3,594 research outputs found
Estimation of a preference based single index from the sexual quality of life questionnaire (SQOL) using ordinal data
There is increasing interest in using ordinal methods to estimate cardinal values for health states to calculate quality adjusted life years. This paper reports the estimation of models of rank data and discrete choice experiment (DCE) data to derive a preference-based index from a condition specific measure relating to sexual health and to compare the results to values generated from time trade-off valuation (TTO). The DCE data were analysed using a random effects probit model and the DCE predicted values were rescaled according to the highest and lowest predicted TTO values corresponding to the best and worst SQOL health states respectively. The rank data were analysed using a rank ordered logit model and re-scaled using two alternative methods. Firstly, re-scaling the rank predicted values using identical methods to those employed for DCE and secondly, re-scaling the rank model coefficients by dividing each level coefficient by the coefficient relating to death. The study raises some important issues about the use of ordinal data to produce cardinal health state valuations
Estimation of a preference based single index from the sexual quality of life questionnaire (SQOL) using ordinal data
There is increasing interest in using ordinal methods to estimate cardinal values for health states to calculate quality adjusted life years. This paper reports the estimation of models of rank data and discrete choice experiment (DCE) data to derive a preference-based index from a condition specific measure relating to sexual health and to compare the results to values generated from time trade-off valuation (TTO). The DCE data were analysed using a random effects probit model and the DCE predicted values were rescaled according to the highest and lowest predicted TTO values corresponding to the best and worst SQOL health states respectively. The rank data were analysed using a rank ordered logit model and re-scaled using two alternative methods. Firstly, re-scaling the rank predicted values using identical methods to those employed for DCE and secondly, re-scaling the rank model coefficients by dividing each level coefficient by the coefficient relating to death. The study raises some important issues about the use of ordinal data to produce cardinal health state valuations.sexual health, quality of life, preference-based measures
Estimation of a preference based single index from the sexual quality of life questionnaire (SQOL) using ordinal data
There is increasing interest in using ordinal methods to estimate cardinal values for health states to calculate quality adjusted life years. This paper reports the estimation of models of rank data and discrete choice experiment (DCE) data to derive a preference-based index from a condition specific measure relating to sexual health and to compare the results to values generated from time trade-off valuation (TTO). The DCE data were analysed using a random effects probit model and the DCE predicted values were rescaled according to the highest and lowest predicted TTO values corresponding to the best and worst SQOL health states respectively. The rank data were analysed using a rank ordered logit model and re-scaled using two alternative methods. Firstly, re-scaling the rank predicted values using identical methods to those employed for DCE and secondly, re-scaling the rank model coefficients by dividing each level coefficient by the coefficient relating to death. The study raises some important issues about the use of ordinal data to produce cardinal health state valuations
Determination of the Kobayashi-Maskawa-Cabibbo matrix element V_{us} under various flavor-symmetry-breaking models in hyperon semileptonic decays
We study the success to describe hyperon semileptonic decays of four models
that incorporate second-order SU(3) symmetry breaking corrections. The criteria
to assess their success is by determining V_{us} in each of the three relevant
hyperon semileptonic decays and comparing the values obtained with one another
and also with the one that comes from K_{l3} decays. A strong dependence on the
particular symmetry breaking model is observed. Values of V_{us} which do not
agree with the one of K_{l3} are generally obtained. However, in the context of
chiral perturbation theory, only the model whose corrections are O(m_s) and
O(m_s^{3/2}) is successful. Using its predictions for the f_1 form factors one
can quote a value of V_{us} from this model, namely, V_{us}=0.2176\pm 0.0026,
which is in excellent agreement with the K_{l3} one.Comment: Final versio
Cosmological redshift distortion: deceleration, bias and density parameters from future redshift surveys of galaxies
The observed two-point correlation functions of galaxies in redshift space
become anisotropic due to the geometry of the universe as well as due to the
presence of the peculiar velocity field. On the basis of linear perturbation
theory, we expand the induced anisotropies of the correlation functions with
respect to the redshift , and obtain analytic formulae to infer the
deceleration parameter , the density parameter and the
derivative of the bias parameter at in terms of the
observable statistical quantities. The present method does not require any
assumption of the shape and amplitude of the underlying fluctuation spectrum,
and thus can be applied to future redshift surveys of galaxies including the
Sloan Digital Sky Survey. We also evaluate quantitatively the systematic error
in estimating the value of from a galaxy
redshift survey on the basis of a conventional estimator for which
neglects both the geometrical distortion effect and the time evolution of the
parameter . If the magnitude limit of the survey is as faint as 18.5
(in B-band) as in the case of the Sloan Digital Sky Survey, the systematic
error ranges between -20% and 10% depending on the cosmological parameters.
