Use of mathematical derivatives (time-domain differentiation) on chromatographic data to enhance the detection and quantification of an unknown 'rider' peak

Two samples of an anticancer prodrug, AQ4N, were submitted for HPLC assay and showed an unidentified impurity that eluted as a 'rider' on the tail of the main peak. Mathematical derivatization of the chromatograms offered several advantages over conventional skimmed integration. A combination of the second derivative amplitude and simple linear regression gave a novel method for estimating the true peak area of the impurity peak. All the calculation steps were carried out using a widely available spreadsheet program. (C) 2003 Elsevier B.V. All rights reserved

Treatment of dogs with compensated myxomatous mitral valve disease with spironolactone-a pilot study

Spironolactone improves outcome in dogs with advanced myxomatous mitral valve disease (MMVD). Its efficacy in preclinical MMVD is unknown. The hypothesis was the administration of spironolactone to dogs with compensated MMVD demonstrating risk factors for poorer prognosis will decrease the rate of disease progression. The aim was to provide pilot data to evaluate preliminary effects and sample size calculation for a definitive clinical trial

Study of low gravity propellant transfer Quarterly progress report, 23 Dec. 1970 - 30 Apr. 1971

Bellows, metallic diaphragm, and paddle vortex subcritical transfer systems designs and high pressure systems analyses for orbital space station cryogen

Classification of states of single-jj fermions with JJ-pairing interaction

In this paper we show that a system of three fermions is exactly solvable for the case of a single-$j$ in the presence of an angular momentum-$J$ pairing interaction. On the basis of the solutions for this system, we obtain new sum rules for six-$j$ symbols. It is also found that the "non-integer" eigenvalues of three fermions with angular momentum $I$ around the maximum appear as "non-integer" eigenvalues of four fermions when $I$ is around (or larger than) $J_{\rm max}$ and the Hamiltonian contains only an interaction between pairs of fermions coupled to spin $J=J_{\rm max}=2j-1$. This pattern is also found in five and six fermion systems. A boson system with spin $l$ exhibits a similar pattern.Comment: to be published in Physical Review

Anomalous minimum in the shear viscosity of a Fermi gas

We measure the static shear viscosity $\eta$ in a two-component Fermi gas near a broad collisional (Feshbach) resonance, as a function of interaction strength and energy. We find that $\eta$ has both a quadratic and a linear dependence on the interaction strength $1/({k_{FI}a})$, where $a$ is the s-wave scattering length and $k_{FI}$ is the Fermi wave vector for an ideal gas at the trap center. For energies above the superfluid transition, the minimum in $\eta$ as a function of interaction strength is significantly shifted toward the BEC side of resonance, to $1/(k_{FI}a)\simeq 0.25$.Comment: 14 pages, 8 figure