458 research outputs found
Ranking the importance of nuclear reactions for activation and transmutation events
Pathways-reduced analysis is one of the techniques used by the Fispact-II
nuclear activation and transmutation software to study the sensitivity of the
computed inventories to uncertainties in reaction cross-sections. Although
deciding which pathways are most important is very helpful in for example
determining which nuclear data would benefit from further refinement,
pathways-reduced analysis need not necessarily define the most critical
reaction, since one reaction may contribute to several different pathways. This
work examines three different techniques for ranking reactions in their order
of importance in determining the final inventory, comparing the pathways based
metric (PBM), the direct method and one based on the Pearson correlation
coefficient. Reasons why the PBM is to be preferred are presented.Comment: 30 pages, 10 figure
Wavenumber Selection of Convection Rolls in a Box
The dynamics of two‐dimensional Rayleigh–Bénard convection rolls are studied in a finite layer with no‐slip, fixed temperature upper and lower boundaries and no‐slip insulating side walls. The dominant mechanism controlling the number of rolls seen in the layer is an instability concentrated near the side walls. This mechanism significantly narrows the band of stable wavenumbers although it can take a time comparable to the long (horizontal) diffusion time scale to operate
Adsorptive graphene doping: Effect of a polymer contaminant
© 2017 Author(s). Transfer-induced contamination of graphene and the limited stability of adsorptive dopants are two of the main issues faced in the practical realization of graphene-based electronics. Herein, we assess the stability of HNO3, MoO3, and AuCl3 dopants upon transferred graphene with different extents of polymer contamination. Sheet resistivity measurements prove that polymer residues induce a significantly degenerative effect in terms of doping stability for HNO3 and MoO3 and a highly stabilizing effect for AuCl3. Further characterization by Raman spectroscopy and atomic force microscopy (AFM) provides insight into the stability mechanism. Together, these findings demonstrate the relevance of contamination in the field of adsorptive doping for the realization of graphene-based functional devices
OT 060420: A Seemingly Optical Transient Recorded by All-Sky Cameras
We report on a ~5th magnitude flash detected for approximately 10 minutes by
two CONCAM all-sky cameras located in Cerro Pachon - Chile and La Palma -
Spain. A third all-sky camera, located in Cerro Paranal - Chile did not detect
the flash, and therefore the authors of this paper suggest that the flash was a
series of cosmic-ray hits, meteors, or satellite glints. Another proposed
hypothesis is that the flash was an astronomical transient with variable
luminosity. In this paper we discuss bright optical transient detection using
fish-eye all-sky monitors, analyze the apparently false-positive optical
transient, and propose possible causes to false optical transient detection in
all-sky cameras.Comment: 7 figures, 3 tables, accepted PAS
van der Waals density functionals built upon the electron-gas tradition: Facing the challenge of competing interactions
The theoretical description of sparse matter attracts much interest, in
particular for those ground-state properties that can be described by density
functional theory (DFT). One proposed approach, the van der Waals density
functional (vdW-DF) method, rests on strong physical foundations and offers
simple yet accurate and robust functionals. A very recent functional within
this method called vdW-DF-cx [K. Berland and P. Hyldgaard, Phys. Rev. B 89,
035412] stands out in its attempt to use an exchange energy derived from the
same plasmon-based theory from which the nonlocal correlation energy was
derived. Encouraged by its good performance for solids, layered materials, and
aromatic molecules, we apply it to several systems that are characterized by
competing interactions. These include the ferroelectric response in PbTiO,
the adsorption of small molecules within metal-organic frameworks (MOFs), the
graphite/diamond phase transition, and the adsorption of an aromatic-molecule
on the Ag(111) surface. Our results indicate that vdW-DF-cx is overall well
suited to tackle these challenging systems. In addition to being a competitive
density functional for sparse matter, the vdW-DF-cx construction presents a
more robust general purpose functional that could be applied to a range of
materials problems with a variety of competing interactions
Lecturers’ perceptions: the value of assessment rubrics for informing teaching practice and curriculum review and development
http://dx.doi.org/10.1080/18146627.2015.1110907The assessment rubric is increasingly gaining recognition as a valuable tool in teaching and learning in higher education. While many studies have examined the value of rubrics for students, research into the lecturers’ usage of rubrics is limited. This article explores the lecturers’ perceptions of rubrics, in particular, its use and design, the role it can play in informing one's teaching practice and in curriculum review and development. The data shows that many lecturers use the rubric in a very mechanical and unconscious manner and view it mostly as a grading tool with limited instructional value. While acknowledging the rubric as a reflective tool for students, lecturers do not perceive it as having the same benefits for them. The findings, therefore suggest more conversations around the role that rubrics can play in informing one's teaching practice and course design. It also suggests further research into this area.Web of Scienc