Although such systematic errors are smaller than the statistical errors in the
current surveys, they will dominate the expected statistical error for future
surveys.Comment: 9 pages, 5 figs, aastex, ApJ in press, replaced version includes
minor correction
Between-Year Survival and Rank Transitions in Male Black-Capped Chickadees (\u3cem\u3ePoecile Atricapillus\u3c/em\u3e): A Multistate Modeling Approach
In dominance-structured animal societies, variation in individual fitness is often related to social status. Like many passerine birds, Black-capped Chickadees (Poecile atricapillus) have a short average adult life-expectancy (Ă2 years); however, the maximum recorded life span is \u3e5Ă as long. Enhanced annual survival could contribute to greater lifetime reproductive success for male Black-capped Chickadees with high social rank. We used multistate captureâmarkârecapture models to estimate annual survival of male Black-capped Chickadees in Ontario using resighting and recapture data collected from 1997 to 2002. Our goal was to evaluate support for an influence of rank on annual survival and estimate its effect size for a food-supplemented study site. We also statistically modeled the probability of between-year rank transitions. Model selection based on Akaikeâs information criterion provided support for an effect of rank on survival. However, multimodel inference revealed that the size of the effect was rather small. Over the six study years, model-averaged estimates of the survival benefit of high versus low rank ranged from 5.0 to 7.3%. As expected, survival was strongly year-dependent, with model-averaged estimates of annual survival probability varying between 0.36 and 0.73. Age was an important predictor of the probability of rank transitions. Low-ranked second-year birds were less likely than older low-ranked birds to advance to high rank between years; likewise, high-ranked after-second-year birds were less likely to drop in rank. Other studies have found larger effects of rank on survival than we observed here. Future research should consider how interactions between social and environmental factors influence annual survival
Pattern of physical activity can influence its efficacy on muscle and bone health in middle-aged men and women
Purpose This study aimed at investigating whether association between physical activity, and bone density and muscle strength depends on daily activity pattern.Methods Loading dose of moderate-to-vigorous physical activity (MVPA) was measured using accelerometer on 54 men (Mage = 54.1Â years) and 59 women (Mage = 52.1Â years). Pattern of MVPA was quantiied as number and length of MVPA bouts, and the length of break bouts between MVPA bouts. Knee extension torque (KET) and broadband ultrasound attenu-ation (BUA) of the calcaneus were also measured. Regression analysis was employed to examine the moderation efect of MVPA pattern.Results Loading dose had a larger efect on BUA (b = .002, p = .035) and KET (b = .004, p = .01) with the increase of median length of MVPA bout, but had a smaller efect on KET with the increase of maximal length of break bout (b = â .015, p = .024).Conclusions This study suggests that pattern of physical activity can inluence its eicacy on muscle and bone health
Peaks in the Hartle-Hawking Wave Function from Sums over Topologies
Recent developments in ``Einstein Dehn filling'' allow the construction of
infinitely many Einstein manifolds that have different topologies but are
geometrically close to each other. Using these results, we show that for many
spatial topologies, the Hartle-Hawking wave function for a spacetime with a
negative cosmological constant develops sharp peaks at certain calculable
geometries. The peaks we find are all centered on spatial metrics of constant
negative curvature, suggesting a new mechanism for obtaining local homogeneity
in quantum cosmology.Comment: 16 pages,LaTeX, no figures; v2: some changes coming from revision of
a math reference: wave function peaks sharp but not infinite; v3: added
paragraph in intro on interpretation of wave functio
Increased plasma viscosity as a reason for inappropriate erythropoietin formation
The aim of this study was to examine whether altered plasma viscosity could contribute to the inappropriately low production rate of erythropoietin (EPO) observed in patients suffering from hypergammaglobulinemias associated with multiple myeloma or Waldenström's disease. We found that the EPO formation in response to anemia in these patients was inversely related to plasma viscosity. A similar inverse relationship between plasma viscosity and EPO production was seen in rats in which EPO formation had been stimulated by exchange transfusion and the plasma viscosity of which was thereby altered by using exchange solutions of different composition to alter plasma viscosity and thus whole blood viscosity independently from hematocrit. Raising the gammaglobulin concentration to approximately 40 mg/ml plasma in the rats almost totally blunted the rise in serum EPO levels despite a fall of the hematocrit to 20%. Determination of renal EPO mRNA levels by RNase protection revealed that the reductions in serum EPO levels at higher plasma viscosities were paralleled by reductions in renal EPO mRNA levels. Taken together, our findings suggest that plasma viscosity may be a significant inhibitory modulator of anemia-induced EPO formation. The increased plasma viscosity in patients with hypergammaglobulinemias may therefore contribute to the inappropriate EPO production, which is a major reason for the anemia developing in these patients
Spacelike surfaces with free boundary in the Lorentz-Minkowski space
We investigate a variational problem in the Lorentz-Minkowski space \l^3
whose critical points are spacelike surfaces with constant mean curvature and
making constant contact angle with a given support surface along its common
boundary. We show that if the support surface is a pseudosphere, then the
surface is a planar disc or a hyperbolic cap. We also study the problem of
spacelike hypersurfaces with free boundary in the higher dimensional
Lorentz-Minkowski space \l^{n+1}.Comment: 16 pages. Accepted in Classical and Quantum Gravit
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