559 research outputs found
Braid Topologies for Quantum Computation
In topological quantum computation, quantum information is stored in states
which are intrinsically protected from decoherence, and quantum gates are
carried out by dragging particle-like excitations (quasiparticles) around one
another in two space dimensions. The resulting quasiparticle trajectories
define world-lines in three dimensional space-time, and the corresponding
quantum gates depend only on the topology of the braids formed by these
world-lines. We show how to find braids that yield a universal set of quantum
gates for qubits encoded using a specific kind of quasiparticle which is
particularly promising for experimental realization.Comment: 4 pages, 4 figures, minor revision
Antenna-coupled TES bolometer arrays for CMB polarimetry
We describe the design and performance of polarization selective
antenna-coupled TES arrays that will be used in several upcoming Cosmic
Microwave Background (CMB) experiments: SPIDER, BICEP-2/SPUD. The fully
lithographic polarimeter arrays utilize planar phased-antennas for collimation
(F/4 beam) and microstrip filters for band definition (25% bandwidth). These
devices demonstrate high optical efficiency, excellent beam shapes, and
well-defined spectral bands. The dual-polarization antennas provide
well-matched beams and low cross polarization response, both important for
high-fidelity polarization measurements. These devices have so far been
developed for the 100 GHz and 150 GHz bands, two premier millimeter-wave
atmospheric windows for CMB observations. In the near future, the flexible
microstrip-coupled architecture can provide photon noise-limited detection for
the entire frequency range of the CMBPOL mission. This paper is a summary of
the progress we have made since the 2006 SPIE meeting in Orlando, FL
Antenna-coupled TES bolometer arrays for CMB polarimetry
We describe the design and performance of polarization selective
antenna-coupled TES arrays that will be used in several upcoming Cosmic
Microwave Background (CMB) experiments: SPIDER, BICEP-2/SPUD. The fully
lithographic polarimeter arrays utilize planar phased-antennas for collimation
(F/4 beam) and microstrip filters for band definition (25% bandwidth). These
devices demonstrate high optical efficiency, excellent beam shapes, and
well-defined spectral bands. The dual-polarization antennas provide
well-matched beams and low cross polarization response, both important for
high-fidelity polarization measurements. These devices have so far been
developed for the 100 GHz and 150 GHz bands, two premier millimeter-wave
atmospheric windows for CMB observations. In the near future, the flexible
microstrip-coupled architecture can provide photon noise-limited detection for
the entire frequency range of the CMBPOL mission. This paper is a summary of
the progress we have made since the 2006 SPIE meeting in Orlando, FL
Topological quantum memory
We analyze surface codes, the topological quantum error-correcting codes
introduced by Kitaev. In these codes, qubits are arranged in a two-dimensional
array on a surface of nontrivial topology, and encoded quantum operations are
associated with nontrivial homology cycles of the surface. We formulate
protocols for error recovery, and study the efficacy of these protocols. An
order-disorder phase transition occurs in this system at a nonzero critical
value of the error rate; if the error rate is below the critical value (the
accuracy threshold), encoded information can be protected arbitrarily well in
the limit of a large code block. This phase transition can be accurately
modeled by a three-dimensional Z_2 lattice gauge theory with quenched disorder.
We estimate the accuracy threshold, assuming that all quantum gates are local,
that qubits can be measured rapidly, and that polynomial-size classical
computations can be executed instantaneously. We also devise a robust recovery
procedure that does not require measurement or fast classical processing;
however for this procedure the quantum gates are local only if the qubits are
arranged in four or more spatial dimensions. We discuss procedures for
encoding, measurement, and performing fault-tolerant universal quantum
computation with surface codes, and argue that these codes provide a promising
framework for quantum computing architectures.Comment: 39 pages, 21 figures, REVTe
Depression, ART Adherence, and Receipt of Case Management Services by Adults with HIV in North Carolina, Medical Monitoring Project, 2009–2013
Depression among persons with HIV is associated with antiretroviral therapy (ART) interruption and discontinuation, virological failure, and poor clinical and survival outcomes. Case management services can address needs for emotional counseling and other supportive services to facilitate HIV care engagement. Using 2009–2013 North Carolina Medical Monitoring Project data from 910 persons engaged in HIV care, we estimated associations of case management utilization with “probable current depression” and with 100% ART dose adherence. After weighting, 53.2% of patients reported receiving case management, 21.7% reported depression, and 87.0% reported ART adherence. Depression prevalence was higher among those reporting case management (24.9%) than among other patients (17.6%) (p < 0.01). Case management was associated with depression among patients living above the poverty level [adjusted prevalence ratio (aPR), 2.05; 95% confidence interval (CI) 1.25–3.36], and not among other patients (aPR, 1.01; 95% CI 0.72–1.43). Receipt of case management was not associated with ART adherence (aPR, 1.00; 95% CI 0.95–1.05). Our analysis indicates a need for more effective depression treatment, even among persons receiving case management services. Self-reported ART adherence was high overall, though lower among persons experiencing depression (unadjusted prevalence ratio, 0.92; 95% CI 0.86–0.99). Optimal HIV clinical and prevention outcomes require addressing psychological wellbeing, monitoring of ART adherence, and effective case management services
BICEP3: a 95 GHz refracting telescope for degree-scale CMB polarization
BICEP3 is a 550 mm-aperture refracting telescope for polarimetry of radiation
in the cosmic microwave background at 95 GHz. It adopts the methodology of
BICEP1, BICEP2 and the Keck Array experiments - it possesses sufficient
resolution to search for signatures of the inflation-induced cosmic
gravitational-wave background while utilizing a compact design for ease of
construction and to facilitate the characterization and mitigation of
systematics. However, BICEP3 represents a significant breakthrough in
per-receiver sensitivity, with a focal plane area 5 larger than a
BICEP2/Keck Array receiver and faster optics ( vs. ).
