1,250 research outputs found
An Exact Solution of BPS Domain Wall Junction
An exact solution of domain wall junction is obtained in a four-dimensional
N=1 supersymmetric U(1) X U(1)' gauge theory with three pairs of chiral
superfields which is motivated by the N=2 SU(2) gauge theory with one flavor
perturbed by an adjoint scalar mass. The solution allows us to evaluate various
quantities including a new central charge Y_k associated with the junction
besides Z_k which appears already in domain walls. We find that the new central
charge Y_k gives a negative contribution to the mass of the domain wall
junction whereas the central charge Z_k gives a dominant positive contribution.
One has to be cautious to identify the central charge Y_k alone as the mass of
the junction.Comment: LaTeX file, 13 page, 1 ps figur
The expanding territories of condensin II.
This is the author accepted manuscript. The final version is available from Taylor & Francis via http://dx.doi.org/10.1080/15384101.2015.106335
Audio Signal Enhancement with Learning from Positive and Unlabelled Data
Supervised learning is a mainstream approach to audio signal enhancement (SE)
and requires parallel training data consisting of both noisy signals and the
corresponding clean signals. Such data can only be synthesised and are
mismatched with real data, which can result in poor performance on real data.
Moreover, clean signals may be inaccessible in certain scenarios, which renders
this conventional approach infeasible. Here we explore SE using non-parallel
training data consisting of noisy signals and noise, which can be easily
recorded. We define the positive (P) and the negative (N) classes as signal
inactivity and activity, respectively. We observe that the spectrogram patches
of noise clips can be used as P data and those of noisy signal clips as
unlabelled data. Thus, learning from positive and unlabelled data enables a
convolutional neural network to learn to classify each spectrogram patch as P
or N to enable SE.Comment: Accepted to ICASSP202
The Biogeography of Green Algae Associated with Red Snow in Japan
第3回極域科学シンポジウム/第34回極域生物シンポジウム 11月27日(火) 国立極地研究所 3階ラウン
Roles of the WHHL Rabbit in Translational Research on Hypercholesterolemia and Cardiovascular Diseases
Conquering cardiovascular diseases is one of the most important problems in human health. To overcome cardiovascular diseases, animal models have played important roles. Although the prevalence of genetically modified animals, particularly mice and rats, has contributed greatly to biomedical research, not all human diseases can be investigated in this way. In the study of cardiovascular diseases, mice and rats are inappropriate because of marked differences in lipoprotein metabolism, pathophysiological findings of atherosclerosis, and cardiac function. On the other hand, since lipoprotein metabolism and atherosclerotic lesions in rabbits closely resemble those in humans, several useful animal models for these diseases have been developed in rabbits. One of the most famous of these is the Watanabe heritable hyperlipidemic (WHHL) rabbit, which develops hypercholesterolemia and atherosclerosis spontaneously due to genetic and functional deficiencies of the low-density lipoprotein (LDL) receptor. The WHHL rabbit has been improved to develop myocardial infarction, and the new strain was designated the myocardial infarction-prone WHHL (WHHLMI) rabbit. This review summarizes the importance of selecting animal species for translational research in biomedical science, the development of WHHL and WHHLMI rabbits, their application to the development of hypocholesterolemic and/or antiatherosclerotic drugs, and future prospects regarding WHHL and WHHLMI rabbits
Effective treatment of a 13-year-old boy with steroid-dependent ocular myasthenia gravis using tacrolimus
Over the past several years, tacrolimus has attracted attention as a new therapeutic drug for myasthenia gravis (MG), but few reports have considered its use for MG in pediatric patients, and most of these have focused on severe systemic MG. In this case report, we used tacrolimus to successfully treat a 13-year-old boy with ocular MG who had suffered from severe steroid complications, including a failure of thrive and osteoporosis. He first showed symptoms of ocular MG at age 2 years 3 months. At age 13 years, he was receiving PSL (3.75 mg/day), but the symptoms of ocular MG recurred. We increased the dosage of oral PSL up to 30 mg/day, and three courses of mPSL pulse therapy were applied, but these therapies had only limited effect, and his symptoms worsened. Tacrolimus was started at 0.4mg/day (0.011mg/kg/day), and every two weeks the dose was gradually increased by 0.2mg/day. His symptoms of MG began to improve three weeks after the initial administration of tacrolimus. Approximately three months after the start of tacrolimus administration, PSL was discontinued. Currently, at one year and four months after the start of tacrolimus administration, while slight ptosis is observed in the evening, it does not influence his daily life, and his condition remains comparable to that when he stopped taking PSL. No adverse effects of tacrolimus have been recognized. In pediatric patients with steroid-dependent ocular MG without thymectomy, tacrolimus may be a safe and effective alternative to steroid and thymectomy
A case of mediastinal goiter treated surgically using a clavicle-lifting technique
AbstractIntroductionMediastinal goiter is a benign disease, which is defined as a goiter with the greater portion of its mass lying below the thoracic inlet. It is controversial whether the cervical approach is the best approach for all mediastinal goiter surgeries.Case presentationA 71-year-old woman presented with respiratory discomfort during exertion. Computed tomography (CT) revealed a mediastinal goiter extending to the arch of the aorta. Surgical resection was performed using a clavicle-lifting technique. The excised specimen was 13×10×5cm in size and weighed 220g. The pathological diagnosis was nodular goiter.DiscussionThe clavicle-lifting technique is a simple and safe technique that involves lifting the clavicles with a pediatric extension retractor (Kent Retractor Set, Takasago Medical Industry, Tokyo, Japan). This is a good choice for surgery on upper mediastinal lesions such as mediastinal goiters as it obviates the need for a median sternotomy.ConclusionAlthough further study is necessary, it appears that a transcervical approach using the clavicle-lifting technique may be an acceptable treatment for mediastinal goiters that extend to the aortic arch
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