6,315 research outputs found
Modelling crystal aggregation and deposition\ud in the catheterised lower urinary tract
Urethral catheters often become encrusted with crystals of magnesium struvite and calcium phosphate. The encrustation can block the catheter, which can cause urine retention in the bladder and reflux into the kidneys. We develop a mathematical model to investigate crystal deposition on the catheter surface, modelling the bladder as a reservoir of fluid and the urethral catheter as a rigid channel. At a constant rate, fluid containing crystal particles of unit size enters the reservoir, and flows from the reservoir through the channel and out of the system. The crystal particles aggregate, which we model using Becker–Döring coagulation theory, and are advected through the channel, where they continue to aggregate and are deposited on the channel’s walls. Inhibitor particles also enter the reservoir, and can bind to the crystals, preventing further aggregation and deposition. The crystal concentrations are spatially homogeneous in the reservoir, whereas the channel concentrations vary spatially as a result of advection, diffusion and deposition. We investigate the effect of inhibitor particles on the amount of deposition. For all parameter values, we find that crystals deposit along the full length of the channel, with maximum deposition close to the channel’s entrance
Loading Bose condensed atoms into the ground state of an optical lattice
We optimize the turning on of a one-dimensional optical potential, V_L(x,t) =
S(t) V_0 cos^2(kx) to obtain the optimal turn-on function S(t) so as to load a
Bose-Einstein condensate into the ground state of the optical lattice of depth
V_0. Specifically, we minimize interband excitations at the end of the turn-on
of the optical potential at the final ramp time t_r, where S(t_r) = 1, given
that S(0) = 0. Detailed numerical calculations confirm that a simple unit cell
model is an excellent approximation when the turn-on time t_r is long compared
with the inverse of the band excitation frequency and short in comparison with
nonlinear time \hbar/\mu where \mu is the chemical potential of the condensate.
We demonstrate using the Gross-Pitaevskii equation with an optimal turn-on
function S(t) that the ground state of the optical lattice can be loaded with
very little excitation even for times t_r on the order of the inverse band
excitation frequency
The Statistics of the BATSE Spectral Features
The absence of a BATSE line detection in a gamma-ray burst spectrum during
the mission's first six years has led to a statistical analysis of the
occurrence of lines in the BATSE burst database; this statistical analysis will
still be relevant if lines are detected. We review our methodology, and present
new simulations of line detectability as a function of the line parameters. We
also discuss the calculation of the number of ``trials'' in the BATSE database,
which is necessary for our line detection criteria.Comment: 5 pages, 2 figures, AIPPROC LaTeX, to appear in "Gamma-Ray Bursts,
4th Huntsville Symposium," eds. C. Meegan, R. Preece and T. Koshu
Target Mass Monitoring and Instrumentation in the Daya Bay Antineutrino Detectors
The Daya Bay experiment measures sin^2 2{\theta}_13 using functionally
identical antineutrino detectors located at distances of 300 to 2000 meters
from the Daya Bay nuclear power complex. Each detector consists of three nested
fluid volumes surrounded by photomultiplier tubes. These volumes are coupled to
overflow tanks on top of the detector to allow for thermal expansion of the
liquid. Antineutrinos are detected through the inverse beta decay reaction on
the proton-rich scintillator target. A precise and continuous measurement of
the detector's central target mass is achieved by monitoring the the fluid
level in the overflow tanks with cameras and ultrasonic and capacitive sensors.
In addition, the monitoring system records detector temperature and levelness
at multiple positions. This monitoring information allows the precise
determination of the detectors' effective number of target protons during data
taking. We present the design, calibration, installation and in-situ tests of
the Daya Bay real-time antineutrino detector monitoring sensors and readout
electronics.Comment: 22 pages, 20 figures; accepted by JINST. Changes in v2: minor
revisions to incorporate editorial feedback from JINS
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Evidence for clonal selection of gamma/delta T cells in response to a human pathogen.
T cells bearing gamma/delta antigen receptors comprise a resident population of intraepithelial lymphocytes in organs such as skin, gut, and lungs, where they are strategically located to contribute to the initial defense against infection. An important unsolved question about antigen-driven gamma/delta T cell responses regards the breadth of their T cell receptor (TCR) repertoire, since many specific epithelial compartments in mice display limited diversity. We have examined the diversity of TCR delta gene expression among human gamma/delta T cells from skin lesions induced by intradermal challenge with Mycobacterium leprae. We show that the vast majority of gamma/delta cells from M. leprae lesions use either V delta 1-J delta 1 or V delta 2-J delta 1 gene rearrangements and, within a given region of the lesion, display limited junctional diversity. This contrasts markedly with the extensive diversity of gamma/delta T cells from peripheral blood of these same individuals, as well as skin from normal donors. These results indicate that the gamma/delta response to M. leprae involves the selection of a limited number of clones from among a diverse repertoire, probably in response to specific mycobacterial and/or host antigens
Influence of the Earth on the background and the sensitivity of the GRM and ECLAIRs instruments aboard the Chinese-French mission SVOM
SVOM (Space-based multi-band astronomical Variable Object Monitor) is a
future Chinese-French satellite mission which is dedicated to Gamma-Ray Burst
(GRB) studies. Its anti-solar pointing strategy makes the Earth cross the field
of view of its payload every orbit. In this paper, we present the variations of
the gamma-ray background of the two high energy instruments aboard SVOM, the
Gamma-Ray Monitor (GRM) and ECLAIRs, as a function of the Earth position. We
conclude with an estimate of the Earth influence on their sensitivity and their
GRB detection capability.Comment: 24 pages, 15 figures, accepted for publication in Experimental
Astronom
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