Interatrial shunt devices for heart failure with normal ejection fraction: a technology update

Heart failure with normal ejection fraction (HeFNEF) accounts for ~50% of heart failure admissions. Its pathophysiology and diagnostic criteria are yet to be defined clearly which may hinder the search for effective treatments. The clinical hallmark of HeFNEF is exertional breathlessness, often due to an abnormal increase in left atrial pressure during exercise. Creation of an interatrial communication to offload the left atrium is a possible therapeutic approach. There are two percutaneously delivered devices currently under investigation which are discussed in this review

How the doctorate contributes to the formation of active researchers: what the research tells us

While much research focuses on factors contributing to doctoral completion, few studies explore the role of the doctorate in forming active researchers with the skills, know-how and appetite to pursue research post-completion. This article investigates 15 existing studies for evidence of what factors in the doctoral experience may contribute to the formation of an active researcher with a capacity for later research productivity. The analysis reveals a productive advisor may be key to forming an active researcher and, although inconclusive, productivity post-completion. Further detailed research is required, however, into how the advisor influences candidates' productivity. The article also points to other potentially influential factors requiring further investigation, such as: developing collaborative capacities, conceptualising the purpose of the doctorate as forming an active researcher, advisor mentoring and fostering emotional engagement with research

Up and away: ontogenic transference as a pathway for aerial dispersal of microplastics

Microplastics (MPs) are ubiquitous pollutants found in marine, freshwater and terrestrial ecosystems. With so many MPs in aquatic systems it is inevitable that they will be ingested by aquatic organisms, and be transferred up through the food chain. However, to date, no study has considered whether MPs can be transmitted by means of ontogenic transference i.e. between life stages that utilise different habitats. Here, we determine whether fluorescent polystyrene beads could transfer between Culex mosquito life stages and, particularly, could move into the flying adult stage. We show for the first time that MPs can be transferred ontogenically from a feeding (larva) into a non-feeding (pupa) life stage and subsequently into the adult terrestrial life stage. However, transference is dependent on particle size, with smaller 2 µm MPs transferring readily into pupae and adult stages, whilst 15 µm MPs transferred at a significantly reduced rate. Microplastics appear to accumulate in the Malpighian tubule renal excretion system. The transfer of MPs to the adults represents a potential aerial pathway to contamination of new environments. Thus, any organism that feeds on terrestrial life phases of freshwater insects could be impacted by MPs found in aquatic ecosystems

'These are issues that should not be raised in black and white': the culture of progress reporting and the doctorate

This paper reports findings from Australian research into student, academic and administrative staff understandings of the role and efficacy of periodic progress reports designed to monitor the progress of higher-degree-by-research candidates. Major findings are that confusion of the purpose and ultimate audience of these reports is linked to less than effective reporting by all parties; countersigning and report dependency requirements inhibit the frank reporting of progress and 'social learning' impacts on the way candidates and sometimes supervisors approach reporting obligations, running counter to institutional imperatives. We conclude that no ready or transparent nexus between the progress report and progress may be assumed. Fundamentally, this calls into question the usefulness of this process as currently implemented. Arising from this is the recommendation that progress reporting be linked to substantive reviews of progress and embedded in the pedagogy and curriculum of higher-degree-by-research programmes

The entrepreneurial subjectivity of successful researchers

This article begins the work of examining what kind of doctoral experiences positively influence researcher development, and what other attributes may contribute to a successful research career. It reports preliminary findings from the analysis of survey responses by a sample of successful mid-career researchers. Positive doctoral experiences and the early establishment of research activity are found to be important to researcher development. Successful researchers were also found to be able to acknowledge the importance of their 'soft skills', and to have flexible, responsive and adaptive dispositions. We term this disposition 'an entrepreneurial subjectivity' and argue that it is an important and underexamined characteristic of the successful researcher

Independence interrupted: creativity, context and the 'independent scholar'

Social and networked conceptions of creativity highlight the key role of collaboration and connection making in the work involved in creating and imagining new knowledge. With governments around the world keen to harness the potential of research to foster innovation and economic growth, the question arises as to whether the research degree experience is preparing graduates to be creative, or mobilise creativity, in this way. In this chapter we explore this issue through examining the persistent figure of the 'independent scholar' in accounts of research education and practice. We draw on preliminary analysis of data collected on the role of the doctorate in mid-career research success based on a survey of Australian Research Council Future Fellowship recipients. Our analysis focuses on responses to two open ended questions concerning; a) to what respondents' attribute their mid-career research sucess, and d) the extent to which the PhD experience provides preparation for a research career. We identify intriguing tensions and contradictions in the ways in which being and becoming a successful researcher are conceived. Most notably, the findings suggest that success can be achieved through different modes of working - and being trained - as a researcher. These have implications for universities seeking to promote research collaboration and creativity

An objective frequency domain method for quantifying confined aquifer compressible storage using Earth and atmospheric tides

The groundwater hydraulic head response to the worldwide and ubiquitous atmospheric tide at 2 cycles per day (cpd) is a direct function of confined aquifer compressible storage. The ratio of the responses of hydraulic head to the atmospheric pressure change is a measure of aquifer barometric efficiency, from which formation compressibility and aquifer specific storage can be determined in situ rather than resorting to laboratory or aquifer pumping tests. The Earth tide also impacts the hydraulic head response at the same frequency, and a method is developed here to quantify and remove this interference. As a result, the barometric efficiency can be routinely calculated from 6-hourly hydraulic head, atmospheric pressure, and modeled Earth tide records where available for a minimum of 15 days duration. This new approach will be of critical importance in assessing worldwide problems of land subsidence or groundwater resource evaluation that both occur due to groundwater abstractio

Strong "quantum" chaos in the global ballooning mode spectrum of three-dimensional plasmas

The spectrum of ideal magnetohydrodynamic (MHD) pressure-driven (ballooning) modes in strongly nonaxisymmetric toroidal systems is difficult to analyze numerically owing to the singular nature of ideal MHD caused by lack of an inherent scale length. In this paper, ideal MHD is regularized by using a $k$-space cutoff, making the ray tracing for the WKB ballooning formalism a chaotic Hamiltonian billiard problem. The minimum width of the toroidal Fourier spectrum needed for resolving toroidally localized ballooning modes with a global eigenvalue code is estimated from the Weyl formula. This phase-space-volume estimation method is applied to two stellarator cases.Comment: 4 pages typeset, including 2 figures. Paper accepted for publication in Phys. Rev. Letter

Optical Detection of a Single Nuclear Spin

We propose a method to optically detect the spin state of a 31-P nucleus embedded in a 28-Si matrix. The nuclear-electron hyperfine splitting of the 31-P neutral-donor ground state can be resolved via a direct frequency discrimination measurement of the 31-P bound exciton photoluminescence using single photon detectors. The measurement time is expected to be shorter than the lifetime of the nuclear spin at 4 K and 10 T.Comment: 4 pages, 3 figure