Parity related changes in obesity and some antioxidant vitamins in non-pregnant women of South-Eastern Nigeria

Background: The delivery of many children at short interval is associated with micronutrient depletion and weight gain. However, the relationship between the levels of the micronutrients and the body weight is yet to be ascertained.Objectives: To determine the relationship between parity, body weight and some antioxidant vitamins in non-pregnant Nigerian women.Patients and Methods: Randomly recruited 200 non-pregnant women, comprising 82 primiparous and 118 multiparous women completed the study. Their age, parity, mid-arm circumference (MAC), waist circumference (WC), weight, height and body mass index (BMI) were determined. The serum levels of vitamins A, C and E were assayed using standardmethods.Results: The mean BMI, WC and MAC of the multiparous subjects (parity = 3.0 ± 0.58) were significantly higher than that of the primiparous subjects (parity = 1), (P < 0.05, P < 0.01 and P < 0.01 respectively). Furthermore, there were statistically significant decrease in the vitamin A, vitamin C and vitamin E in multiparous compared with the primiparous women (P < 0.005, P < 0.05 and P < 0.005), respectively.Conclusion: Multiparty enhances weight gain, but depletes antioxidant vitamin micronutrients in non-pregnant Nigerian women

The role of some micronutrients (eldervit) in the management of anaemic pregnant Nigerian women: A preliminary report

CONTEXT: Anaemia continues to be a leading contributor to adverse reproductive outcomes in the developing countries. Although, the commonest cause of anaemia in pregnancy is iron deficiency, the enormous contributions of other micronutrients have been underestimated. As a result, the need to identify relevant micronutrients, whichcomplement iron, in haematopoiesis cannot be over emphasized.OBJECTIVES: To determine the effect of some micronutrients  (Cyanocobalamin, {B12}2500ìg, folic acid 0.7mg, niacin12mg and ascorbic acid 150mg; Eldervit-12) on some haematological parameters of anaemic pregnant women.SUBJECTS AND METHODS: ONE hundred and sixty two (162) anaemic pregnant women aged between 18-38 years were recruited into the study, and randomly divided into two groups. The test group was given two weeklyEldervit-12 injections intramuscularly, and the control group was given placebo (water for injection). Packed cell volume (PCV), reticulocyte count, white cell count and platelet count were estimated before and at the end of the injections using established methods. Student t-test was used to determine test for significance between the groups.RESULTS: The PCV increased significantly from 25.9± 2.2% and 26.2± 2.2% to 37.3% ± 2.6% and 32.4%± 1.9% respectively for test and control (P< 0.001). The PCV increase was however, significantly higher in the test when compared with the control (P< 0.001). The reticulocyte count also increased significantly from 2.2% ± 0.7% and 2.3%± 0.7% to 4.7%V 0.8 % and 2.9% ± 0.7 % respectively for test and control (P<0.001). But the test showed a more significant increase than the control (P< 0.001). There were no significant differences in the WBC and platelet counts (P> 0.05).CONCLUSION: Additional micronutrients play a vital role in the management of anaemia in pregnancy. Efforts should be made to qualify and quantify these in other to obtain the actual daily requirements.Key words (Anaemia, Pregnancy, Micronutrients, Haematological parameters.

Lactational exposure to an aqueous extract of Hibiscus Sabdariffa (Hs) accelerates offspring's early postnatal growth in Sprague-Dawley rats

No Abstract. Journal of Experimental and Clinical Anatomy Vol. 5(1) 2006: 6-

Effect of inutero exposure to an aqueous extract of hibicus sabdariffa on offspring's postnatal growth in Sprague-Dawley rats

In folk medicine, extracts of Hibiscus Sabdariffa (HS) are used in the treatment of several complaints including high blood pressure, liver diseases and fever. To the best of our knowledge, no documented evidence exists on the effect of inutero exposure to an aqueous extract of HS on postnatal growth. The purpose of the present study, therefore, was to investigate this. Three groups of pregnant rats were used for this study. Group C had tap water while groups A and B had 0.6g and 1.8g HS extract respectively in 100ml tap water to drink throughout pregnancy. All groups had normal rat chow ad libitum. On the day of birth, birth weights were recorded and two pups each from dams in groups A and B were substituted for 4 pups from dams in group C such that dams in group C had two pups each from groups A and B and at least two pups from its own litters to nurse. Thereafter, weights were recorded at 10days, 14days, 20days and 34 days postpartum. Results of the present study show a statistically significant (

