Complementary addressed modification of oligonucleotide d(pGpGpCpGpGpA) with platinum derivative of oligonucleotide d(pTpCpCpGpCpCpTpTpT)

AbstractNew heterobifunctional reagent [BrPt(dien)—(CH2)6—(dien)Pt(H2O)]3+ (I) (− dien = diethylenetriamine residue) is proposed for preparation of complementary addressed reagents, reactive derivatives of oligonucleotides and polynucleotides. Two reactive groupings of (I) bind to oligonucleotides at different rates due to the higher reactivity of −[(dien)Pt(H2O)]2+ as compared to −[(dien)Pt Br]+. Using (I), bromodiethylenetriaminoplatinum group was attached to the oligonucleotide d(pTpCpCpGpCpCpTpTpT) (II) by rapid reaction of aquatriaminoplatinum group of (I) with guanosine residue of (II). The reactive oligonucleotide derivative III thus obtained was shown to modify predominantly 5′-terminal guanosine residue in the complementary oligonucleotide d(pGpGpCpGpGpA) (IV)

The Impact of Isotopic Composition of Lead on the Neutron-Physical Characteristics of Fast Reactor with Liquid Metal Coolant

It is well known, that lead coolant, highly enriched by 208Pb, has some advantages over other coolants. It is predicted that the use of 208Pb in the reactor core will lead to an increase in the production of plutonium and transmutation of long-lived decay products. The main objective of this paper was to investigate the influence of the isotopic composition on the fast reactor neutron-physical characteristics. For this purpose we used the RBETS-M benchmark - a fast energy reactor that includes 12 zones with different sizes and temperatures of the materials. Calculations were performed for homogeneous and heterogeneous models. Our calculations show that the replacement of the coolant with the natural lead to 208Pb and 208Pb together with Bi can substantially improve the neutron-physical characteristics of the fast reactor, in particular by reducing the initial reactivity margin. Studies of the heterogeneity effect in the reactor model showed an increase in the effective multiplication factor of about 1.5% at the end of the campaign

ОПТИМАЛЬНІ УМОВИ ФОРМУВАННЯ ТВОРЧОЇ ДІЯЛЬНОСТІ СТУДЕНТІВ У ПРОЦЕСІ НАВЧАННЯ У ВИЩІЙ ШКОЛІ

The optimal inner and outward conditions of high school students' creative activity are being considered in the article.У статті розкриваються оптимальні зовнішні та внутрішні умови формування творчої дізиьності студентів у вищій школі

ПЕДАГОГІЧНА ТВОРЧІСТЬ ЯК ПОКАЗНИК ГОТОВНОСТІ МАЙБУТНЬОГО ПЕДАГОГА ДО ПРОФЕСІЙНОЇ ДІЯЛЬНОСТІ

The article deals with the pedagogical creative work as a showing o f future teachers' readiness for professional activity

ФОРМУВАННЯ ГОТОВНОСТІ МАЙБУТНЬОГО ВЧИТЕЛЯ ДО ТВОРЧОЇ ДІЯЛЬНОСТІ ЗАСОБАМИ МОДУЛЬНО-БЛОКОВОГО НАВЧАННЯ

At this article is considered possibi lities of modulus-hlocks structured of educational information at the forming of readiness the future teacher to the creative professional activity

ОСНОВИ ПРОФЕСІЙНОЇ ТВОРЧОСТІ МАЙБУТНЬОГО ВЧИТЕЛЯ

The article deals with the pedagogical creative work as a showing of future teachers readiness for professional activity

ФОРМУВАННЯ ГОТОВНОСТІ СТУДЕНТІВ ДО ТВОРЧОЇ ДІЯЛЬНОСТІ ЗАСОБАМИ НАВЧАЛЬНОЇ РОБОТИ

This article deals with various problems of forming readiness for creative pedagogical activities and making optimum conditions of pedagogical process. The author considers several practical methods of developing teachers-to-be creative qualities in the school of higher learning

ФОРМУВАННЯ ТВОРЧИХ ЗДІБНОСТЕЙ МАЙБУТНЬОГО ПЕДАГОГА В УМОВАХ ВИЩОЇ ШКОЛИ

This article deals with the question of formation of formation o f students’ creative abilities. The author shows the specific conditions to form students ’ creative abilities at schools of higher learning.Стаття присвячена питанню формування творчих здібностей студентів. А також розглядаються умови формування творчих здібностей в умовах вищої школи

ФОРМУВАННЯ У СТУДЕНТІВ ГОТОВНОСТІ ДО ТВОРЧОЇ ПРОФЕСІЙНОЇ ДІЯЛЬНОСТІ

The article deals with various problems of forming of readiness for іn ative pedagogical activities, and making optimum conditions of pedagogical proces

ОСНОВНІ АСПЕКТИ ГОТОВНОСТІ МАЙБУТНІХ ФАХІВЦІВ ДО ТВОРЧОЇ ДІЯЛЬНОСТІ

The level of students ' readiness to the creativity is being analyzed; the cause of a tow level of readiness of this complicated personal unit is being predetermined in the article