An International Comparison of the TFP Levels and the Productivity Convergence of Japanese, Korean, Taiwanese, and Chinese Listed Firms (Extended Version)

Focusing on Japanese, Korean, Taiwanese, and Chinese firms in the manufacturing sector, this paper examines productivity catch-up at the firm level using the distance from the technology frontier as a direct measure of the potential for catch-up. We also examine the role of absorptive capacity for technological catch-up by including variables such as R&D expenditure and foreign ownership in our empirical estimation. We find that the national frontier has a stronger pull on domestic firms than the regional frontier, which is in line with findings by Bartelsman, Haskel and Martin (2008). This result indicates that policies to raise the technology level of national frontier firms are beneficial for all firms in that country.productivity, catch-up, absorptive capacity

An International Comparison of the TFP Levels and the Productivity Convergence of Japanese, Korean, Taiwanese and Chinese Listed Firms

In this paper, we analyzed productivity catching up at the firm level in the Japanese, Korean, Taiwanese and Chinese manufacturing sector using the distance from the global technological frontier as a direct measure of the potential for technological frontier. We also examined the role of the absorption capacity for the technological catch-up by including the variables, such as R&D expenditure and foreign ownership in our empirical estimation model. Our main results can be summarized as follows. First, although Japanese firms enjoy the highest average TFP level in many industries, their TFP growth rate has been relatively low during the past two decades. Taiwanese and Korean firms have achieved considerably high TFP growth in certain industries, and the some firms in the industries almost caught up or exceeded the Japanese firms' TFP level. The average TFP level of Chinese firms is still much lower than that of Japanese, Korean and Taiwanese firms in many industries. Second, in Korea, the TFP levels of low-performing firms are approaching those of the national frontier firms at a more rapid pace than in other countries. In addition, Korean firms try to catch up the global frontier once they reached to the national frontier level TFP. Chinese firms are very slow in catching up and the only engine of the knowledge creation is firms located in the trade-oriented coast. Third, in the all four countries, the speed of the convergence of the firms far from the national frontier is faster than the firms near the frontier.

Information and Export Decisions: Bank’s Role as a Conduit of Information

This paper examines how firms’ decision to start exporting is affected by the availability of information on export markets. Unlike existing studies which focus on information sharing among firms, we are interested in the information provided by firms’ main bank. Specifically, using a unique dataset containing information on both Japanese firms’ export activities and their main banks’ experience in transacting with other exporting firms, we examine whether main banks act as a conduit of information on export markets. We find that information spillovers through main banks positively affect client firms’ decision to start exporting (extensive margin), implying that information on foreign markets provided by banks substantially reduces the fixed entry cost of exporting. On the other hand, we do not find any evidence that information provided by banks has an effect on the export volume or on the growth rate of exports (intensive margin). Our results highlight that channels of information spillovers other than those examined in the literature so far may be of considerable importance

Head-Related Transfer Function Interpolation from Spatially Sparse Measurements Using Autoencoder with Source Position Conditioning

We propose a method of head-related transfer function (HRTF) interpolation from sparsely measured HRTFs using an autoencoder with source position conditioning. The proposed method is drawn from an analogy between an HRTF interpolation method based on regularized linear regression (RLR) and an autoencoder. Through this analogy, we found the key feature of the RLR-based method that HRTFs are decomposed into source-position-dependent and source-position-independent factors. On the basis of this finding, we design the encoder and decoder so that their weights and biases are generated from source positions. Furthermore, we introduce an aggregation module that reduces the dependence of latent variables on source position for obtaining a source-position-independent representation of each subject. Numerical experiments show that the proposed method can work well for unseen subjects and achieve an interpolation performance with only one-eighth measurements comparable to that of the RLR-based method.Comment: Accepted to International Workshop on Acoustic Signal Enhancement (IWAENC) 202

Japanese Encephalitis Virus in Meningitis Patients, Japan

Cerebrospinal fluid specimens from 57 patients diagnosed with meningitis were tested for Japanese encephalitis virus. Total RNA was extracted from the specimens and amplified. Two products had highest homology with Nakayama strain and 2 with Ishikawa strain. Results suggest that Japanese encephalitis virus causes some aseptic meningitis in Japan

