1,523 research outputs found
Investigations on nucleophilic layers made with a novel plasma jet technique
In this work a novel plasma jet technique is used for the deposition of nucleophilic films based on (3-aminopropyl)trimethoxysilane at atmospheric pressure. Film deposition was varied with regard to duty cycles and working distance. Spectral ellipsometry and chemical derivatization with 4-(trifluoromethyl)benzaldehyde using ATR- FTIR spectroscopy measurements were used to characterize the films. It was found that the layer thickness and the film composition are mainly influenced by the duty cycle
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Projecting Need for a COVID-19 Alternative Care Site (ACS) Austin, TX
To support the city of Austin and Travis County in responding to the threatening rise in COVID-19 hospitalizations, we used a data-driven model of COVID-19 transmission in the Austin-Round Rock MSA to project hospitalizations until February 4th, estimate the risk that cases will exceeding local capacity, and determine effective triggers for opening an alternative care site (ACS) to expand capacity. Note that the results presented herein are based on multiple assumptions about the transmission rate and age-specific severity of COVID-19 and do not represent the full range of uncertainty. Rather, they are meant to provide plausible scenarios for COVID-19 healthcare demand and inform decisions that balance the high costs of establishing an ACS with the risks of outstripping local healthcare capacity.Integrative Biolog
Senile Systemic Amyloidosis: Clinical Features at Presentation and Outcome
Background Cardiac amyloidosis is a fatal disease whose prognosis and treatment rely on identification of the amyloid type. In our aging population transthyretin amyloidosis (ATTRwt) is common and must be differentiated from other amyloid types. We report the clinical presentation, natural history, and prognostic features of ATTRwt compared with cardiacâisolated AL amyloidosis and calculate the probability of disease diagnosis of ATTRwt from baseline factors.
Methods and Results All patients with biopsyâproven ATTRwt (102 cases) and isolated cardiac AL (36 cases) seen from 2002 to 2011 at the UK National Amyloidosis Center were included. Median survival from the onset of symptoms was 6.07 years in the ATTRwt group and 1.7 years in the AL group. Positive troponin, a pacemaker, and increasing New York Heart Association (NYHA) class were associated with worse survival in ATTRwt patients on univariate analysis. All patients with isolated cardiac AL and 24.1% of patients with ATTRwt had evidence of a plasma cell dyscrasia. Older age and lower Nâterminal proâBâtype natriuretic peptide (NT proâBNP) were factors significantly associated with ATTRwt. Patients aged 70 years and younger with an NT proâBNP <183 pmol/L were more likely to have ATTRwt, as were patients older than 70 years with an NT proâBNP <1420 pmol/L.
Conclusions Factors at baseline associated with a worse outcome in ATTRwt are positive troponin T, a pacemaker, and NYHA class IV symptoms. The age of the patient at diagnosis and NT proâBNP level can aid in distinguishing ATTRwt from AL amyloidosis
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