The effect of an aqueous extract of Hibiscus sabdariffa on gestational weight gain, pregnancy outcome and postpartum weight retention in Sprague-Dawley (SD) rats

Pregnancy and increased gestational weight gain has been observed to be associated with increased postpartum weight retention. The present study was designed to investigate the effect of an aqueous extract of Hibiscus Sabdariffa (HSE) on gestational weight gain, pregnancy outcome and postpartum weight retention in Sprague-Dawley rats. Fifteen pregnant SD rats were randomly assigned to groups A, B and C. Group C had tap water while groups A and B had 0.6g HSE and 1.8g HSE respectively in 100ml tap water to drink throughout pregnancy and through 34 days postpartum. The rats in all groups were fed normal rat chow ad libitum. The weights of the rats were measured daily throughout pregnancy and at delivery and at 10, 14, 20 and 34 days postpartum. Results show statistically significant (

Tumours of the breast in Orlu - Nigeria

No abstrac

Diseases Of The Prostate Among Igbos Of Southeastern Nigeria.

Background Worldwide, prostate cancer ranks third in cancer incidence and sixth in cancer mortality among men. Blacks have been found to have the highest prevalence of prostate cancer, the earliest age of onset, and the greatest mortality rate from the disease. Nigeria has the highest concentration of black people of any country in the world and in Nigeria, the incidence of cancer of the prostate among Yoruba men has been documented but scanty data exist for Igbo men. Study design This is a retrospective study of all prostate specimens diagnosed histopathologically and analyzed with regard to tumour type and their biological behaviour. Results A total of 4400 surgical biopsy specimens were registered of which 282 (6.4%) were of the prostate gland. Seventy-four (26.2%) of the prostate specimens were malignant while 196 (69.5%) were benign prostatic hyperplasia (BPH). All the cancers seen were adenocarcinomas. The mean age of the patients with prostate cancer was 67+7.6years and those with BPH had a mean of 65+8years. Conclusion There is a steady increase in prostatic diseases from the 5th decade and reaching a peak in the 7th decade with neoplastic diseases accounting for 95.7%. Keywords: Cancer, hyperplasia, Igbo, Nigerian, Prostate. Ebonyi Medical Journal Vol. 7 (1&2) 2008: pp. 8-1

Mixed Mesodermal Tumour Of The Ovary Coexisting With Adenocarcinoma Of The Ileum In A Postmenopausal Nigerian Woman

Mesodermal mixed tumour of the ovary is a very uncommon tumour constituting less than 1% of ovarian cancers. It is a very aggressive tumour with post operative survival usually shorter than 24 months. Primary adenocarcinoma of the small bowel is also a rare malignancy constituting about 1% of gastrointestinal cancers and is associated with poor survival outcome. And uncommon is adenocarcinoma of the ileum. It is highly unusual for two rare and aggressive cancers to coexist in the same patient. This to my knowledge has not been reported in the literature. Keywords: vEbonyi Medical Journal Vol. 6 (2) 2007: pp. 114-11

Endometrial Biopsy and Hystopathological Diagnosis - A 10 year Review

Background: Appropriate diagnosis is the mainstay of proper and effective management. For an appropriate histopathological diagnosis to be made, an accurate record of clinical details including sex is essential. The completeness or otherwise of data supplied by clinicians submitting endometrial biopsy specimen was investigated in this study. Method: A retrospective analysis of request forms of endometrial biopsies submitted at the Morbid anatomy Department of the Lagos University Teaching Hospital from 1981 to 1990 and their histopathological diagnosis. Results: The age of the patient was not indicated in 50.2% of the request forms, while 7.8% had no clinical history/diagnosis recorded. Of 1,005 infertile patients and 608 with menstrual disorders, only 8.5% had their last menstrual periods or drug history stated on the forms. In those with only infertility as the indication for curettage, only 28% had their last menstrual period state. Conclusion: Data supplied by many clinicians while requesting for histopathological examination is inadequate. This is likely to affect the accuracy of the histopathological diagnosis. Key Words: Endometrial biopsy, Histopathological diagnosis, D & C (dilatation and curettage). Jnl of Medical Investigation and Practice Vol.1 2000: 33-3

Menstruation and its associated peculiarities in Nigerian girls

No Abstract