Optimum Structure of CT Probe and sｐectral Components in 2-D Magnetic Field Visualization Based on the Magnetic CT Method

The precise measurement of two-dimensional and three-dimensional magnetic flux distribution is indispensable for the development of magnetic machinery and device. The magnetic computed tomography (CT) method is proposed to visualize magnetic flux distribution. In order to determine the optimum structure of the magnetic CT probe, an evaluation model is employed to simulate the reconstruction accuracy of magnetic flux distribution. The spectrum of a distribution of magnetic field has been discussed of the components. As a result, the numerical simulation shows the optimum design of the multi layer CT probe

Measurement and visualization of three-dimensional radial and vectored magnetic field distribution by use of the magnetic CT method

The measurement and visualization of three-dimensional radial and vectored magnetic field distribution based on the magnetic computed tomography (CT) method have been reported. Applying the method, it is possible to measure a surrounding magnetic field such as a spherical region by using a simple probe, which is not limited to the measurement of two-dimensional magnetic field distribution. It has been shown that the magnetic field distribution of a spherical surface covering a sample object can be visualized from the measured and calculated results with a spherical CT probe and CT reconstruction algorithm

Measurement and Visualization of Three-Dimensional Radial and Vectored Magnetic Field Distribution by Use od the Magnetic CT Method

The measurement and visualization of three-dimensional radial and vectored magnetic field distribution based on the magnetic computed tomography (CT) method have been reported. Applying the method, it is possible to measure a surrounding magnetic field such as a spherical region by using a simple probe, which is not limited to the measurement of two-dimensional magnetic field distribution. It has been shown that the magnetic field distribution of a spherical surface covering a sample object can be visualized from the measured and calculated results with a spherical CT probe and CT reconstruction algorithm

Novel GMR Sensor for Estimation of Magnetic Nanoparticles inside Minute Cavities

Utilization of magnetic nanoparticles in biomedicine has seen an unprecedented growth in recent years. The ability to accurately estimate magnetic nanoparticles inside small areas of the body provides an advantage in hyperthermia therapy, a form of cancer treatment. This paper concentrates on a novel giant magnetoresistance (GMR) needle-type sensor to detect and estimate low concentration magnetic fluid inside minute agar cavities injected with magnetic fluid. Theoretical analysis, experimental results and information on the fabricated GMR needle-type sensor are reported. The experimental results show a favorable agreement to the analytical analysis, supporting the potential use of the GMR needle-type sensor in hyperthermia therapy Asia-Pacific Symposium on Applied Electromagnetics and Mechanics (APSAEM08

Eddy-Current Testing Probe With Spin-Valve Type GMR Sensor for Printed Circuit Board Inspection

This paper proposes an eddy-current testing (ECT) probe composed of a spin-valve giant magnetoresistance (SV-GMR) sensor and a meander coil for the inspection of bare printed circuit board. The SV-GMR sensor serves as a magnetic sensor for the ECT probe to sense the variation of the magnetic field distribution occurred on the printed circuit board. The SV-GMR sensor is used specifically to detect the changing magnetic field distribution occurred at the defect point. The characteristics of the proposed probe are discussed in this paper. The comparisons of signal-to-noise ratios obtained from ECT probe with SV-GMR sensor and with solenoid coil verify that the applying of SV-GMR sensor to the ECT probe can improve the PCB inspection results

Anaplastic lymphoma kinase (ALK) inhibitor response in neuroblastoma is highly correlated with ALK mutation status, ALK mRNA and protein levels

Background In pediatric neuroblastoma (NBL), high anaplastic lymphoma kinase (ALK) levels appear to be correlated with an unfavorable prognosis, regardless of ALK mutation status. This suggests a therapeutic role for ALK inhibitors in NBL patients. We examined the correlation between levels of ALK, phosphorylated ALK (pALK) and downstream signaling proteins and response to ALK inhibition in a large panel of both ALK mutated and wild type (WT) NBL cell lines. Methods We measured protein levels by western blot and ALK inhibitor sensitivity (TAE684) by viability assays in 19 NBL cell lines of which 6 had a point mutation and 4 an amplification of the ALK gene. Results ALK 220 kDa (p=0.01) and ALK 140 kDa (p= 0.03) protein levels were higher in ALK mutant than WT cell lines. Response to ALK inhibition was significantly correlated with ALK protein levels (p<0.01). ALK mutant cell lines (n=4) were 14,9 fold (p<0,01) more sensitive to ALK inhibition than eight WT cell lines. Conclusion NBL cell lines often express ALK at high levels and are responsive to ALK inhibitors. Mutated cell lines express ALK at higher levels, which may define their superior response to ALK inhibition