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Microfluidic approaches for the analysis of protein–protein interactions in solution
Abstract: Exploration and characterisation of the human proteome is a key objective enabling a heightened understanding of biological function, malfunction and pharmaceutical design. Since proteins typically exhibit their behaviour by binding to other proteins, the challenge of probing protein-protein interactions has been the focus of new and improved experimental approaches. Here, we review recently developed microfluidic techniques for the study and quantification of protein–protein interactions. We focus on methodologies that utilise the inherent strength of microfluidics for the control of mass transport on the micron scale, to facilitate surface and membrane-free interrogation and quantification of interacting proteins. Thus, the microfluidic tools described here provide the capability to yield insights on protein–protein interactions under physiological conditions. We first discuss the defining principles of microfluidics, and methods for the analysis of protein–protein interactions that utilise the diffusion-controlled mixing characteristic of fluids at the microscale. We then describe techniques that employ electrophoretic forces to manipulate and fractionate interacting protein systems for their biophysical characterisation, before discussing strategies that use microdroplet compartmentalisation for the analysis of protein interactions. We conclude by highlighting future directions for the field, such as the integration of microfluidic experiments into high-throughput workflows for the investigation of protein interaction networks
Recommended from our members
Microfluidic approaches for the analysis of protein–protein interactions in solution
Abstract: Exploration and characterisation of the human proteome is a key objective enabling a heightened understanding of biological function, malfunction and pharmaceutical design. Since proteins typically exhibit their behaviour by binding to other proteins, the challenge of probing protein-protein interactions has been the focus of new and improved experimental approaches. Here, we review recently developed microfluidic techniques for the study and quantification of protein–protein interactions. We focus on methodologies that utilise the inherent strength of microfluidics for the control of mass transport on the micron scale, to facilitate surface and membrane-free interrogation and quantification of interacting proteins. Thus, the microfluidic tools described here provide the capability to yield insights on protein–protein interactions under physiological conditions. We first discuss the defining principles of microfluidics, and methods for the analysis of protein–protein interactions that utilise the diffusion-controlled mixing characteristic of fluids at the microscale. We then describe techniques that employ electrophoretic forces to manipulate and fractionate interacting protein systems for their biophysical characterisation, before discussing strategies that use microdroplet compartmentalisation for the analysis of protein interactions. We conclude by highlighting future directions for the field, such as the integration of microfluidic experiments into high-throughput workflows for the investigation of protein interaction networks
Is Scotland a Westminster-style Majoritarian Democracy or a Scandinavian-style Consensus Democracy? A Comparison of Scotland, the UK and Sweden
Peer reviewedPostprin
Boundary Limitation of Wavenumbers in Taylor-Vortex Flow
We report experimental results for a boundary-mediated wavenumber-adjustment
mechanism and for a boundary-limited wavenumber-band of Taylor-vortex flow
(TVF). The system consists of fluid contained between two concentric cylinders
with the inner one rotating at an angular frequency . As observed
previously, the Eckhaus instability (a bulk instability) is observed and limits
the stable wavenumber band when the system is terminated axially by two rigid,
non-rotating plates. The band width is then of order at small
() and agrees well with
calculations based on the equations of motion over a wide -range.
When the cylinder axis is vertical and the upper liquid surface is free (i.e.
an air-liquid interface), vortices can be generated or expelled at the free
surface because there the phase of the structure is only weakly pinned. The
band of wavenumbers over which Taylor-vortex flow exists is then more narrow
than the stable band limited by the Eckhaus instability. At small
the boundary-mediated band-width is linear in . These results are
qualitatively consistent with theoretical predictions, but to our knowledge a
quantitative calculation for TVF with a free surface does not exist.Comment: 8 pages incl. 9 eps figures bitmap version of Fig
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