Catatonia en la población infantojuvenil

La catatonia es un síndrome neuropsiquiátrico descrito en 1874 por el Dr. Karl Kahlbaum. Se caracteriza por presentar mutismo, estupor, catalepsia, estereotipias, negativismo y ecofenómenos, entre otros. Si bien se encuentra bien definido en adultos, existe poca información referida a su presentación en población infantil. En el presente artículo se revisarán diferentes aspectos de la presentación clínica y del abordaje terapéutico de este síndrome.Catatonia is a neuropsychiatric syndrome described by Karl Kahlbaum in 1874. It is characterized by mutism, stupor, catalepsy, stereotypes, negativism and ecophenomena, among others. Although it is well described in adults, there is little information regarding its presentation in children. In this article different aspects of the clinical presentation and therapeutic approach of this syndrome will be reviewed

Trastorno por déficit atencional con hiperactividad en la población infantojuvenil

El Trastorno por déficit atencional con hiperactividad (TDAH) es un trastorno crónico, del neurodesarrollo con una prevalencia de 5,29% en la población pediátrica. Las manifestaciones clínicas incluyen síntomas de hiperactividad, impulsividad y desatención que conducen a un deterioro funcional en el desarrollo social, familiar y escolar. Si bien en los últimos años ha habido un aumento en su reconocimiento, la heterogeneidad clínica y la alta comorbilidad pueden obstaculizar su diagnóstico. En el presente trabajo se revisarán diferentes aspectos de la presentación clínica y del abordaje terapéutico de este trastorno.The attention hyperactivity disorder (ADHD) is a chronic neurodevelopmental disorder with a prevalence of 5.24% in pediatric population. The clinical presentation includes symptoms of hyperactivity, impulsivity and inattention with a functional impairment in social, family and scholar development. Even though in the last years it has been well recognized, its clinical heterogeneity and high comorbidity hampers its diagnosis. In this article different aspects of the clinical presentation and therapeutic approach of this disorder will be reviewed

Improving clinical paediatric research and learning from COVID-19: recommendations by the Conect4Children expert advice group

none42Background: The COVID-19 pandemic has had a devastating impact on multiple aspects of healthcare, but has also triggered new ways of working, stimulated novel approaches in clinical research and reinforced the value of previous innovations. Conect4children (c4c, www.conect4children.org) is a large collaborative European network to facilitate the development of new medicines for paediatric populations, and is made up of 35 academic and 10 industry partners from 20 European countries, more than 50 third parties, and around 500 affiliated partners. Methods: We summarise aspects of clinical research in paediatrics stimulated and reinforced by COVID-19 that the Conect4children group recommends regulators, sponsors, and investigators retain for the future, to enhance the efficiency, reduce the cost and burden of medicines and non-interventional studies, and deliver research-equity. Findings: We summarise aspects of clinical research in paediatrics stimulated and reinforced by COVID-19 that the Conect4children group recommends regulators, sponsors, and investigators retain for the future, to enhance the efficiency, reduce the cost and burden of medicines and non-interventional studies, and deliver research-equityWe provide examples of research innovation, and follow this with recommendations to improve the efficiency of future trials, drawing on industry perspectives, regulatory considerations, infrastructure requirements and parent–patient–public involvement. We end with a comment on progress made towards greater international harmonisation of paediatric research and how lessons learned from COVID-19 studies might assist in further improvements in this important area.noneRamanan A.V.; Modi N.; de Wildt S.N.; Aurich B.; Bakhtadze S.; Sirvent F.J.B.; Cabanas F.; Campbell L.; Casanova M.; Charlton P.; Crandall W.; Eichler I.; Fregonese L.; Hawcutt D.B.; Iveli P.; Jaki T.; Jocic-Jakubi B.; Johnson M.; Kaguelidou F.; Karadag B.; Kelly L.E.; Lim M.; Moreno C.; Neumann E.; Ollivier C.; Oualha M.; Raffaeli G.; Ribeiro M.A.; Roilides E.; de Rojas T.; Simon A.R.S.; Ruperto N.; Scarpa M.; Schwab M.; Siapkara A.; Singh Y.; Smits A.; Striano P.; Urru S.A.M.; Vivarelli M.; de Wildt S.; Zivkoviz Z.Ramanan, A. V.; Modi, N.; de Wildt, S. N.; Aurich, B.; Bakhtadze, S.; Sirvent, F. J. B.; Cabanas, F.; Campbell, L.; Casanova, M.; Charlton, P.; Crandall, W.; Eichler, I.; Fregonese, L.; Hawcutt, D. B.; Iveli, P.; Jaki, T.; Jocic-Jakubi, B.; Johnson, M.; Kaguelidou, F.; Karadag, B.; Kelly, L. E.; Lim, M.; Moreno, C.; Neumann, E.; Ollivier, C.; Oualha, M.; Raffaeli, G.; Ribeiro, M. A.; Roilides, E.; de Rojas, T.; Simon, A. R. S.; Ruperto, N.; Scarpa, M.; Schwab, M.; Siapkara, A.; Singh, Y.; Smits, A.; Striano, P.; Urru, S. A. M.; Vivarelli, M.; de Wildt, S.; Zivkoviz, Z