratories, which restricts the scope of their application, particularly in resource-deprived areas. A solution to this issue is the use of lentiviral pseudotype viruses (PVs)—chimeric, replication-deficient virions that imitate the binding and entry mechanisms of their wild-type equivalents. Pseudotype virus neutralisation assays (PVNAs) bypass high biosafety requirements and yield comparable results to established assays. This study explores the potential for using lyophilisation of pseudotypes as a cost-effective, alternative means for production, distribution and storage of a PVNAbased diagnostic kit. Methods & Materials: Rabies, Marburg and H5 subtype Influenza virus pseudotypes were each suspended in cryoprotectant solutions of various molarities and subjected to freeze-drying before incubation at a variety of temperatures, humidities and time periods. Samples were then employed in antibody neutralisation assays using specific sera. Results: High levels of PV titre were retained post-lyophilisation, with acceptable levels of virus activity maintained even after medium-term storage in tropical conditions. Also, the performance of PVs in neutralisation assays was not affected by the lyophilisation process. Conclusion: These results confirm the viability of a freeze-dried PVNA-based diagnostic kit, which could considerably facilitate in-field serology for a number of clinically important viruses
Sonochemically fabricated microelectrode arrays for biosensors. Part II. Modification with a polysiloxane coating
A polymer modified sonochemically fabricated glucose oxidase microelectrode
array with microelectrode population densities of up to 2.5 x 105
microelectrodes cm-2 is reported. These microelectrode sensors were formed by
first depositing an insulating film on commercial screen printed electrodes
which was subsequently sonicated to form cavities of regular sizes in the film.
Electropolymerisation of aniline at the microelectrode cavities formed
polyaniline protrusions containing entrapped glucose oxidase. Chemical
deposition of polysiloxane from dichlorodimethysilane was used to deposit a thin
protective and diffusion mass transport controlling coating over the electrodes.
The physical and electrochemical properties of these films were studied. The
performance of the final glucose oxidase based microelectrode sensor array is
reported
Well-Posedness And Accuracy Of The Ensemble Kalman Filter In Discrete And Continuous Time
The ensemble Kalman filter (EnKF) is a method for combining a dynamical model
with data in a sequential fashion. Despite its widespread use, there has been
little analysis of its theoretical properties. Many of the algorithmic
innovations associated with the filter, which are required to make a useable
algorithm in practice, are derived in an ad hoc fashion. The aim of this paper
is to initiate the development of a systematic analysis of the EnKF, in
particular to do so in the small ensemble size limit. The perspective is to
view the method as a state estimator, and not as an algorithm which
approximates the true filtering distribution. The perturbed observation version
of the algorithm is studied, without and with variance inflation. Without
variance inflation well-posedness of the filter is established; with variance
inflation accuracy of the filter, with resepct to the true signal underlying
the data, is established. The algorithm is considered in discrete time, and
also for a continuous time limit arising when observations are frequent and
subject to large noise. The underlying dynamical model, and assumptions about
it, is sufficiently general to include the Lorenz '63 and '96 models, together
with the incompressible Navier-Stokes equation on a two-dimensional torus. The
analysis is limited to the case of complete observation of the signal with
additive white noise. Numerical results are presented for the Navier-Stokes
equation on a two-dimensional torus for both complete and partial observations
of the signal with additive white noise
Associations between selected demographic, biological, school environmental and physical education based correlates, and adolescent physical activity
The study investigated associations between selected physical activity correlates among 299 adolescents (90 boys, age 12-14 years) from 3 English schools. Physical activity was assessed by self-report and accelerometry. Correlates represented biological, predisposing, and demographic factors as described in the Youth Physical Activity Promotion Model. Boys engaged in more self-reported (p &lt; .01) and accelerometer assessed physical activity than girls (p = .02). Positive associations between sex (male), BMI, Perceived PE Ability, Perceived PE Worth, number of enrolled students, and physical activity outcomes were evident (p &lt; .05). Schoolbased physical activity promotion should emphasize sex-specific enhancement of students' perceived PE competence and enjoyment
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