Studentski znanstveni radovi dostupni na portalu Hrčak: analiza radova koji su napisani na temelju diplomskih radova pohranjenih u repozitoriju Dabar

Cilj. Rad problematizira trend objavljivanja radova napisanih na temelju diplomskih radova, u znanstvenim časopisima u otvorenom pristupu. Objašnjen je doprinos repozitorija znanstvenih radova institucijskoj vidljivosti, kao i uloga knjižnice u oblikovanju repozitorija. U radu se analizira koliko je znanstvenih članaka proizašlo iz diplomskih radova studenata tri filozofska fakulteta te se utvrđuje učestalost pristupa i preuzimanja diplomskih i znanstvenih radova i njihovu citiranost. Istražuje se koliko je vremena potrebno da bi se diplomski rad pretvorio u članak i koje su prevladavajuće kategorizacije tih članaka. Pristup/metodologija/dizajn. Korišten je bibliometrijski pristup, uz metodu analize sadržaja koja je obuhvatila sljedeće pokazatelje: citiranost, zastupljenost znanstvenih radova po znanstvenim područjima, kategorizaciju radova, autorstvo, vrijeme objave, te broj pregleda i preuzimanja radova. Polazište za istraživanje bili su svi diplomski radovi pohranjeni u repozitoriju Dabar na tri usporediva filozofska fakulteta u Splitu, Rijeci i Osijeku u razdoblju od 2013. do 2020. godine, ukupno 2791 rad. Nakon povezivanja diplomskih radova sa proizašlim znanstvenim radovima objavljenim na portalu Hrčak testirane su razlike u citiranosti i vidljivosti radova u dva sustava. Rezultati. Istraživanje je pokazalo da se približno 6% diplomskih radova iz društvenog područja i 2% radova iz humanističkog područja preoblikuje u znanstvene članke objavljene u časopisima dostupnim u otvorenom pristupu na portalu Hrčak. Većina znanstvenih članaka objavi se do dvije godine nakon pohrane diplomskog rada u repozitoriju. Objavom radova u časopisima dostupnim na portalu Hrčak značajno se poboljšava njihova vidljivost. Potvrđena je i važnost otvorenog pristupa diplomskim radovima u sustavu Dabar. Ograničenja istraživanja odnose se prije svega na početni odabir radova iz područja društvenih i humanističkih znanosti. Praktična primjena. Na praktičnoj razini rad može poslužiti studentima i mentorima koji namjeravaju diplomske radove pretvoriti u članke, knjižničarima u pružanju podrške studentima, i urednicima probirnih časopisa kao analiza postojećeg stanja i polazište za odabir radova. Društveni značaj. Rad pruža uvid u broj i vrstu studentskih radova koji doprinose vidljivosti fakulteta i posredno sveučilišta. Originalnost/vrijednost. Prvi put je razmotrena i napravljena analiza studentskih radova koji su objavljeni na osnovi teme i istraživanja iz diplomskih radova

Studentski znanstveni radovi dostupni na portalu Hrčak: analiza radova koji su napisani na temelju diplomskih radova pohranjenih u repozitoriju Dabar

