Das Reich des kleineren Übels: Jean-Claude Michéa über die liberale Gesellschaft

Jean-Claude Michéa: Das Reich des kleineren Übels: Über die liberale Gesellschaft. Berlin: Matthes & Seitz 2014. 978395757015

Alter Wein in neuen Schläuchen: Rezension zu "Das Jahrhundert des Populismus: Geschichte - Theorie - Kritik" von Pierre Rosanvallon

Pierre Rosanvallon: Das Jahrhundert des Populismus - Geschichte, Theorie, Kritik. Hamburg: Hamburger Edition 2020. 978-3-86854-347-

Methodologies Matter

This article compares Axel Honneth’s method of normative reconstruction with John Dewey's method of problem-solving. We argue that Dewey’s method is more open to “radical” measures of social transformation because it does not bear Honneth’s inherent conservative implications. Dewey’s “more radical” measures include, in particular, demands for a socialist transformation of the economy, whereas Honneth’s approach leads to mere reformist proposals within the existing property system, such as the introduction of a minimum wage. We situate this juxtaposition in the more recent discussion on the methodology of critical theories and argue that, despite the recent turn of Critical Theorists towards Dewey’s pragmatic philosophy, the potential of the latter has so far been largely neglected

Seeding of epithelial cells into circulation during surgery for breast cancer: the fate of malignant and benign mobilized cells

BACKGROUND: Surgery of malignant tumors has long been suspected to be the reason for enhancement of growth of metastases with fatal outcome. This often prevented surgeons from touching the tumor if not absolutely necessary. We have shown in lung cancer patients that surgery, itself, leads to mobilization of tumor cells into peripheral blood. Some of the mobilized cells finding an appropriate niche might grow to form early metastases. Monitoring of tumor cell release during and the fate of such cells after surgery for breast cancer may help to reveal how metastases develop after surgery. METHOD: We used the MAINTRAC(® )analysis, a new tool for online observation of circulating epithelial cells, to monitor the number of epithelial cells before, 30 min, 60 min, three and seven days after surgery and during subsequent variable follow up in breast cancer patients. RESULTS: Circulating epithelial cells were already present before surgery in all patients. During the first 30–60 min after surgery values did not change immediately. They started increasing during the following 3 to 4 days up to thousand fold in 85% of treated patients in spite of complete resection of the tumor with tumor free margins in all patients. There was a subsequent re-decrease, with cell numbers remaining above pre-surgery values in 58% of cases until onset of chemotherapy. In a few cases, where no further therapy or only hormone treatment was given due to low risk stage, cell numbers were monitored for up to three years. They remained elevated with no or a slow decrease over time. This was in contrast to the observation in a patient where surgery was performed for benign condition. She was monitored before surgery with no cells detectable. Epithelial cells increased up to more than 50 000 after surgery but followed by a complete reduction to below the threshold of detection. CONCLUSION: Frequently before but regularly during surgery of breast cancer, epithelial cells are mobilized into circulation. Part of these cells, most probably normal or apoptotic cells, are cleared from the circulation as also shown to occur in benign conditions. After resection even if complete and of small tumors, cells can remain in the circulation over long times. Such cells may remain "dormant" but might settle and grow into metastases, if they find appropriate conditions, even after years