Gastric Carcinoid with Hypergastrinemia: Report of Three Cases

We report 3 cases of gastric carcinoids with hypergastrinemia. Case 1: A 60-year-old man had a 2 cm carcinoid of the stomach and underwent partial resection. Involvement of the muscularis propria and lymph nodes metastasis were observed microscopically. Follow-up gastroscopy revealed another carcinoid lesion and total gastrectomy was performed. Case 2: A 67-year-old woman with multiple carcinoids of the entire stomach underwent antrectomy. No growth of residual tumors has been detected so far. Case 3: A 61-year-old man had a tumor near the esophagogastric junction and underwent total gastrectomy. Carcinoid component was diffusely intermingled with adenocarcinoma in the tumor and invaded into the subserosa. In all 3 cases, the serum gastrin level was high and atrophic gastritis was microscopically observed. Carcinoid tumor in Case 3 was different from those in Cases 1 and 2 and interestingly, gastric carcinoid with hypergastrinemia showed various types of appearance

Reactions of 2-methylchromones with cyanoacetamides and ethyl cyanoacetate. synthesis of 6-(2-hydroxyaryl)-4-methyl-2-oxo-1,2-dihydropyridine-3- carbonitriles and 7-hydroxy-6-imino-9-methyl-6h-benzo[c]chromene-8-carbonitriles

Although 2-methylchromones react with cyanoacetamide and N-methyl cyanoacetamide in the presence of sodium ethoxide in refluxing ethanol to produce 6-(2-hydroxyaryl)-4-methyl-2-oxo-1,2-dihydropyridine-3-carbonitriles, their reactions with ethyl cyanoacetate under the same conditions took an entirely different course and gave 7-hydroxy-6-imino-9-methyl-6H-benzo[c] chromene-8-carbonitriles. © 2013 HeteroCorporation

Midkine promoter-based conditionally replicative adenovirus therapy for midkine-expressing human pancreatic cancer

<p>Abstract</p> <p>Background</p> <p>To develop a novel therapeutic strategy for human pancreatic cancer using a midkine promoter-based conditionally replicating adenovirus.</p> <p>Methods</p> <p>We examined midkine mRNA expression and midkine protein expression by seven human pancreatic cancer cell lines (AsPC-1, BxPC-3, CFPAC-1, HPAC, MIAPaCa-2, PANC-1, and Suit-2), as well as by non-cancerous pancreatic tissue and pancreatic cancers. Midkine promoter activity was measured in cancer cell lines by the dual luciferase reporter assay. Adenoviral transduction efficiency was assessed by fluorescent staining of cancer cell lines using adenovirus type 5 containing the green fluorescent protein gene (Ad5GFP). Replication of adenovirus type 5 containing the 0.6 kb midkne promoter (Ad5MK) was assessed by the detection of E1 protein in cancer cell lines. The cytotoxicity of Ad5MK for cancer cells was evaluated from the extent of growth inhibition after viral infection. Infection and replication were also assessed in nude mice with subcutaneous Suit-2 tumors by intratumoral injection of Ad5MK, Ad5GFP, or vehicle. E1a mRNA expression in the treated tumors and expression of the replication-specific adenoviral hexon protein were evaluated. Finally, the anti-tumor activity of Ad5MK against intraperitoneal xenografts of Suit-2 pancreatic cancer cells was examined after intraperitoneal injection of the virus.</p> <p>Results</p> <p>Both midkine mRNA expression and midkine protein expression were strong in AsPC-1 and CFPAC-1 cell liens, moderate in BxPC-3, HPAC, and Suit-2 cell lines, and weak in PANC-1 and MIAPaCa-2 cell lines. Expression of midkine mRNA was significantly stronger in pancreatic cancers than in non-cancerous pancreatic tissues. The relative luciferase activity mediated by the 0.6 kb midkne fragment in AsPC-1, PANC-1, and Suit-2 cell lines was approximately 6 to 20 times greater than that in midkne-negative MIAPaCa-2 cell lines. Pancreatic cancer cell lines exhibited a heterogeneous adenoviral transduction profile. E1A expression was higher in cell lines with strong midkine expression than in cell lines with weak midkine expression. Ad5MK showed much greater cytotoxicity for midkine-expressing Suit-2 and PANC-1 cell lines than for midkine-negative MIAPaCa-2 cell lines. In the Suit-2 subcutaneous xenograft model, expression of E1A was detected in Ad5MK-treated tumors, but not in untreated and Ad5GFP-treated tumors. In the Suit-2 intraperitoneal xenograft model, the Ad5MK group survived for significantly longer than the Ad5GFP, PBS, and untreated groups.</p> <p>Conclusion</p> <p>Ad5MK has an anti-tumor effect against human pancreatic cancer cell lines that express midkine mRNA. Midkine promoter-based conditionally replicative adenovirus might be a promising new gene therapy for pancreatic cancer.</p