Cilj. Rad problematizira trend objavljivanja radova napisanih na temelju diplomskih radova, u znanstvenim časopisima u otvorenom pristupu. Objašnjen je doprinos repozitorija znanstvenih radova institucijskoj vidljivosti, kao i uloga knjižnice u oblikovanju repozitorija. U radu se analizira koliko je znanstvenih članaka proizašlo iz diplomskih radova studenata tri filozofska fakulteta te se utvrđuje učestalost pristupa i preuzimanja diplomskih i znanstvenih radova i njihovu citiranost. Istražuje se koliko je vremena potrebno da bi se diplomski rad pretvorio u članak i koje su prevladavajuće kategorizacije tih članaka. Pristup/metodologija/dizajn. Korišten je bibliometrijski pristup, uz metodu analize sadržaja koja je obuhvatila sljedeće pokazatelje: citiranost, zastupljenost znanstvenih radova po znanstvenim područjima, kategorizaciju radova, autorstvo, vrijeme objave, te broj pregleda i preuzimanja radova. Polazište za istraživanje bili su svi diplomski radovi pohranjeni u repozitoriju Dabar na tri usporediva filozofska fakulteta u Splitu, Rijeci i Osijeku u razdoblju od 2013. do 2020. godine, ukupno 2791 rad. Nakon povezivanja diplomskih radova sa proizašlim znanstvenim radovima objavljenim na portalu Hrčak testirane su razlike u citiranosti i vidljivosti radova u dva sustava. Rezultati. Istraživanje je pokazalo da se približno 6% diplomskih radova iz društvenog područja i 2% radova iz humanističkog područja preoblikuje u znanstvene članke objavljene u časopisima dostupnim u otvorenom pristupu na portalu Hrčak. Većina znanstvenih članaka objavi se do dvije godine nakon pohrane diplomskog rada u repozitoriju. Objavom radova u časopisima dostupnim na portalu Hrčak značajno se poboljšava njihova vidljivost. Potvrđena je i važnost otvorenog pristupa diplomskim radovima u sustavu Dabar. Ograničenja istraživanja odnose se prije svega na početni odabir radova iz područja društvenih i humanističkih znanosti. Praktična primjena. Na praktičnoj razini rad može poslužiti studentima i mentorima koji namjeravaju diplomske radove pretvoriti u članke, knjižničarima u pružanju podrške studentima, i urednicima probirnih časopisa kao analiza postojećeg stanja i polazište za odabir radova. Društveni značaj. Rad pruža uvid u broj i vrstu studentskih radova koji doprinose vidljivosti fakulteta i posredno sveučilišta. Originalnost/vrijednost. Prvi put je razmotrena i napravljena analiza studentskih radova koji su objavljeni na osnovi teme i istraživanja iz diplomskih radova

Race-free estimated glomerular filtration rate equation in kidney transplant recipients:development and validation study

OBJECTIVE: To compare the performance of a newly developed race-free kidney recipient specific glomerular filtration rate (GFR) equation with the three current main equations for measuring GFR in kidney transplant recipients.DESIGN: Development and validation study SETTING: 17 cohorts in Europe, the United States, and Australia (14 transplant centres, three clinical trials).PARTICIPANTS: 15 489 adults (3622 in development cohort (Necker, Saint Louis, and Toulouse hospitals, France), 11 867 in multiple external validation cohorts) who received kidney transplants between 1 January 2000 and 1 January 2021.MAIN OUTCOME MEASURE: The main outcome measure was GFR, measured according to local practice. Performance of the GFR equations was assessed using P 30 (proportion of estimated GFR (eGFR) within 30% of measured GFR (mGFR)) and correct classification (agreement between eGFR and mGFR according to GFR stages). The race-free equation, based on creatinine level, age, and sex, was developed using additive and multiplicative linear regressions, and its performance was compared with the three current main GFR equations: Modification of Diet in Renal Disease (MDRD) equation, Chronic Kidney Disease Epidemiology Collaboration (CKD-EPI) 2009 equation, and race-free CKD-EPI 2021 equation. RESULTS: The study included 15 489 participants, with 50 464 mGFR and eGFR values. The mean GFR was 53.18 mL/min/1.73m 2 (SD 17.23) in the development cohort and 55.90 mL/min/1.73m 2 (19.69) in the external validation cohorts. Among the current GFR equations, the race-free CKD-EPI 2021 equation showed the lowest performance compared with the MDRD and CKD-EPI 2009 equations. When race was included in the kidney recipient specific GFR equation, performance did not increase. The race-free kidney recipient specific GFR equation showed significantly improved performance compared with the race-free CKD-EPI 2021 equation and performed well in the external validation cohorts (P 30 ranging from 73.0% to 91.3%). The race-free kidney recipient specific GFR equation performed well in several subpopulations of kidney transplant recipients stratified by race (P 30 73.0-91.3%), sex (72.7-91.4%), age (70.3-92.0%), body mass index (64.5-100%), donor type (58.5-92.9%), donor age (68.3-94.3%), treatment (78.5-85.2%), creatinine level (72.8-91.3%), GFR measurement method (73.0-91.3%), and timing of GFR measurement post-transplant (72.9-95.5%). An online application was developed that estimates GFR based on recipient's creatinine level, age, and sex (https://transplant-prediction-system.shinyapps.io/eGFR_equation_KTX/). CONCLUSION: A new race-free kidney recipient specific GFR equation was developed and validated using multiple, large, international cohorts of kidney transplant recipients. The equation showed high accuracy and outperformed the race-free CKD-EPI 2021 equation that was developed in individuals with native kidneys.TRIAL REGISTRATION: ClinicalTrials.gov NCT05229939.</p

