Changes in technique of handspring double salto forward tucked performed on horse and vaulting table

Aim of the research was to determine changes in technique parameters while performing handspring double salto forward tucked (Roche) on old horse and new vaulting table. On a sample of 9 vaults performed in 2000 World Cup in Ljubljana on horse and 9 vaults performed at World championship in Debrecen on vaulting table we made a series of t-tests for biomechanics kinematics parameters. There are differences in many variables, but most important are those related to the support phase (position of hands, take off vertical velocity) which also causes better outcome during the flight and landing. New vaulting table is really much better apparatus than the horse as has better place for support, which makes easier production of angular momentum (inclined table) and higher vertical take off velocity

KINEMATIC ANALYSIS OF SOME BACKWARD ACROBATIC JUMPS

The aim of our investigation was to determine kinematic parameters of some acrobatic jumps backward, related to the difficulty categories in the current men's FIG Code of points. Ten male gymnasts performed ten different acrobatic jumps backward during the European championship in 1996 in Koebenhaven (Denmark). The analyzed elements were stretched salto backward, stretched salto backward with 1/1 turn, stretched salto backward with 3/2 turn, stretched salto backward with 2/1 turn, double salto backward tucked, double salto backward tucked with 1/1 turn, double salto backward tucked with 2/1 turn, double salto backward stretched, double salto backward stretched with 1/1 turn and triple salto backward tucked. According to the results we can not define the difficulty categories, but the data are quite informative for further investigations, comparison with other similar types of sports and also for coaches for methodic purposes

DNA polymorphisms predict time to progression from uncomplicated to complicated Crohn's disease

OBJECTIVE: Most patients with Crohn's disease (CD) are diagnosed with the uncomplicated inflammatory form of the disease (Montreal stage B1). However, the majority of them will progress to complicated stricturing (B2) and penetrating (B3) CD during their lifetimes. The aim of our study was to identify the genetic factors associated with time to progression from uncomplicated to complicated CD. PATIENTS AND METHODS: Patients with an inflammatory phenotype at diagnosis were followed up for 10 years. Genotyping was carried out using Illumina ImmunoChip. After quality control, association analyses, Bonferroni's adjustments, linear and Cox's regression, and Kaplan-Meier analysis were carried out for 111 patients and Manhattan plots were constructed. RESULTS: Ten years after diagnosis, 39.1% of the patients still had the inflammatory form and 60.9% progressed to complicated disease, with an average time to progression of 5.91 years. Ileal and ileocolonic locations were associated with the complicated CD (P=1.08E-03). We found that patients with the AA genotype at single-nucleotide polymorphism rs16857259 near the gene CACNA1E progressed to the complicated form later (8.80 years) compared with patients with the AC (5.11 years) or CC (2.00 years) genotypes (P=3.82E-07). In addition, nine single-nucleotide polymorphisms (near the genes RASGRP1, SULF2, XPO1, ZBTB44, HLA DOA/BRD2, HLA DRB1/HLA DQA1, PPARA, PUDP, and KIAA1614) showed a suggestive association with disease progression (P<10). Multivariate Cox's regression analysis on the basis of clinical and genetic data confirmed the association of the selected model with disease progression (P=5.73E-16). CONCLUSION: Our study confirmed the association between the locus on chromosome 1 near the gene CACNA1E with time to progression from inflammatory to stricturing or penetrating CD. Predicting the time to progression is useful to the clinician in terms of individualizing patients' management

Dendritic cell profiles in the inflamed colonic mucosa predict the responses to tumor necrosis factor alpha inhibitors in inflammatory bowel disease

Dendritic cells play crucial roles in the control of inflammation and immune tolerance in the gut. We aimed to investigate the effects of tumor necrosis factor alpha (TNFa) inhibitors on intestinal dendritic cells in patients with inflammatory bowel disease and the potential role of intestinal dendritic cells in predicting the response to treatment

Genetic polymorphism in ATG16L1 gene influences the response to adalimumab in Crohn's disease patients

Aim: To see if SNPs could help predict response to biological therapy using adalimumab (ADA) in Crohn's disease (CD). Materials & methods: IBDQ index and CRP levels were used to monitor therapy response. We genotyped 31 CD-associated genes in 102 Slovenian CD patients. Results: The strongest association for treatment response defined as decrease in CRP levels was found for ATG16L1 SNP rs10210302. Additional SNPs in 7 out of 31 tested CD-associated genes (PTGER4, CASP9, IL27, C11orf30, CCNY, IL13, NR1I2) showed suggestive association with ADA response. Conclusion: Our results suggest ADA response in CD patients is genetically predisposed by SNPs in CD risk genes and suggest ATG16L1 as most promising candidate gene for drug response in ADA treatment. Original submitted 24 September 2014; Revision submitted 1 December 201