Large-aperture infrared-reflective metal-mesh filters and infrared-absorptive
cold alumina filters and lenses were developed and implemented for its optics.
The camera consists of 1280 dual-polarization pixels; each is a pair of
orthogonal antenna arrays coupled to transition-edge sensor bolometers and read
out by multiplexed SQUIDs. Upon deployment at the South Pole during the 2014-15
season, BICEP3 will have survey speed comparable to Keck Array 150 GHz (2013),
and will significantly enhance spectral separation of primordial B-mode power
from that of possible galactic dust contamination in the BICEP2 observation
patch.Comment: 12 pages, 5 figures. Presented at SPIE Astronomical Telescopes and
Instrumentation 2014: Millimeter, Submillimeter, and Far-Infrared Detectors
and Instrumentation for Astronomy VII. To be published in Proceedings of SPIE
Volume 915
The BICEP2 CMB polarization experiment
The Bicep2 telescope is designed to measure the polarization of the cosmic microwave background on angular scales near 2-4 degrees, near the expected peak of the B-mode polarization signal induced by primordial gravitational waves from inflation. Bicep2 follows the success of Bicep, which has set the most sensitive current limits on B-modes on 2-4 degree scales. The experiment adopts a new detector design in which beam-defining slot antennas are coupled to TES detectors photolithographically patterned in the same silicon wafer, with multiplexing SQUID readout. Bicep2 takes advantage of this design's higher focal-plane packing density, ease of fabrication, and multiplexing readout to field more detectors than Bicep1, improving mapping speed by nearly a factor of 10. Bicep2 was deployed to the South Pole in November 2009 with 500 polarization-sensitive detectors at 150 GHz, and is funded for two seasons of observation. The first months' data demonstrate the performance of the Caltech/JPL antenna-coupled TES arrays, and two years of observation with Bicep2 will achieve unprecedented sensitivity to B-modes on degree angular scales
Change in glomerular filtration rate over time in the Oxford Renal Cohort Study:observational study
Background: Decline in kidney function can result in adverse health outcomes. The Oxford Renal Cohort Study has detailed baseline assessments from 884 participants ≥60 years of age. Aim: To determine the proportion of participants with a decline in estimated glomerular filtration rate (eGFR), identify determinants of decline, and determine proportions with chronic kidney disease (CKD) remission. Design and setting: Observational cohort study in UK primary care. Method: Data were used from baseline and annual follow-up assessments to monitor change in kidney function. Rapid eGFR decline was defined as eGFR decrease >5 ml/min/1.73 m2/year, improvement as eGFR increase >5 ml/min/1.73 m2/year, and remission in those with CKD at baseline and eGFR >60 ml/min/1.73 m2 during follow-up. Cox proportional hazard models were used to identify factors associated with eGFR decline. Results: There was a net decline in eGFR in the 884 participants over 5 years of follow-up. In 686 participants with >2 eGFR tests with a median follow-up of 2.1 years, 164 (24%) evidenced rapid GFR decline, 185 (27%) experienced eGFR improvement, and 82 of 394 (21%) meeting CKD stage 1-4 at baseline experienced remission. In the multivariable analysis, smoking status, higher systolic blood pressure, and being known to have CKD at cohort entry were associated with rapid GFR decline. Those with CKD stage 3 at baseline were less likely to exhibit GFR decline compared with normal kidney function. Conclusion: This study established that 24% of people evidenced rapid GFR decline whereas 21% evidenced remission of CKD. People at risk of rapid GFR decline may benefit from closer monitoring and appropriate treatment to minimise risks of adverse outcomes, although only a small proportion meet the National Institute for Health and Care Excellence criteria for referral to secondary care.</p
Measuring vertebrate telomeres: applications and limitations
Telomeres are short tandem repeated sequences of DNA found at the ends of eukaryotic
chromosomes that function in stabilizing chromosomal end integrity.
In vivo
studies of
somatic tissue of mammals and birds have shown a correlation between telomere length and
organismal age within species, and correlations between telomere shortening rate and
lifespan among species. This result presents the tantalizing possibility that telomere length
could be used to provide much needed information on age, ageing and survival in natural
populations where longitudinal studies are lacking. Here we review methods available for
measuring telomere length and discuss the potential uses and limitations of telomeres as
age and ageing estimators in the fields of vertebrate ecology, evolution and conservation
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