Cross sections of muscle fibers of (A) one FSHD patient and (B) one healthy control (20×magnification, H&E-stained).

<p>Myofiber diameter size difference indicates hypertrophy in the <i>Vastus lateralis</i> muscle of the patient.</p

Cyclin A1 expression levels in FSHD and other myopathies (microarrays).

<p><i>CCNA1</i> Human Exon 1.0 ST Array signal levels in FSHD (n = 4), healthy controls (n = 7), CAV3 (n = 4), DYSF (n = 4) and FHL1 (n = 3).</p

Distribution patterns of myofiber diameters derived from FSHD patients (n = 5) and age-matched healthy controls (n = 5).

<p>Diameters (µm) from 1000 myofibers each were measured in H&E-stained cross sections under a light microscope by using the Image J software. Cumulative data are presented (FSHD: mean 71 µm, SD 23 µm; Control: mean 59 µm, SD 17 µm), <i>p</i><0.001, Wilcoxon test.</p

Additional file 1 of Prospective and Mendelian randomization analyses on the association of circulating fatty acid binding protein 4 (FABP-4) and risk of colorectal cancer

Additional file 1: Table S1. Baseline characteristics by cases and controls. Table S2. Baseline characteristics by cases and controls, stratified by sex. Table S3. Baseline characteristics by sex in control participants. Table S4. Baseline characteristics by FABP4 quintiles in male controls. Table S5. Baseline characteristics by FABP4 quintiles in female controls. Table S6. Association of FABP-4 and risk of colorectal cancer with exclusion of people with diabetes and first 2 years of follow-up. Table S7. Association of FABP-4 and risk of colorectal cancer stratified by sex and subsite. Table S8. Colocalization analysis for FABP-4-colorectal cancer associations with prior probability p = 10-5. Table S9. Colocalization analysis for FABP-4-colorectal cancer associations with prior probability p = 10-4. Figure S1. Assumed directed acyclic graph (DAG) on potentially causal pathways in the association between FABP-4 and colorectal cancer risk and potentially confounding factors. Figure S2. Fixed-effects inverse variance–weighted Mendelian randomization analyses of FABP-4 and risk of colorectal cancer and its subsites. Figure S3. Cis Mendelian randomization analyses (Wald ratio) of FABP-4 and risk of colorectal cancer and its subsites. Suppl. text 1. GECCO Consortium funding