Upravljanje sustavom za poboljšanje kvalitete električne energije u vremenskom području

The present paper describes a solution for Power Quality Conditioning using the DC/AC converter of a system developed for utilising renewable and waste energy sources. The algorithm of the Power Quality Conditioning (PQC) function of the system is based on the application of Space Vector theory and the system development relied on extensive use of computer simulation techniques.Članak prikazuje rješenje sustava za poboljšanje kvalitete električne energije uporabom izmjenjivača iz sustava razvijenog za korištenje obnovljivih i otpadnih izvora energije. Algoritam upravljanja sustavom za poboljšanje kvalitete električne energije utemeljen je na primjeni teorije vektorskog prostora, a razvoj cijelog sustava počivao je na sveobuhvatnoj primjeni računalnih simulacijskih tehnika

Cosmological Three-Point Function: Testing The Halo Model Against Simulations

We perform detailed comparison of the semi-analytic halo model predictions with measurements in numerical simulations of the two and three point correlation functions (3PCF), as well as power spectrum and bispectrum. We discuss the accuracy and self-consistency of the halo model description of gravitational clustering in the non-linear regime and constrain halo model parameters. We exploit the recently proposed multipole expansion of three point statistics that expresses rotation invariance in the most natural way. This not only offers technical advantages by reducing the integrals required for the halo model predictions, but amounts to a convenient way of compressing the information contained in the 3PCF. We find that, with an appropriate choice of the halo boundary and mass function cut-off, halo model predictions are in good agreement with the bispectrum measured in numerical simulations. However, the halo model predicts less than the observed configuration dependence of the 3PCF on ~ Mpc scales. This effect is mainly due to quadrupole moment deficit, possibly related to the assumption of spherical halo geometry. Our analysis shows that using its harmonic decomposition, the full configuration dependence of the 3PCF in the non-linear regime can be compressed into just a few numbers, the lowest multipoles. Moreover, these multipoles are closely related to the highest signal to noise eigenmodes of the 3PCF. Therefore this estimator may simplify future analyses aimed at constraining cosmological and halo model parameters from observational data.Comment: Minor corrections. Accepted for publication by Ap

Safety and efficacy of nateglinide/metformin combination therapy in the treatment of type 2 diabetes

The increasing prevalence of type 2 diabetes provides impetus for both development of new drugs to improve glycemic control and for reconsideration of treatment strategies with existing agents. Combination therapy with complementary drug classes that act on different aspects of glycemic control has been a particularly effective strategy. This work reviews the published literature reporting efficacy and safety/tolerability of nateglinide, a rapid-onset insulinotropic agent with a predominant effect to reduce postprandial glucose, when combined with metformin, a first-line agent that suppresses hepatic glucose production and thereby reduces fasting plasma glucose. The nateglinide/metformin combination has consistently been found to be both efficacious and well tolerated, whether given as initial combination therapy in drug-naïve patients or when added to metformin monotherapy. Maximum efficacy (Δ glycosylated hemoglobin [HbA1c]= −1.4% to −1.9%, sustained for up to 2 years of treatment) was seen in studies of drug-naïve patients in whom pharmacotherapy was initiated with the combination of nateglinide and metformin, and modest reductions in HbA1c (Δ = −0.5% to −1.2%, sustained for up to 24 weeks) were found when nateglinide was added to ongoing metformin monotherapy

NMR microscopy of tissue in organic and mixed solvents

We propose to use organic and mixed solvents for nuclear magnetic resonance microscopy of fixed tissue as a means for improving image information content. NMR properties of some standard solvents (methanol, acetone, DMSO) and solvents in use for tissue processing in pathology (xylenes, paraffin, ‘Clearify’) have been measured, reviewed, and analyzed. It was found that DMSO and paraffin are very useful solvents that provide images of better quality than those obtained in water (neutralized formalin buffer). This is illustrated on the formalin fixed mouse brain sections imaged at 16.4 teslas (700 MHz)

Specific modulation of airway epithelial tight junctions by apical application of an occludin peptide

Tight junctions are directly involved in regulating the passage of ions and macromolecules (gate functions) in epithelial and endothelial cells. The modulation of these gate functions to transiently regulate the paracellular permeability of large solutes and ions could increase the delivery of pharmacological agents or gene transfer vectors. To reduce the inflammatory responses caused by tight junction-regulating agents, alternative strategies directly targeting specific tight junction proteins could prove to be less toxic to airway epithelia. The apical delivery of peptides corresponding to the first extracellular loop of occludin to transiently modulate apical paracellular flux has been demonstrated in intestinal epithelia. We hypothesized that apical application of these occludin peptides could similarly modulate tight junction permeability in airway epithelia. Thus, we investigated the effects of apically applied occludin peptide on the paracellular permeability of molecular tracers and viral vectors in well differentiated human airway epithelial cells. The effects of occludin peptide on cellular toxicity, tight junction protein expression and localization, and membrane integrity were also assessed. Our data showed that apically applied occludin peptide significantly reduced transepithelial resistance in airway epithelia and altered tight junction permeability in a concentration-dependent manner. These alterations enhanced the paracellular flux of dextrans as well as gene transfer vectors. The occludin peptide redistributed occludin but did not alter the expression or distribution of ZO-1, claudin-1, or claudin-4. These data suggest that specific targeting of occludin could be a better-suited alternative strategy for tight junction modulation in airway epithelial cells compared with current agents that modulate tight junctions

Robust super-resolution depth imaging via a multi-feature fusion deep network

Three-dimensional imaging plays an important role in imaging applications where it is necessary to record depth. The number of applications that use depth imaging is increasing rapidly, and examples include self-driving autonomous vehicles and auto-focus assist on smartphone cameras. Light detection and ranging (LIDAR) via single-photon sensitive detector (SPAD) arrays is an emerging technology that enables the acquisition of depth images at high frame rates. However, the spatial resolution of this technology is typically low in comparison to the intensity images recorded by conventional cameras. To increase the native resolution of depth images from a SPAD camera, we develop a deep network built specifically to take advantage of the multiple features that can be extracted from a camera's histogram data. The network is designed for a SPAD camera operating in a dual-mode such that it captures alternate low resolution depth and high resolution intensity images at high frame rates, thus the system does not require any additional sensor to provide intensity images. The network then uses the intensity images and multiple features extracted from downsampled histograms to guide the upsampling of the depth. Our network provides significant image resolution enhancement and image denoising across a wide range of signal-to-noise ratios and photon levels. We apply the network to a range of 3D data, demonstrating denoising and a four-fold resolution enhancement of depth