13 research outputs found
Glucose-Regulated Glucose Uptake by Transplanted Muscle Cells Expressing Glucokinase Counteracts Diabetic Hyperglycemia
Mechanism of regulation of 3-hydroxy-3-methylglutaryl coenzyme A reductase activity by low density lipoprotein in human lymphocytes
Glucokinase activation as antidiabetic therapy: effect of nutraceuticals and phytochemicals on glucokinase gene expression and enzymatic activity
Engineering of a Glucose-Responsive Surrogate Cell for Insulin Replacement Therapy of Experimental Insulin-Dependent Diabetes
Expression of Glucokinase in Skeletal Muscle: A New Approach to Counteract Diabetic Hyperglycemia
cDNA Clones for Liver Cytochrome P-450s from Individual Aroclor-Treated Rats: Constitutive Expression of a New P-450 Gene Related to Phenobarbital-Inducible Forms
Characterization of glucokinase polymorphisms associated with Maturity-Onset Diabetes of the Young (MODY2) in Jordanian population
Upstream stimulating factors: highly versatile stress-responsive transcription factors
International audienceUpstream stimulating factors (USF), USF-1 and USF-2, are members of the eucaryotic evolutionary conserved basic-Helix-Loop-Helix-Leucine Zipper transcription factor family. They interact with high affinity to cognate E-box regulatory elements (CANNTG), which are largely represented across the whole genome in eucaryotes. The ubiquitously expressed USF-transcription factors participate in distinct transcriptional processes, mediating recruitment of chromatin remodelling enzymes and interacting with co-activators and members of the transcription pre-initiation complex. Results obtained from both cell lines and knock-out mice indicates that USF factors are key regulators of a wide number of gene regulation networks, including the stress and immune responses, cell cycle and proliferation, lipid and glucid metabolism, and in melanocytes USF-1 has been implicated as a key UV-activated regulator of genes associated with pigmentation. This review will focus on general characteristics of the USF-transcription factors and their place in some regulatory networks