Cox regression analysis of coronary plaque assessment for the composite endpoint of cardiac events.

*<p>Dichotomous variable (yes or no). CCS, coronary calcium score; CCTA, coronary CT-angiography; hs-cTnT, high-sensitivity cardiac troponin T; CAD, coronary artery disease; Q4, fourth quartile.</p

Cox regression analysis of cardiac biomarkers for the composite endpoint of cardiac events.

*<p>Dichotomous variable (yes or no); Q4, fourth quartile.</p>†<p>URL = upper reference limit (used for diagnosis).</p><p>hs-cTnT, high-sensitivity cardiac troponin T; NT-proBNP, N-terminal pro-brain-type natriuretic peptide; hsCRP, high-sensitive C-reactive protein.</p

Flowchart of the study design.

<p>* Early revascularizations within 90 days after CCTA were censored at the time of PCI or CABG.</p

Baseline characteristics of the study population.

*<p>Cardiac events: PCI>90 days, CABG>90 days, ACS, cardiac mortality.</p>†<p>n = 612 underwent echocardiography.</p><p>BP, blood pressure; LDL-C, low-density lipoprotein cholesterol; HDL-C, high-density lipoprotein cholesterol; hsCRP, high-sensitive C-reactive protein; hs-cTnT, high-sensitivity cardiac troponin T; NT-proBNP, N-terminal pro-brain-type natriuretic peptide; LVEF, left ventricular ejection fraction; IVSEDWT, interventricular septum end-diastolic wall thickness; PWEDWT, posterior wall end-diastolic wall thickness; LVMASS, left ventricular mass; CCTA, coronary CT-angiography; CAD, coronary artery disease.</p

Plaque morphology in patients, stratified by eGFR.

<p>Odds ratios for plaque morphology, stratified by eGFR. Patients with normal renal function (eGFR ≥90 mL/min/1.73 m²) were used as reference category (OR = 1.00).</p

Flowchart of the study design.

<p>Flowchart of the study design.</p

Presence of any, moderate and severe coronary plaque in patients, stratified by eGFR.

<p>Odds ratios for the presence of any and severe coronary plaques, stratified by eGFR. Patients with normal renal function (eGFR ≥90 mL/min/1.73 m²) were used as reference category (OR = 1.00).</p

Mean coronary calcium score in the different CKD-categories.

<p>The graph clearly shows that the mean calcium score increased significantly with decreasing renal function.</p

Baseline characteristics of the study population stratified by eGFR.

<p>Baseline characteristics, stratified by eGFR. eGFR, estimated glomerular filtration rate; BMI, body mass index; BP, blood pressure; HDL-C, high-density lipoprotein cholesterol; LDL-C, low-density lipoprotein cholesterol. * Triglycerides measured in n = 1,786. ** Glucose measured in n = 1,568.</p

Multivariable logistic regression of risk factors for the presence of any and severe coronary plaque.

<p>Multivariable logistic regression analysis was performed with known traditional cardiovascular risk factors as well as the CKD categories. Patients with normal renal function (eGFR ≥90 mL/min/1.73 m²) were used as reference category (OR = 1.00).</p