A prospective compound screening contest identified broader inhibitors for Sirtuin 1

Potential inhibitors of a target biomolecule, NAD-dependent deacetylase Sirtuin 1, were identified by a contest-based approach, in which participants were asked to propose a prioritized list of 400 compounds from a designated compound library containing 2.5 million compounds using in silico methods and scoring. Our aim was to identify target enzyme inhibitors and to benchmark computer-aided drug discovery methods under the same experimental conditions. Collecting compound lists derived from various methods is advantageous for aggregating compounds with structurally diversified properties compared with the use of a single method. The inhibitory action on Sirtuin 1 of approximately half of the proposed compounds was experimentally accessed. Ultimately, seven structurally diverse compounds were identified

Temporal variability of export POC flux estimated from Th-234 in the Antarctic SIZ in summer 2001-2002

26th Symposium on Polar Biolog

In silico Spleen Tyrosine Kinase Inhibitor Screening by ChooseLD

<p>IPSJ Transactions on Bioinformatics Vol. 8 (2015) pp. 14-20</p> <p> </p

Senecio flammeus Turcz.

原著和名: タカネコウリンクヮ科名: キク科 = Compositae採集地: 熊本県 阿蘇郡 波野村 (肥後 阿蘇郡 波野村)採集日: 1974/8/8採集者: 萩庭丈壽整理番号: JH007516国立科学博物館整理番号: TNS-VS-95751