Correlation Between Social Supports and Drug Abuse Screening Test-10 Among Senior High School Students

Drug abuse is common among adolescent, and its consequences pose important public health problem. Family, friend, school and other member of community should give support to adolescents so that they are emotionally and mentally ready to fight against drug. This cross sectional study was designed to investigate correlation between social support with Drug Abuse Screening Test-10 (DAST-10) and association of social support with treatment evaluation. Subjects included 210 senior high school students in Pekanbaru, Riau. Data obtained from Adolescents Social Support (ASS) questionnaire included social supports, and from DAST-10 included severity and treatment evaluation of drug abuse. This study showed family support, school environment and peer group support were significantly associated and significantly correlation to DAST-10 with strong correlation (0.718, 0.720 and 0.727, respectively) in negative direction. In conclusion, social supports could be a protective factor for adolescents related drug abuse.Key words: social support, DAST-10, drug abuse, senior high school studen

Pola Kuman dan Uji Kepekaan Antibiotik pada Pasien Unit Perawatan Intensif Anak di Rumah Sakit Umum Daerah Koja, Jakarta

Latar belakang. Pasien di unit perawatan intensif (UPI) anak (pediatric intensive care unit/PICU) merupakan pasien dengan penyakit kritis sehingga sebagian besar pasien menggunakan antibiotik. Profil resistensi bakteri akan membantu untuk pemilihan terapi empirik yang akan digunakan pada suatu unit. Tujuan. Untuk mendapatkan profil bakteri di PICU RSUD Koja berdasarkan hasil kultur, Metode. Hasil kultur yang dilakukan pada seluruh pasien yang masuk ke PICU pada periode Mei 2015 – April 2016 pada hari kerja pertama dikumpulkan dari departemen patologi klinik RSUD Koja Hasil. Didapatkan 486 hasil kultur, 410 di antaranya tidak menunjukkan pertumbuhan kuman. Hasil positif terdapat pada 64 bakteri Gram-positif dan 12 Gram-negatif. Bakteri Gram positif terbanyak ditemukan adalah Staphylococcus hominis (19), Staphylococcus epidermidis (18), Staphylococcus haemolyticus (13), dan Staphylococcus aureus (9). Sementara itu, bakteri Gram negatif terbanyak ditemukan adalah Salmomella typhi (6) dan Acinetobacter baumanii (2). Pada kelompok bakteri Gram positif, antibiotik yang paling sensitif adalah vancomisin (95,2%), gentamisin (68,3%), cotrimoxazole (44,4%), cefotaxime (31,7%), dan ceftriaxone (31,7%). Pada kelompok bakteri Gram negatif, antibiotik yang paling sensitif adalah meropenem (84,6%), cotrimoxazole (84,6%), amikasin (61,5%), gentamisin (53,8%), and cefepime (46,2%). Kesimpulan. Vankomisin merupakan antibiotik yang paling poten untuk digunakan. Cefotaxime dan gentamicin kami pilih untuk digunakan sebagai antibiotik empirik di unit kami, dengan meropenem sebagai lini berikutnya. Vankomisin kami gunakan hanya pada kasus khusus

Metabolic syndrome and Framingham risk score in obese young adults

<p style="text-align: justify;"><strong>Background</strong>: The increase number of the metabolic syndrome (MetS) among young adults was mostly caused by obesity. MetS increases the risk of coronary heart disease (CHD) which can be estimated by Framingham risk score (FRS). The study was aimed to know the prevalence of MetS and FRS in obese young adults and to associate them with the components of MetS.<br /> <strong></strong></p><p style="text-align: justify;"><strong>Methods:</strong> A total of 70 male and female students aged 18 to 25 years with BMI ≥ 25 kg/m² in Faculty of Medicine Universitas Indonesia were selected consecutively. The blood samples used to test fasting blood glucose, total cholesterol, high-density lipoprotein, and triglyceride were examined in Department of Clinical Pathology, Cipto Mangunkusumo Hospital after fasting for 14 to 16 hours. International Diabetes Federation (IDF) definition was used to diagnose MetS. Univariate and bivariate analysis were done.<br /> <strong></strong></p><p style="text-align: justify;"><strong>Results: </strong>The prevalence of MetS based on IDF definition was 18.6% among obese young adults. The most associated MetS components was hypertriglyceridemia (OR 12.13; 95% CI 2.92-50.46; p = 0.001), followed with high blood pressure (OR 9.33; 95% CI 2.26-38.56; p = 0.001), low-HDL (OR 8.33; 95% CI 2.17-32.05; p = 0.003), and impaired fasting glucose (p = 0.03). Four subjects had FRS ≥ 1% and 66 subjects had risk &lt; 1%. Increased FRS was not associated with MetS (p = 0.154). There was no component of MetS associated with increased FRS.<br /> <strong></strong></p><p style="text-align: justify;"><strong>Conclusion:</strong> Prevalence of MetS in obese young adults was similar with obese children and adolescents. Although no association of MetS and FRS was found, they are significant predictors for CHD which should not be used separately.<em> <strong>(Med J Indones. 2013;22:100-6)</strong></em></p><p style="text-align: justify;"><strong>Keywords:</strong> <em>Abdominal obesity, Framingham risk score, metabolic syndrome, young adults</em></p

