Flowchart of included patients.

<p>Flowchart of included patients.</p

Daily fluid volumes presented as median with interquartile range (error bars).

<p>Resuscitation fluid was defined as crystalloids and colloids given from 24 hours prior to randomisation (day 0) until end of day 3 in the 6S trial.</p

Patient baseline and hospital characteristics.

<p>Patient baseline and hospital characteristics.</p

Associations between hospital characteristics and fluid volumes given from day 0 to day 3.

<p>(n = 654).</p

Selection of the study cohort.

<p>Selection of the study cohort.</p

Survival Function for ‘Priority of Surgery’.

<p>Survival Function for ‘Priority of Surgery’.</p

Survival function for ‘Length of Hospital Stay’ (LOS).

<p>Survival function for ‘Length of Hospital Stay’ (LOS).</p

Cox regression analyses.

<p>ASA  =  American Society of Anesthesiology classification of physical status; NS  =  non significant. Both Surgical delay, p = 0.08 and Time of Surgery, p = 0.20 were non significant in the univariate analysis. Other Non significant covariates in the univariate analyses were: Time of year, p = 0.67; Time of Admission, p = 0.25; Type of hospital, p = 0.19.</p

Characteristics of the 6 143 patients.

<p>ASA  =  American Society of Anesthesiology classification of physical status.</p

Additional file 1: of Gabapentin in procedure-specific postoperative pain management – preplanned subgroup analyses from a systematic review with meta-analyses and trial sequential analyses

Appendix 1. Search strategies. Appendix 2. Opioid conversion table. Appendix 3. Forest plot of 24-h morphine consumption from all trials estimates. Appendix 4. TSA of 24-h morphine consumption in the cholecystectomy subgroup, all trials. Appendix 5. TSA of 24-h morphine consumption in the hysterectomy subgroup, all trials. Appendix 6. TSA of 24-h morphine consumption in the mastectomy subgroup, all trials. Appendix 7. TSA of 24-h morphine consumption in the orthopedic arthroplasty subgroup, all trials. Appendix 8. TSA of 24-h morphine consumption in the spinal subgroup, all trials. Appendix 9. TSA of 24-h morphine consumption in the thoracic surgery subgroup, all trials. Appendix 10. Forest plot of SAEs, all trials. Appendix 11. TSA of SAEs in the thoracic surgery subgroup, all trials. Appendix 12. Forest plot of VAS 6 h at rest, all trials. Appendix 13. Forest plot of VAS 6 h at mobilization, all trials. Appendix 14. Forest plot of VAS 24 h at rest, all trials. Appendix 15. Forest plot of VAS 24 h at mobilization, all trials. Appendix 16. Forest plot nausea, all trials. Appendix 17. Forest plot vomiting, all trials. Appendix 18. Forest plot sedation, all trials. Appendix 19. Forest plot dizziness, all trials. (PDF 736 kb