Is Auger-free luminescence present in CeF₃?

It is well known that Auger-free luminescence (AFL) is observable when the condition E-g>E-vc is satisfied, where E-g is the band-gap energy between the lowest unoccupied band and the highest occupied band and E-vc the energy difference between the top of the highest occupied band and the top of the next lower occupied band. From measurements of reflection and X-ray photoelectron spectra, CeF₃ is demonstrated to really satisfy this condition. No evidence for AFL is found, nevertheless. The absence of AFL in CeF₃ is related to a characteristic nature of its highest and next lower occupied bands, which are quite different from those of previously studied AFL-materials.ArticleJOURNAL OF LUMINESCENCE. 129(9):984-987 (2009)journal articl

Spectroscopic Observations of the Outflowing Wind in the Lensed Quasar SDSS J1001+5027

We performed spectroscopic observations of the small-separation lensed quasar SDSS J1001+5027, whose images have an angular separation $\theta \sim 2.^{\!\!\prime\prime}86$, and placed constraints on the physical properties of gas clouds in the vicinity of the quasar (i.e., in the outflowing wind launched from the accretion disk). The two cylinders of sight to the two lensed images go through the same region of the outflowing wind and they become fully separated with no overlap at a very large distance from the source ($\sim 330$ pc). We discovered a clear difference in the profile of the CIV broad absorption line (BAL) detected in the two lensed images in two observing epochs. Because the kinematic components in the BAL profile do not vary in concert, the observed variations cannot be reproduced by a simple change of ionization state. If the variability is due to gas motion around the background source (i.e., the continuum source), the corresponding rotational velocity is $v_{rot}\geq 18,000$ km/s, and their distance from the source is $r\leq 0.06$ pc assuming Keplerian motion. Among three MgII and three CIV NAL systems that we detected in the spectra, only the MgII system at $z_{abs} = 0.8716$ shows a hint of variability in its MgI profile on a rest-frame time scale of $\Delta t_{rest}$ $\leq 191$ days and an obvious velocity shear between the sightlines whose physical separation is $\sim 7$ kpc. We interpret this as the result of motion of a cosmologically intervening absorber, perhaps located in a foreground galaxy.Comment: 15 pages, including 7 figures; accepted for publication in the Astrophysical Journa

Non-Equilibrium Ionization States of GRB Environments

Iron spectral features are thought to be the best tracer of a progenitor of gamma-ray bursts (GRBs). The detections of spectral features such as an iron line and/or a Radiative Recombination edge and Continuum (RRC) were reported in four X-ray afterglows of GRBs. However their properties were different each other burst by burst. For example, Chandra observation of GRB 991216 reported both the strong H-like iron line together with its RRC. On the contrary, Yoshida et al. (2001) report only a detection of the strong RRC in GRB 970828 with ASCA. Since it is difficult to produce the strong RRC, we have to consider special condition for the line and/or the RRC forming region. In this paper, we point out a possibility of a ``non-equilibrium ionization state'' for the line and the RRC forming region.Comment: 10pages, 2figures. Accepted for ApJL. This is a companion paper by A.Yoshida et. a

Large-cell neuroendocrine carcinoma of lung with epidermal growth factor receptor (EGFR) gene mutation and co-expression of adenocarcinoma markers: a case report and review of the literature

PURPOSE: A high rate of response to treatment with epidermal growth factor receptor tyrosine kinase inhibitor (EGFR-TKI) has been observed in certain patients (women, of East Asian ethnicity, with non-smoking history and adenocarcinoma histology) with mutations in exons 18 to 21 of the tyrosine kinase domain of EGFR. Some cases of high-grade neuroendocrine carcinoma of the lung harboring mutations have been sporadically reported. METHODS: We describe the case of a 78-year-old woman with large-cell neuroendocrine carcinoma of the lung, with mutation in exon 21 L858R and co-expression of adenocarcinoma markers. RESULTS: A mass (3.0 cm in diameter) was identified in the inferior lobe of the left lung, accompanied by metastases into ipsilateral mediastinal lymph nodes and elevations of serum pro-gastrin-releasing peptide and carcinoembryonic antigen. Initial transbronchial brushing cytology suggested high-grade neuroendocrine carcinoma favoring small-cell carcinoma in poorly smeared and degenerated preparations, and revealed exon 21 L858R mutation. Re-enlargement of the cancer and bone metastases was observed after chemotherapy, and further testing suggested large-cell neuroendocrine carcinoma with immunoreactivity to markers of primary lung adenocarcinoma and L858R mutation. High-grade neuroendocrine carcinoma with mutations in the tyrosine kinase domain of EGFR may be associated with adenocarcinoma, as reviewed from the literature and may also apply to our case. CONCLUSIONS: EGFR-TKI could provide better quality of life and survival in patients with advanced or relapsed high-grade neuroendocrine carcinoma with EGFR gene mutations. Further studies in this respect are warranted

Combined replacement effects of human modified β-hexosaminidase B and GM2 activator protein on GM2 gangliosidoses fibroblasts

AbstractGM2 gangliosidoses are autosomal recessive lysosomal storage diseases (LSDs) caused by mutations in the HEXA, HEXB and GM2A genes, which encode the human lysosomal β-hexosaminidase (Hex) α- and β-subunits, and GM2 activator protein (GM2A), respectively. These diseases are associated with excessive accumulation of GM2 ganglioside (GM2) in the brains of patients with neurological symptoms. Here we established a CHO cell line overexpressing human GM2A, and purified GM2A from the conditioned medium, which was taken up by fibroblasts derived from a patient with GM2A deficiency, and had the therapeutic effects of reducing the GM2 accumulated in fibroblasts when added to the culture medium. We also demonstrated for the first time that recombinant GM2A could enhance the replacement effect of human modified HexB (modB) with GM2-degrading activity, which is composed of homodimeric altered β-subunits containing a partial amino acid sequence of the α-subunit, including the GSEP loop necessary for binding to GM2A, on reduction of the GM2 accumulated in fibroblasts derived from a patient with Tay-Sachs disease, a HexA (αβ heterodimer) deficiency, caused by HEXA mutations. We predicted the same manner of binding of GM2A to the GSEP loop located in the modified HexB β-subunit to that in the native HexA α-subunit on the basis of the x-ray crystal structures. These findings suggest the effectiveness of combinational replacement therapy involving the human modified HexB and GM2A for GM2 gangliosidoses

Structural mechanism and photoprotective function of water-soluble chlorophyll-binding protein

This research was originally published in Journal of Biological Chemistry. Daisuke Horigome, Hiroyuki Satoh, Nobue Itoh, Katsuyoshi Mitsunaga, Isao Oonishi, Atsushi Nakagawa and Akira Uchida. Structural mechanism and photoprotective function of water-soluble chlorophyll-binding protein. Journal of Biological Chemistry. 2007; 282, 6525-6531. © the American Society for Biochemistry and Molecular Biology