Histopathological features of time-zero kidney biopsy are predictive factors for posttransplant anemia

Posttransplant anemia is a common complication of kidney transplantation, associated with reduced graft survival and higher mortality. We aimed to determine the association of posttransplant anemia with histopathological characteristics of time-zero allograft biopsy and donor clinical characteristics. Methods We conducted a retrospective, observational cohort study that included 587 patients who underwent kidney transplantation in our Centre. Hemoglobin levels were assessed at 6 and 12 months after transplantation, and anemia was defined according to World Health Organization criteria. The kidney allograft time-zero biopsy has been done in all investigated cases. The evaluated histopathological parameters of the kidney allografts included glomerulosclerosis, arteriolar hyalinosis, vascular fibrous intimal thickening, interstitial fibrosis, tubular atrophy, and interstitial fibrosis and tubular atrophy. The Banff Classification of Allograft Pathology criteria were followed to assess the allograft histopathological changes. Results The prevalence of anemia was 31.3% at 6 months after transplantation and 23.5% at 12 months. There was an association between 20-50% glomerulosclerosis and posttransplant anemia in both time points, independently from eGFR. Arteriolar hyalinosis and interstitial fibrosis were identified as independent risk factors for anemia at 6 months after transplantation. Conclusion Histopathological features of time-zero kidney biopsy may be predictors of PTA. Among them, our study recognized 20-50% degree of glomerulosclerosis, AH, and CV as the most significant risk factors for PTA

An Exceptional Cause of Progressive Dyspnoea in a Renal Transplant Recipient: Hemangioma of the Mitral Valve

Primary cardiac hemangioma is a very rare benign vascular tumor, with valvular hemangiomas being even less frequent as valves are generally avascular structures. We present the first case of mitral valve hemangioma in a renal transplant recipient. Patient presented with progressive dyspnea. Transesophageal echocardiogram (TEE) demonstrated a 0.8x0.9-cm pedunculated tumor mass on the posterior leaflet of the mitral valve. Coronary angiography identified a small artery which filled from the circumflex artery and fed the tumor. The tumor was surgically removed. Histopathological examination revealed a hemangioma. The postoperative course was uneventful with stable graft function

Follow‐up of renal transplant recipients after acute COVID‐19 — A prospective cohort single‐center study

Introduction: Although most patients recover within several weeks after acute COVID-19, some of them develop long-lasting clinical symptoms. Renal transplant recipients have an increased mortality risk from COVID-19. We aimed to describe complications occurring after COVID-19 in this group of patients. ----- Methods: A prospective single-center cohort study was conducted at University Hospital Centre Zagreb. Patients with two negative reverse transcriptase-polymerase chain reaction (RT-PCR) tests for SARS-CoV-2 after COVID-19 were eligible for further follow-up at our outpatient clinic. They underwent detailed clinical and laboratory assessments. The primary outcome was the development of complications after COVID-19. ----- Results: Only 11.53% of renal transplant recipients who survived acute COVID-19 were symptomless and free from new-onset laboratory abnormalities during the median follow-up of 64 days (range: 50-76 days). Three patients died from sepsis after discharge from the hospital. In 47 patients (45.2%), clinical complications were present, while 74 patients (71.2%) had one or more laboratory abnormalities. The most common clinical complications included shortness of breath (19.2%), tiredness (11.5%), peripheral neuropathy (7.7%), self-reported cognitive impairments (5.7%), and dry cough (7.7%). Most common laboratory abnormalities included shortened activated partial thromboplastin time (50%), elevated D-dimers (36.5%), elevated fibrinogen (30.16%), and hypogammaglobulinemia (24%). Positive RT-PCR for cytomegalovirus (8.7%), Epstein-Barr virus (26%), or BK virus (16.3%). Multivariate analysis identified the history of diabetes mellitus and eGFR CKD-EPI as predictors for the development of post-COVID clinical complications. Six months after acute COVID-19, elevated D-dimers persisted with normalization of other laboratory parameters. Twenty-nine patients were hospitalized, mostly with several concomitant problems. However, initially reported clinical problems gradually improved in the majority of patients. ----- Conclusion: Post-COVID-19 clinical and laboratory complications are frequent in the renal transplant population, in some of them associated with significant morbidity. All patients recovered from acute COVID-19 should undergo long-term monitoring for evaluation and treatment of complications