Hopkins, John

Lachmann, P J

McConnell, I.

English

Sheep were primed to a variety of antigens and the efferent lymphatic from a popliteal lymph node was cannulated. The cannulated node was challenged repeatedly with PPD and all the lymph and cells removed from the animal. During this time the PBL were monitored for reactivity to all antigens (purified protein derivative of tuberculin [PPD], johnin, and keyhole limpet hemocyanin [KLH]) by the vitro transformation assay. The response of these cells to PPD was found to be gradually eliminated after repeated challenge of the cannulated node with that antigen. The response to the other antigens was unimpaired. No depletion of this response to PPD occurred in cannulated sheep when the antigen was given into a noncannulated node. In vivo delayed-type hypersensitivity skin test and helper T cell assays confirmed that there is a specific selection of antigen-reactive cells from the recirculating lymphocyte pool into antigen-stimulated lymph nodes

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Early cellular events in a systemic graft-vs.-host reaction. I. The migration of responding and nonresponding donor lymphocytes.

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Lymph-borne cells of the immune response.

Lymphocyte migration and immune response.

Lymphocyte traffic through lymph nodes draining cell shutdown. Ciba Found.

Migratory behavior of lymphocytes with specific reactivity to alloantigens. II. Selective recruitment to lymphoid cell allografts and their draining lymph nodes.

Organ specificity of lymphocyte migration: mediation by highly selective lymphocyte interaction with organ-specific determinants on high endothelial venules.

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Specific destruction of human endothelial cell monolayers by anti-DR antisera.

Specific unresponsiveness ofrecirculating lymphocytes after exposure to histocompatibility antigen in F1 hybrid rats.

The flow of blood to lymph nodes and its relation to lymphocyte traffic and the immune response.J.

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Specific selection of antigen-reactive lymphocytes into antigenically stimulated lymph nodes in sheep

J Hopkins

I McConnell

P J Lachmann

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Specific selection of antigen-reactive lymphocytes into antigenically stimulated lymph nodes in sheep.

http://jem.rupress.org/content/jem/153/3/706.full.pdf

Specific selection of antigen-reactive lymphocytes into antigenically stimulated lymph nodes in sheep

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