Connectivity profile of the striatum to the cortex.

<p>(A) Average connectivity measures per surface unit for each nucleus and each gyrus. (B) Cortical gyri constituting the connectivity profile of each nucleus.</p

Cortico-striatal fibre tracts in one healthy subject and one HD patient.

<p>Only 1% of the actual fibre tracts were randomly selected and represented for a better rendering. In the patient, the volume of the striatum was reduced and the number of tracts obtained for each nucleus was decreased.</p

Percentage difference of connectivity for the striatum nuclei.

<p>The figure shows the percentage difference of connectivity between healthy subjects and HD patients, obtained for each nucleus of the striatum and cortical gyri belonging to the connectivity profile of the nucleus and presenting a significant connectivity difference between healthy subjects and HD patients.</p

Volumes of the deep nuclei for healthy subjects and HD patients.

<p>Points represent mean values and bars standard deviations.</p

Clinical characteristics of the subjects.

<p>Clinical characteristics of the subjects.</p

Selection of the connections of the striatum for a healthy subject.

<p>(A) selection of the tracts that intersect the striatum, (B) selection of only the direct tracts that link the striatum to the cortex. Only 1% of the actual fibre tracts were randomly selected and represented for a better rendering.</p

Cortico-striatal tracts selection.

<p>(A) If all basal ganglia were not taken into account in the selection process, direct connections (blue segment) but also indirect connections (red segment) of the striatum to the cortex would be studied. (B) A tract was considered as intersecting a nucleus if at least 2 points of the tract intersected the nucleus. (C) A tract was considered as intersecting the cortical surface if its distance to the surface was less than 2 mm.</p