Effects of an additional small group discussion to cognitive achievement and retention in basic principles of bioethics teaching methods

<p><strong>Aim</strong> The place of ethics in undergraduate medical curricula is essential but the methods of teaching medical ethics did not show substantial changes. “Basic principles of bioethics” is the best knowledge to develop student’s reasoning analysis in medical ethics In this study, we investigate the effects of an additional small group discussion in basic principles of bioethics conventional lecture methods to cognitive achievement and retention. This study was a randomized controlled trial with parallel design. Cognitive scores of the basic principles of bioethics as a parameter was measured using basic principles of bioethics (Kaidah Dasar Bioetika, KDB) test. Both groups were attending conventional lectures, then the intervention group got an additional small group discussion.</p><p><strong>Result</strong> Conventional lectures with or without small group discussion significantly increased cognitive achievement of basic principles of bioethics (P= 0.001 and P= 0.000, respectively), and there were significant differences in cognitive achievement and retention between the 2 groups (P= 0.000 and P= 0.000, respectively).</p><p><strong>Conclusion</strong> Additional small group discussion method improved cognitive achievement and retention of basic principles of bioethics. <em><strong>(Med J Indones 2009; 18: 48-52)</strong></em></p><p><strong>Keywords:</strong> <em>lecture, specification checklist, multiple choice questions</em></p

Association between dietary intake of vitamin A, C, and E as antioxidants and cognitive function in the elderly at a nursing home

<p>As oxidative stress is considered one of the major mechanisms underlying degenerative changes, antioxidants from dietary sources, such as vitamin A, C, and E, may have protective effects against oxidative stress and thus be able to prevent or delay cognitive impairment in the elderly. This cross sectional study was designed to determine the association between dietary intake of vitamin A, C, and E and the presence of cognitive impairment in the elderly, along with other factors. Subjects included 36 residents from a nursing home in Jakarta, Indonesia. The data obtained including daily nutrition intake values one week prior to sampling converted from semi- quantitative food frequency questionnaire (SFFQ) results, Mini Mental State Examination (MMSE) scores, and anthropometrical measurement results. This study showed that while sex, age, education, nutritional status, and macronutrients intake were not significantly associated with presence of cognitive impairment, significant positive correlation existed between education and MMSE score (p=0.036, r=0.351). Higher vitamin A and vitamin C intake were shown to be significantly associated with lower incidence of cognitive impairment (p=0.022 and p=0.045, respectively). Moreover, vitamin C was shown to have significant positive correlation with MMSE score (p=0.031, r=0.359). However, the association between vitamin E and the presence of impairment was not significant (p=0.129). Higher intake of vitamin A and C may delay or prevent cognitive impairment in the elderly. Higher intake of vitamin C may contribute to better cognitive functioning. The findings may be explained by the two antioxidant vitamins’ protective effects against neurode generative processes cause by oxidative stress. <em><strong>(Med J Indones 2007; 16:261-6)</strong></em></p><p><strong><em>Keywords:</em></strong> <em>antioxidant, vitamin A, vitamin C, vitamin E, cognitive impairment, the elderly</em></p

Cardiomyocyte-Restricted Expression of IL11 Causes Cardiac Fibrosis, Inflammation, and Dysfunction

Cardiac fibrosis is a common pathological process in heart disease, representing a therapeutic target. Transforming growth factor β (TGFβ) is the canonical driver of cardiac fibrosis and was recently shown to be dependent on interleukin 11 (IL11) for its profibrotic effects in fibroblasts. In the opposite direction, recombinant human IL11 has been reported as anti-fibrotic and anti-inflammatory in the mouse heart. In this study, we determined the effects of IL11 expression in cardiomyocytes on cardiac pathobiology and function. We used the Cre-loxP system to generate a tamoxifen-inducible mouse with cardiomyocyte-restricted murine Il11 expression. Using protein assays, bulk RNA-sequencing, and in vivo imaging, we analyzed the effects of IL11 on myocardial fibrosis, inflammation, and cardiac function, challenging previous reports suggesting the cardioprotective potential of IL11. TGFβ stimulation of cardiomyocytes caused Il11 upregulation. Compared to wild-type controls, Il11-expressing hearts demonstrated severe cardiac fibrosis and inflammation that was associated with the upregulation of cytokines, chemokines, complement factors, and increased inflammatory cells. IL11 expression also activated a program of endothelial-to-mesenchymal transition and resulted in left ventricular dysfunction. Our data define species-matched IL11 as strongly profibrotic and proinflammatory when secreted from cardiomyocytes and further establish IL11 as a disease factor