Aufbau des bundesdeutschen Zentralregisters für Patienten mit Alpha-1-Antitrypsin-Mangel - Untersuchung der aktuellen Versorgungssituation und Versorgungsqualität in Deutschland

AATD (Alpha-1-Antitrypsin-Mangel)ist eine Erkrankung, die weltweit vorkommt aber dennoch im Bewusstsein der Bevölkerung noch nicht ausreichend verankert ist. Wir konnten zeigen, dass es möglich ist, anhand eines kostenlosen Diagnostik-Programms in Verbindung mit Informations- und Aufklärungskampagnen eine Vielzahl von Personen mit AATD zu identifizieren. Gleichzeitig war es gelungen ein nationales Register für betroffene Patienten aufzubauen um deren Versorgungssituation und Versorgungsqualität zu erfassen

Tissue-preserving treatment with non-invasive physical plasma of cervical intraepithelial neoplasia—a prospective controlled clinical trial

ObjectiveCervical cancer represents the fourth leading cause of cancer among women and is associated with over 311,000 annual deaths worldwide. Timely diagnosis is crucial given the lengthy pre-cancerous phase, which is typified by cervical intraepithelial neoplastic lesions. However, current treatment methods are often tissue-destructive and can be accompanied by severe side effects. To address these concerns, our study introduces a novel, gentle approach for the tissue-preserving treatment of CIN lesions.ResultsWe present findings of a controlled, prospective, single-armed phase IIb clinical trial performed at the Department for Women’s Health, Tübingen, Germany. From September 2017 to March 2022 we assessed 570 participants for study eligibility. Of the screened patients, 63 participants met with CIN1/2 lesions met the inclusion criteria and were treated with non-invasive physical plasma (NIPP). Assessment of treatment efficacy was based on a comprehensive analysis of histological and cytological findings, along with high-risk HPV infection load at 3 and 6 months post-treatment. Comparative analyses were performed retrospectively with data obtained from 287 untreated patients in the control group. Our findings indicate that patients treated with NIPP experienced an 86.2% rate of full remission, along with a 3.4% rate of partial remission of CIN lesions, which compares favorably to the control group’s rates of 40.4% and 4.5%, respectively. Additionally, we observed a twofold reduction in high-risk HPV infections following NIPP treatment. Minor side effects were observed, such as mild pain during treatment and short-term smear bleeding or increased vaginal discharge within 24 h after treatment. Given the experimental nature of NIPP treatment and the availability of established standard treatments, our study was designed as a non-randomized study.ConclusionNIPP treatment offers a highly flexible and easy-to-apply method for treating pre-cancerous CIN1/2 lesions. This non-invasive approach is notable for its tissue-preserving nature, making it a promising alternative to current excisional and ablative treatments. CIN1/2 lesions were employed as preliminary in vivo models for the targeted treatment of CIN3 lesions.Clinical trial registrationhttps://www.clinicaltrials.gov, identifier NCT03218436

What difference does a negative opinion climate make? Assessing immigrants’ low-wage risks in times of heightened anti-immigrant attitudes

The paper argues that a negative opinion climate vis-à-vis immigrants increases the low-wage risks of second-generation immigrants. Analysing data from 18 waves of the German Socio-Economic Panel and using a matched case design, we provide strong support for this hypothesis. The findings complement studies of immigrants’ wages, bringing evidence for their sensitivity to contextual factors. They also complement recent findings from firm-level studies that found that the wage bias in cases of second-generation immigrants reflects the perception of competition between them and German workers

Aufbau des bundesdeutschen Zentralregisters für Patienten mit Alpha-1-Antitrypsin-Mangel - Untersuchung der aktuellen Versorgungssituation und Versorgungsqualität in Deutschland

AATD (Alpha-1-Antitrypsin-Mangel)ist eine Erkrankung, die weltweit vorkommt aber dennoch im Bewusstsein der Bevölkerung noch nicht ausreichend verankert ist. Wir konnten zeigen, dass es möglich ist, anhand eines kostenlosen Diagnostik-Programms in Verbindung mit Informations- und Aufklärungskampagnen eine Vielzahl von Personen mit AATD zu identifizieren. Gleichzeitig war es gelungen ein nationales Register für betroffene Patienten aufzubauen um deren Versorgungssituation und Versorgungsqualität zu erfassen

A retrospective analysis of perioperative complications associated with retropubic tension-free vaginal tape in 960 women

PURPOSE: The purpose is to analyse perioperative complications associated with the retropubic tension-free vaginal tape (TVT) procedure and their management. METHODS: This retrospective, monocentric cohort study included 960 women after retropubic TVT procedure performed by one surgeon from 2011 to 2016. Complications were identified up to 6 weeks after the procedure, divided into specific and general complications and classified based on the Clavien–Dindo (CD) Classification. A visit 6 weeks after the surgical procedure was attended by all patients. RESULTS: 77 complications, of which 74 occurred postoperatively and 3 intraoperatively, affecting 72 (7.5%) out of 960 women. Urinary retention and voiding problems were the most common complication. The mean age of women suffering complications was 3.4 years higher in comparison to the mean age of women without complications (p = 0.036). The Body Mass Index (BMI) of the group of women with perioperative complications had an average BMI which was 0.5 kg/m(2) lower than the average BMI of the women without complications. 22 (12.8%) out of 172 women with recurrent stress incontinence had postoperative complications, of which 21 were related to the TVT. CONCLUSION: The retropubic TVT is a surgical procedure associated with a low number of perioperative complications, even in the group of elderly and overweight women, as well as in cases of recurrent stress incontinence

Adhesion prevention after endometriosis surgery — results of a randomized, controlled clinical trial with second-look laparoscopy

Purpose!#!Adhesion formation after endometriosis surgery is a severe problem affecting up to 90% of patients. Possible complications include chronic pain, ileus, and secondary infertility. Therefore, effective adhesion prophylaxis is desirable, for which the adhesion barrier 4DryField!##!Methods!#!Fifty patients with extensive and deep infiltrating endometriosis were included in this prospective, randomized, controlled clinical trial with two-staged laparoscopic approach. The patients were randomized into two groups, one receiving 4DryField!##!Results!#!Both groups were comparable with respect to relevant patient parameters. Severity and extent of adhesions were significantly reduced by 85% in the 4DryField!##!Conclusion!#!Adhesion formation could be reduced significantly by 85% by application of the adhesion barrier 4DryField!##!Trial registration!#!Trial registration main ID: DRKS00014720, secondary ID: U1111-1213-4142; date of registration 09th May 2018